Skip to main content
Top
Published in: Diseases of the Colon & Rectum 12/2007

01-12-2007 | Current Status

Rectovaginal Fistula in Crohn’s Disease

Authors: S. M. Andreani, M.D., F.R.C.S.(Gen.), H. H. Dang, M.D., P. Grondona, M.D., A. Z. Khan, F.R.C.S.(Gen.), D. P. Edwards, F.R.C.S.(Gen.), E.B.S.Q.

Published in: Diseases of the Colon & Rectum | Issue 12/2007

Login to get access

Abstract

Purpose

Crohn’s disease is characterized by transmural bowel inflammation and a tendency to form fistulas with adjacent structures. Several different fistulas have been described: enterocutaneous, enteroenteric, enterovesical, enterovaginal, and perineal. Rectovaginal fistulas are difficult to treat despite multimodal therapy. This study was designed to review the current strategic options to best manage this condition.

Methods

We reviewed the English-language literature from 1966 to 2006, using PUBMED, targeting Crohn’s disease involving vagina using key words “rectovaginal fistula and CD,” “anovaginal fistula and CD,” “anovaginal fistula,” and “rectovaginal fistula.” We excluded the involvement of the vagina from a pouch after a proctectomy. A total of 776 articles were found; 206 articles were identified and judged as being relevant on the basis of title-related articles and links were reviewed. Fifty-three articles were selected after reading the abstract or full manuscript.

Results

The management of rectovaginal fistula, representing 9 percent of all fistulas, remains a challenge in the setting of Crohn’s disease. Medical treatments are not favorable with low rates of long-term symptomatic control and unacceptable high rates of recurrence. Several novel and new surgical techniques have been described, and rectal advancement flap, in selected patients, seems to have the most successful results.

Conclusions

The management of rectovaginal fistula of Crohn’s origin should involve both gastroenterologists and coloproctologists, with the best surgical results being achieved in patients receiving optimum medical therapy. More focused studies targeting these patients with the use of combined medical and surgical therapy are necessary.
Literature
1.
go back to reference Adams F. The genuine works of Hippocrates. Baltimore: Williams and Wilkins, 1939:308. Adams F. The genuine works of Hippocrates. Baltimore: Williams and Wilkins, 1939:308.
2.
go back to reference Gabriel WB. Results of an experimental and histological investigation of seventy-five cases of rectal fistulae. Proc R Soc Med 1921;14:156-61.PubMed Gabriel WB. Results of an experimental and histological investigation of seventy-five cases of rectal fistulae. Proc R Soc Med 1921;14:156-61.PubMed
3.
go back to reference Crohn BB, Ginzburg L, Oppenheimer GD. Regional ileitis: a pathological and clinical entity. JAMA 1932;99:1323-8. Crohn BB, Ginzburg L, Oppenheimer GD. Regional ileitis: a pathological and clinical entity. JAMA 1932;99:1323-8.
5.
go back to reference Schwartz DA, Loftus EV Jr, Tremaine WJ, et al. The natural history of fistulizing Crohn’s disease in Olmsted County, Minnesota. Gastroenterology 2002;122:875-80.PubMedCrossRef Schwartz DA, Loftus EV Jr, Tremaine WJ, et al. The natural history of fistulizing Crohn’s disease in Olmsted County, Minnesota. Gastroenterology 2002;122:875-80.PubMedCrossRef
6.
go back to reference Radcliffe AG, Ritchie JK, Hawley PR, Lennard-Jones JE, Northover JM. Anovaginal and rectovaginal fistulas in Crohn’s disease. Dis Colon Rectum 1988;31:94-9.PubMedCrossRef Radcliffe AG, Ritchie JK, Hawley PR, Lennard-Jones JE, Northover JM. Anovaginal and rectovaginal fistulas in Crohn’s disease. Dis Colon Rectum 1988;31:94-9.PubMedCrossRef
7.
go back to reference Sher ME, Bauer JJ, Gelernt I. Surgical repair of rectovaginal fistulas in patients with Crohn’s disease: transvaginal approach. Dis Colon Rectum 1991;34:641-8.PubMedCrossRef Sher ME, Bauer JJ, Gelernt I. Surgical repair of rectovaginal fistulas in patients with Crohn’s disease: transvaginal approach. Dis Colon Rectum 1991;34:641-8.PubMedCrossRef
8.
9.
go back to reference Heyen F, Winslet MC, Andrews H, Alexander-Williams J, Keighley MR. Vaginal fistulas in Crohn’s disease. Dis Colon Rectum 1989;32:379-83.PubMedCrossRef Heyen F, Winslet MC, Andrews H, Alexander-Williams J, Keighley MR. Vaginal fistulas in Crohn’s disease. Dis Colon Rectum 1989;32:379-83.PubMedCrossRef
10.
go back to reference Rankin GB, Watts HD, Melnyk CS, Kelley ML. National Cooperative Crohn’s Disease Study: extraintestinal manifestations and perianal complications. Gastroenterology 1979;77:914-20.PubMed Rankin GB, Watts HD, Melnyk CS, Kelley ML. National Cooperative Crohn’s Disease Study: extraintestinal manifestations and perianal complications. Gastroenterology 1979;77:914-20.PubMed
11.
go back to reference Hesterberg R, Schmidt WU, Muller F, Roher HD. Treatment of anovaginal fistulas with an anocutaneous flap in patients with Crohn’s disease. Int J Colorectal Dis 1993;8:51-4.PubMedCrossRef Hesterberg R, Schmidt WU, Muller F, Roher HD. Treatment of anovaginal fistulas with an anocutaneous flap in patients with Crohn’s disease. Int J Colorectal Dis 1993;8:51-4.PubMedCrossRef
12.
go back to reference Fry RD, Shemesh EI, Kodner IJ, Timmcke A. Techniques and results in the management of anal and perianal Crohn’s disease. Surg Gynecol Obstet 1989;168:42-8.PubMed Fry RD, Shemesh EI, Kodner IJ, Timmcke A. Techniques and results in the management of anal and perianal Crohn’s disease. Surg Gynecol Obstet 1989;168:42-8.PubMed
13.
go back to reference Van Patter WN, Bargen JA, Dockerty MB, et al. Regional enteritis. Gastroenterology 1954;26:347-450. Van Patter WN, Bargen JA, Dockerty MB, et al. Regional enteritis. Gastroenterology 1954;26:347-450.
14.
go back to reference Ritchie JK, Lennard-Jones JE. Crohn’s disease of the distal large bowel. Scand J Gastroenterol 1976;11:433-6.PubMed Ritchie JK, Lennard-Jones JE. Crohn’s disease of the distal large bowel. Scand J Gastroenterol 1976;11:433-6.PubMed
15.
go back to reference Morrison JG, Gathright JB, Ray JE, Ferrari BT, Hicks TC, Timmcke AE. Results of operation for rectovaginal fistula in Crohn’s disease. Dis Colon Rectum 1989;32:497-9.PubMedCrossRef Morrison JG, Gathright JB, Ray JE, Ferrari BT, Hicks TC, Timmcke AE. Results of operation for rectovaginal fistula in Crohn’s disease. Dis Colon Rectum 1989;32:497-9.PubMedCrossRef
16.
go back to reference Nicholls RJ, Dozois RR. Surgery of the colon and rectum. London: Churchill Livingstone, 1997:632-3. Nicholls RJ, Dozois RR. Surgery of the colon and rectum. London: Churchill Livingstone, 1997:632-3.
17.
go back to reference Abel ME, Chiu YS, Russell TR, Volpe PA. Autologous fibrin glue in the treatment of rectovaginal and complex fistulas. Dis Colon Rectum 1993;36:447-9.PubMedCrossRef Abel ME, Chiu YS, Russell TR, Volpe PA. Autologous fibrin glue in the treatment of rectovaginal and complex fistulas. Dis Colon Rectum 1993;36:447-9.PubMedCrossRef
18.
go back to reference Brandt LJ, Bernstein LH, Boley SJ, Frank MS. Metronidazole therapy for perirectal Crohn’s disease: a follow-up study. Gastroenterology 1982;83:383-7.PubMed Brandt LJ, Bernstein LH, Boley SJ, Frank MS. Metronidazole therapy for perirectal Crohn’s disease: a follow-up study. Gastroenterology 1982;83:383-7.PubMed
19.
go back to reference Bernstein LH, Frank MS, Brandt LJ, Boley SJ. Healing of perineal Crohn’s disease with metronidazole. Gastroenterology 1980;79:357-65.PubMed Bernstein LH, Frank MS, Brandt LJ, Boley SJ. Healing of perineal Crohn’s disease with metronidazole. Gastroenterology 1980;79:357-65.PubMed
20.
go back to reference Dejaco C, Harrer M, Waldhoer T, Miehsler W, Vogelsang H, Reinisch W. Antibiotics and azathioprine for the treatment of perianal fistulas in Crohn’s disease. Aliment Pharmacol Ther 2003;18:1113-20.PubMedCrossRef Dejaco C, Harrer M, Waldhoer T, Miehsler W, Vogelsang H, Reinisch W. Antibiotics and azathioprine for the treatment of perianal fistulas in Crohn’s disease. Aliment Pharmacol Ther 2003;18:1113-20.PubMedCrossRef
21.
go back to reference Turunen U, Farkkila M, Seppala K. Long-term treatment of perianal or fistulous Crohn’s disease with ciprofloxacin. Scan J Gastroenterol 1989;24:144. Turunen U, Farkkila M, Seppala K. Long-term treatment of perianal or fistulous Crohn’s disease with ciprofloxacin. Scan J Gastroenterol 1989;24:144.
22.
go back to reference Wolf JL. Ciprofloxacin may be useful in Crohn’s disease. Gastroenterology 1990;98:A212. Wolf JL. Ciprofloxacin may be useful in Crohn’s disease. Gastroenterology 1990;98:A212.
23.
go back to reference Solomon MJ, McLeod RS, O’Connor BI, Steinhart A, Greenberg G, Cohen Z. Combination ciprofloxacin and metronidazole in severe perianal Crohn’s disease. Can J Gastroenterol 1993;7:571-3. Solomon MJ, McLeod RS, O’Connor BI, Steinhart A, Greenberg G, Cohen Z. Combination ciprofloxacin and metronidazole in severe perianal Crohn’s disease. Can J Gastroenterol 1993;7:571-3.
24.
go back to reference Korelitz B, Present D. Favorable effect of 6-mercaptopurine on fistulae of Crohn’s Disease. Dig Dis Sci 1985;30:58-64.PubMedCrossRef Korelitz B, Present D. Favorable effect of 6-mercaptopurine on fistulae of Crohn’s Disease. Dig Dis Sci 1985;30:58-64.PubMedCrossRef
25.
go back to reference Present DH, Korelitz BI, Wisch N, Glass JL, Sachar DB, Pastermack BS. Treatment of Crohn’s disease with 6-mercaptopurine. A long-term randomized, double-blind study. N Engl J Med 1980:302:981-7.PubMedCrossRef Present DH, Korelitz BI, Wisch N, Glass JL, Sachar DB, Pastermack BS. Treatment of Crohn’s disease with 6-mercaptopurine. A long-term randomized, double-blind study. N Engl J Med 1980:302:981-7.PubMedCrossRef
26.
go back to reference Brynskov J, Freund L, Rasmussen SN, et al. A placebo-controlled double blind randomized trial of cyclosporine therapy in active chronic Crohn’s disease. N Engl J Med 1989;321:845-50.PubMedCrossRef Brynskov J, Freund L, Rasmussen SN, et al. A placebo-controlled double blind randomized trial of cyclosporine therapy in active chronic Crohn’s disease. N Engl J Med 1989;321:845-50.PubMedCrossRef
27.
go back to reference Present DH, Lichtiger S. Efficacy of cyclosporine in treatment of fistula of Crohn’s disease. Dig Dis Sci 1994;39:374-80.PubMedCrossRef Present DH, Lichtiger S. Efficacy of cyclosporine in treatment of fistula of Crohn’s disease. Dig Dis Sci 1994;39:374-80.PubMedCrossRef
28.
go back to reference Hanauer SB, Smith MB. Rapid closure of Crohn’s disease fistulas with continuous intravenous cyclosporine A. Am J Gatroenterol 1993;88:646-9. Hanauer SB, Smith MB. Rapid closure of Crohn’s disease fistulas with continuous intravenous cyclosporine A. Am J Gatroenterol 1993;88:646-9.
29.
go back to reference Amati L, Caradonna L, Jirillo E, Caccavo D. Immunological disorders in inflammatory bowel disease and immunotherapeutic implications. Ital J Gastroenterol Hepatol 1999;31:313-25.PubMed Amati L, Caradonna L, Jirillo E, Caccavo D. Immunological disorders in inflammatory bowel disease and immunotherapeutic implications. Ital J Gastroenterol Hepatol 1999;31:313-25.PubMed
30.
go back to reference Hanauer SB, Feagan BG, Lichtenstein GR, et al. ACCENT I Study Group. Maintenance of infliximab for Crohn’s disease: the ACCENT 1 randomised trial. Lancet 2002;359:1541-9.PubMedCrossRef Hanauer SB, Feagan BG, Lichtenstein GR, et al. ACCENT I Study Group. Maintenance of infliximab for Crohn’s disease: the ACCENT 1 randomised trial. Lancet 2002;359:1541-9.PubMedCrossRef
31.
go back to reference D’haens G, Van Deventer S, Van Hogezand R, et al. Endoscopic and histological healing with infliximab anti-tumor nerosis factor antibodies in Crohn’s disease: a European multicenter trial. Gastroenterology 1999;116:1029-34.PubMedCrossRef D’haens G, Van Deventer S, Van Hogezand R, et al. Endoscopic and histological healing with infliximab anti-tumor nerosis factor antibodies in Crohn’s disease: a European multicenter trial. Gastroenterology 1999;116:1029-34.PubMedCrossRef
32.
go back to reference Topstad D, Panaccione R, Heine JA, Johnson DR, MacLean AR, Buie WD. Combined seton placement, infliximab infusion and maintenance immunosuppressives improve healing rate in fistulizing anorectal Crohn’s Disease. A single-center experience. Dis Colon Rectum 2003;46:577-83.PubMedCrossRef Topstad D, Panaccione R, Heine JA, Johnson DR, MacLean AR, Buie WD. Combined seton placement, infliximab infusion and maintenance immunosuppressives improve healing rate in fistulizing anorectal Crohn’s Disease. A single-center experience. Dis Colon Rectum 2003;46:577-83.PubMedCrossRef
33.
go back to reference Present DH, Rutgeerts P, Targan S, et al. Infliximab for the treatment of fistulas in patients with Crohn’s disease. N Engl J Med 1999;340:1398-405.PubMedCrossRef Present DH, Rutgeerts P, Targan S, et al. Infliximab for the treatment of fistulas in patients with Crohn’s disease. N Engl J Med 1999;340:1398-405.PubMedCrossRef
34.
go back to reference Parsi M, Lashner B, Achkar JP, Connor JT, Brzezinski A. Type of fistula determines response to infliximab in patients with fistulous Crohn’s Disease. Am J Gastroenterol 2004;99:445-9.PubMedCrossRef Parsi M, Lashner B, Achkar JP, Connor JT, Brzezinski A. Type of fistula determines response to infliximab in patients with fistulous Crohn’s Disease. Am J Gastroenterol 2004;99:445-9.PubMedCrossRef
35.
go back to reference Van Bodegraven AA, Sloots CE, Felt-Bersma RJ, Meuwissen SG. Endosonographic evidence of persistence of Crohn’s disease associated fistulas after inflixmab treatment, irrespective of clinical response. Dis Colon Rectum 2002;45:39-45.PubMedCrossRef Van Bodegraven AA, Sloots CE, Felt-Bersma RJ, Meuwissen SG. Endosonographic evidence of persistence of Crohn’s disease associated fistulas after inflixmab treatment, irrespective of clinical response. Dis Colon Rectum 2002;45:39-45.PubMedCrossRef
36.
go back to reference Ricart E, Panaccione R, Loftus EV, Tremaine WJ, Sandborn WJ. Infliximab for Crohn’s disease in clinical practice at the Mayo Clinic: the first 100 patients. Am J Gastroenterol 2001;96:722-9.PubMedCrossRef Ricart E, Panaccione R, Loftus EV, Tremaine WJ, Sandborn WJ. Infliximab for Crohn’s disease in clinical practice at the Mayo Clinic: the first 100 patients. Am J Gastroenterol 2001;96:722-9.PubMedCrossRef
37.
go back to reference Farrell RJ, Shah SA, Lodhavia PJ, et al. Clinical experience with infliximab therapy in 100 patients with Crohn’s Disease. Am J Gastroenterol 2000;95:3490-7.PubMedCrossRef Farrell RJ, Shah SA, Lodhavia PJ, et al. Clinical experience with infliximab therapy in 100 patients with Crohn’s Disease. Am J Gastroenterol 2000;95:3490-7.PubMedCrossRef
38.
go back to reference Sands BE, Blank MA, Patel K, van Deventer SJ. Long-term treatment of rectovaginal fistulas in Crohn’s Disease: Response to infliximab in the ACCENT II study. Clin Gastroenterol Hepatol 2004;2:912-20.PubMedCrossRef Sands BE, Blank MA, Patel K, van Deventer SJ. Long-term treatment of rectovaginal fistulas in Crohn’s Disease: Response to infliximab in the ACCENT II study. Clin Gastroenterol Hepatol 2004;2:912-20.PubMedCrossRef
39.
go back to reference Ochsenkuhn T, Goke B, Sackmann M. Combining infliximab with 6-mercaptopurine/azathioprine for fistula therapy in Crohn’s disease. Am J Gastroenterol 2002;97:2022-5.PubMed Ochsenkuhn T, Goke B, Sackmann M. Combining infliximab with 6-mercaptopurine/azathioprine for fistula therapy in Crohn’s disease. Am J Gastroenterol 2002;97:2022-5.PubMed
40.
go back to reference Rasul I, Wilson SR, MacRae H, Irwin S, Greenberg GR. Clinical and radiologial responses after infliximab treatment for perianal fistulizing Crohn’s disease. Am J Gastroenterol 2004;99:82-8.PubMedCrossRef Rasul I, Wilson SR, MacRae H, Irwin S, Greenberg GR. Clinical and radiologial responses after infliximab treatment for perianal fistulizing Crohn’s disease. Am J Gastroenterol 2004;99:82-8.PubMedCrossRef
41.
go back to reference Ardizzone S, Maconi G, Colombo E, Manzionna G, Bollani S, Bianchi Porro G. Perianal fistula following infliximab treatment:clinical and endosonographic outcome. Inflamm Bowel Dis 2004;10:91-6.PubMedCrossRef Ardizzone S, Maconi G, Colombo E, Manzionna G, Bollani S, Bianchi Porro G. Perianal fistula following infliximab treatment:clinical and endosonographic outcome. Inflamm Bowel Dis 2004;10:91-6.PubMedCrossRef
42.
go back to reference Bell SJ, Halligan S, Windsor AC, Williams AB, Wiesel P, Kamm MA. Response of fistulating Crohn’s disease to infliximab treatment assessed by MRI. Aliment Pharmacol Ther 2003;17:387-93.PubMedCrossRef Bell SJ, Halligan S, Windsor AC, Williams AB, Wiesel P, Kamm MA. Response of fistulating Crohn’s disease to infliximab treatment assessed by MRI. Aliment Pharmacol Ther 2003;17:387-93.PubMedCrossRef
43.
go back to reference Scott NA, Nair A, Hughes LE. Anovaginal and rectovaginal fistula in patients with Crohn’s disease. Br J Surg 1992;79:1379-80.PubMedCrossRef Scott NA, Nair A, Hughes LE. Anovaginal and rectovaginal fistula in patients with Crohn’s disease. Br J Surg 1992;79:1379-80.PubMedCrossRef
44.
go back to reference Levy C, Tremaine WJ. Management of internal fistulas in Crohn’s disease. Inflamm Bowel Dis 2002;8:106-11.PubMedCrossRef Levy C, Tremaine WJ. Management of internal fistulas in Crohn’s disease. Inflamm Bowel Dis 2002;8:106-11.PubMedCrossRef
45.
46.
go back to reference Thornton M, Solomon MJ. Long-term indwelling seton for complex anal fistulas in Crohn’s disease. Dis Colon Rectum 2005;48:459-63.PubMedCrossRef Thornton M, Solomon MJ. Long-term indwelling seton for complex anal fistulas in Crohn’s disease. Dis Colon Rectum 2005;48:459-63.PubMedCrossRef
47.
go back to reference Solomon MJ, McLeod RS, Cohen EK, Cohen Z. Anal wall thickness under normal and inflammatory conditions of the anorectum as determined by endoluminal ultrasonography. Am J Gastroenterol 1995;90:574-8.PubMed Solomon MJ, McLeod RS, Cohen EK, Cohen Z. Anal wall thickness under normal and inflammatory conditions of the anorectum as determined by endoluminal ultrasonography. Am J Gastroenterol 1995;90:574-8.PubMed
48.
go back to reference Noble GH. A new operation for complete laceration of the perineum designed for the purpose of eliminating danger of infection from the rectum. Trans Am Gynecol Soc 1902;27:357-63. Noble GH. A new operation for complete laceration of the perineum designed for the purpose of eliminating danger of infection from the rectum. Trans Am Gynecol Soc 1902;27:357-63.
49.
50.
go back to reference Farkas AM, Gingold BS. Repair of rectovaginal fistula in Crohn’s disease by rectal mucosal advancement flap. Mt Sinai J Med 1983;50:420-3.PubMed Farkas AM, Gingold BS. Repair of rectovaginal fistula in Crohn’s disease by rectal mucosal advancement flap. Mt Sinai J Med 1983;50:420-3.PubMed
51.
go back to reference Penninckx F, d’Hoore A, Filez L. Advancement flap plasty for the closure of anal and recto-vaginal fistulas in Crohn’s disease. Acta Gastroenterol Belg 2001;64:223-6.PubMed Penninckx F, d’Hoore A, Filez L. Advancement flap plasty for the closure of anal and recto-vaginal fistulas in Crohn’s disease. Acta Gastroenterol Belg 2001;64:223-6.PubMed
52.
go back to reference Greenwald JC, Hoexter B. Repair of rectovaginal fistulas. Surg Gynecol Obstet 1978;146:443-5.PubMed Greenwald JC, Hoexter B. Repair of rectovaginal fistulas. Surg Gynecol Obstet 1978;146:443-5.PubMed
53.
go back to reference Cohen JL, Stricker JW, Schoetz DJ, Coller JA, Veidenheimer MC. Rectovaginal fistula in Crohn’s disease. Dis Colon Rectum 1989;32:825-8.PubMedCrossRef Cohen JL, Stricker JW, Schoetz DJ, Coller JA, Veidenheimer MC. Rectovaginal fistula in Crohn’s disease. Dis Colon Rectum 1989;32:825-8.PubMedCrossRef
54.
go back to reference Crim RW, Fazio VW, Laveri IC. Rectal advancement flap repair in Crohn’s disease. Factors predictive of failure. Dis Colon Rectum 1990;33:P3. Crim RW, Fazio VW, Laveri IC. Rectal advancement flap repair in Crohn’s disease. Factors predictive of failure. Dis Colon Rectum 1990;33:P3.
55.
go back to reference Makowiec F, Jehle EC, Becker HD, Starlinger M. Clinical course after transanal advancement flap repair of perianal fistula in patients with Crohn’s disease. Br J Surg 1999;82:603-6.CrossRef Makowiec F, Jehle EC, Becker HD, Starlinger M. Clinical course after transanal advancement flap repair of perianal fistula in patients with Crohn’s disease. Br J Surg 1999;82:603-6.CrossRef
56.
go back to reference Hull TL, Fazio VW. Surgical approaches to low anovaginal fistula in Crohn’s disease. Am J Surg 1997;173:95-8.PubMedCrossRef Hull TL, Fazio VW. Surgical approaches to low anovaginal fistula in Crohn’s disease. Am J Surg 1997;173:95-8.PubMedCrossRef
57.
go back to reference Kodner IJ, Mazor A, Shemesh EI, Fry RD, Fleshman JW, Bimbaum EH. Endorectal advancement flap repair of rectovaginal and other complicated anorectal fistulas. Surgery 1993;114:682-90.PubMed Kodner IJ, Mazor A, Shemesh EI, Fry RD, Fleshman JW, Bimbaum EH. Endorectal advancement flap repair of rectovaginal and other complicated anorectal fistulas. Surgery 1993;114:682-90.PubMed
58.
go back to reference Berman IR. Sleeve advancement anorectoplasty for complicated anorectal/vaginal fistula. Dis Colon Rectum 1991;34:1032-7.PubMedCrossRef Berman IR. Sleeve advancement anorectoplasty for complicated anorectal/vaginal fistula. Dis Colon Rectum 1991;34:1032-7.PubMedCrossRef
59.
go back to reference Marchesa P, Hull TL, Fazio VW. Advancement sleeve flaps for treatment of severe perianal Crohn’s disease. Br J Surg 1998;85:1695-8.PubMedCrossRef Marchesa P, Hull TL, Fazio VW. Advancement sleeve flaps for treatment of severe perianal Crohn’s disease. Br J Surg 1998;85:1695-8.PubMedCrossRef
60.
go back to reference Simmang CL, Lacey SW, Huber PJ. Rectal sleeve advancement: repair of rectovaginal fistula associated with anorectal stricture in Crohn’s disease. Dis Colon Rectum 1998;41:787-9.PubMedCrossRef Simmang CL, Lacey SW, Huber PJ. Rectal sleeve advancement: repair of rectovaginal fistula associated with anorectal stricture in Crohn’s disease. Dis Colon Rectum 1998;41:787-9.PubMedCrossRef
61.
go back to reference Joo JS, Weiss EG, Nogueras JJ, Wexner SD. Endorectal advancement flap in perianal Crohn’s disease. Am Surg 1998;64:147-50.PubMed Joo JS, Weiss EG, Nogueras JJ, Wexner SD. Endorectal advancement flap in perianal Crohn’s disease. Am Surg 1998;64:147-50.PubMed
62.
go back to reference MacRae HM, McLeod RS, Cohen Z, Stern H, Reznick R. Treatment of rectovaginal fistulas that has failed previous repair attempts. Dis Colon Rectum 1995;38:921-5.PubMedCrossRef MacRae HM, McLeod RS, Cohen Z, Stern H, Reznick R. Treatment of rectovaginal fistulas that has failed previous repair attempts. Dis Colon Rectum 1995;38:921-5.PubMedCrossRef
63.
go back to reference O’Leary DP, Milroy CE, Durdey P. Definitive repair of anovaginal fistula in Crohn’s disease. Ann R Coll Surg Engl 1998;80:250-2.PubMed O’Leary DP, Milroy CE, Durdey P. Definitive repair of anovaginal fistula in Crohn’s disease. Ann R Coll Surg Engl 1998;80:250-2.PubMed
64.
go back to reference Jones IT, Fazio VW, Jagelman DG. The use of transanal rectal advancement flaps in the management of fistulas involving the anorectum. Dis Colon Rectum 1987;30:919-23.PubMedCrossRef Jones IT, Fazio VW, Jagelman DG. The use of transanal rectal advancement flaps in the management of fistulas involving the anorectum. Dis Colon Rectum 1987;30:919-23.PubMedCrossRef
65.
go back to reference Grant DR, Cohen Z, McLeod R. Loop ileostomy for anorectal Crohn’s disease. Can J Surg 1986;29:32-5.PubMed Grant DR, Cohen Z, McLeod R. Loop ileostomy for anorectal Crohn’s disease. Can J Surg 1986;29:32-5.PubMed
Metadata
Title
Rectovaginal Fistula in Crohn’s Disease
Authors
S. M. Andreani, M.D., F.R.C.S.(Gen.)
H. H. Dang, M.D.
P. Grondona, M.D.
A. Z. Khan, F.R.C.S.(Gen.)
D. P. Edwards, F.R.C.S.(Gen.), E.B.S.Q.
Publication date
01-12-2007
Publisher
Springer-Verlag
Published in
Diseases of the Colon & Rectum / Issue 12/2007
Print ISSN: 0012-3706
Electronic ISSN: 1530-0358
DOI
https://doi.org/10.1007/s10350-007-9057-7

Other articles of this Issue 12/2007

Diseases of the Colon & Rectum 12/2007 Go to the issue