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Diseases of the Colon & Rectum
Published in: Diseases of the Colon & Rectum 11/2005

01-11-2005 | Original Contribution

Subcutaneous Gentamycin Implant to Reduce Wound Infections After Loop-Ileostomy Closure: A Randomized, Double-Blind, Placebo-Controlled Trial

Authors: O. Haase, M.D., W. Raue, M.D., B. Böhm, Ph.D., H. Neuss, M.D., M. Scharfenberg, M.D., W. Schwenk, Ph.D.

Published in: Diseases of the Colon & Rectum | Issue 11/2005

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BACKGROUND

After loop-ileostomy closure subcutaneous wound infection is the most frequent postoperative complication. Implantation of local antibiotics has been shown to reduce the incidence of wound infection after different surgical procedures, therefore, a subcutaneous application of a gentamycin implant may also decrease infection rate after ileostomy-closure.

METHODS

We conducted a randomized, double-blind, placebo-controlled trial to evaluate the effectiveness of a subcutaneous gentamycin–collagen implant to reduce wound infection after loop-ileostomy closure. Patients had the same perioperative treatment and standardized anastomotic and closure technique. A collagen sponge with gentamycin was used in the treatment group and an identical collagen implant without antibiotics was used in the placebo group.

RESULTS

Eighty patients (40 per group) were included. There was no difference between the groups with respect to demographics or in the postoperative course. The total wound infection rate was 10 percent with no difference between the gentamycin (n = 4) and the collagen group (n = 4) (P = 1.0).

CONCLUSION

Subcutaneous implantation of a gentamycin sponge yields no clinically relevant reduction of the wound infection rate after loop-ileostomy closure so that routine use is not recommended in this procedure.
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Metadata
Title
Subcutaneous Gentamycin Implant to Reduce Wound Infections After Loop-Ileostomy Closure: A Randomized, Double-Blind, Placebo-Controlled Trial
Authors
O. Haase, M.D.
W. Raue, M.D.
B. Böhm, Ph.D.
H. Neuss, M.D.
M. Scharfenberg, M.D.
W. Schwenk, Ph.D.
Publication date
01-11-2005
Publisher
Springer-Verlag
Published in
Diseases of the Colon & Rectum / Issue 11/2005
Print ISSN: 0012-3706
Electronic ISSN: 1530-0358
DOI
https://doi.org/10.1007/s10350-005-0164-z

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