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01-05-2008 | Original Contribution

Insulin Therapy and Colorectal Adenoma Risk Among Patients with Type 2 Diabetes Mellitus: A Case-Control Study in Korea

Authors: Yong Woo Chung, M.D., Dong Soo Han, M.D., Kwang Hyuk Park, M.D., Chang Soo Eun, M.D., Kyo-Sang Yoo, M.D., Choong Kee Park, M.D.

Published in: Diseases of the Colon & Rectum | Issue 5/2008

Abstract

Purpose

Patients with Type 2 diabetes mellitus may be at increased colorectal adenoma and cancer risk. Moreover, chronic insulin therapy may increase the risk of colorectal cancer among patients with Type 2 diabetes mellitus. We investigated to determine whether insulin therapy might increase the risk of colorectal adenoma among clinically confirmed patients with Type 2 diabetes mellitus.

Methods

We conducted a retrospective study among patients with Type 2 diabetes mellitus who underwent total colonoscopy between January 2003 and July 2006 at Hallym University Sacred Heart Hospital. Among them (n = 325), patients with histologically confirmed colorectal adenomas (n = 100) and the same number of controls matched by age and sex were selected and analyzed.

Results

Adenoma cases showed significantly higher rate of chronic insulin therapy (more than 1 year) than controls (P = 0.018). In multivariate regression analysis, patients who received chronic insulin therapy had three times the risk of colorectal adenoma compared with patients who received no insulin (odds ratio, 3; 95 percent confidence interval, 1.1–8.9; P = 0.04).

Conclusions

Chronic insulin therapy was associated with increased colorectal adenoma risk among Type 2 diabetes mellitus patients. This result may provide a need for more intensive colorectal cancer screening program in patients with Type 2 diabetes mellitus, especially those who receive chronic insulin therapy.

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Title: Insulin Therapy and Colorectal Adenoma Risk Among Patients with Type 2 Diabetes Mellitus: A Case-Control Study in Korea
Authors: Yong Woo Chung, M.D.
Dong Soo Han, M.D.
Kwang Hyuk Park, M.D.
Chang Soo Eun, M.D.
Kyo-Sang Yoo, M.D.
Choong Kee Park, M.D.
Publication date: 01-05-2008
Publisher: Springer-Verlag
Published in: Diseases of the Colon & Rectum / Issue 5/2008
Print ISSN: 0012-3706
Electronic ISSN: 1530-0358
DOI: https://doi.org/10.1007/s10350-007-9184-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Insulin Therapy and Colorectal Adenoma Risk Among Patients with Type 2 Diabetes Mellitus: A Case-Control Study in Korea

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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