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Japanese Journal of Ophthalmology

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01-05-2011 | Clinical Investigation

Vitreous inflammatory factors in macular edema with central retinal vein occlusion

Authors: Hidetaka Noma, Hideharu Funatsu, Seiyo Harino, Tatsuya Mimura, Shuichiro Eguchi, Sadao Hori

Published in: Japanese Journal of Ophthalmology | Issue 3/2011

Abstract

Purpose

To investigate the correlation of soluble intercellular adhesion molecule 1 (sICAM-1) and vascular endothelial growth factor (VEGF) with macular edema in patients with central retinal vein occlusion (CRVO).

Methods

Twenty-nine patients who had CRVO with macular edema and 16 patients with non-ischemic ocular diseases (control group) participated. Retinal ischemia was evaluated by measuring the area of capillary non-perfusion with fluorescein angiography and the public domain Scion Image program. Macular edema was examined by optical coherence tomography. Vitreous samples were obtained during pars plana vitrectomy. VEGF and sICAM-1 levels in vitreous fluid and plasma were determined by enzyme-linked immunosorbent assay.

Results

The median vitreous levels of VEGF and sICAM-1 were significantly higher in the CRVO patients than in the control group [366 vs. 15.6 pg/ml (P < 0.001) and 20.5 vs. 5.0 ng/ml (P < 0.001), respectively]. Vitreous levels of both VEGF and sICAM-1 were also significantly higher in the CRVO patients who had retinal ischemia than in those without ischemia (P < 0.001 and P = 0.011, respectively). Vitreous levels of VEGF and sICAM-1 were also significantly correlated with the severity of macular edema (P = 0.004 and P = 0.012, respectively).

Conclusions

VEGF and sICAM-1 may both increase vascular permeability in CRVO patients with macular edema, with sICAM-1 acting together with and/or via VEGF.

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Title: Vitreous inflammatory factors in macular edema with central retinal vein occlusion
Authors: Hidetaka Noma
Hideharu Funatsu
Seiyo Harino
Tatsuya Mimura
Shuichiro Eguchi
Sadao Hori
Publication date: 01-05-2011
Publisher: Springer Japan
Published in: Japanese Journal of Ophthalmology / Issue 3/2011
Print ISSN: 0021-5155
Electronic ISSN: 1613-2246
DOI: https://doi.org/10.1007/s10384-011-0016-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Vitreous inflammatory factors in macular edema with central retinal vein occlusion

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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