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01-10-2005 | Original Contribution

CD10 Expression in Colorectal Carcinoma Correlates With Liver Metastasis

Authors: Yoshiya Fujimoto, M.D., Yukihiro Nakanishi, M.D., Shigeki Sekine, M.D., Kimio Yoshimura, M.D., Takayuki Akasu, M.D., Yoshihiro Moriya, M.D., Tadakazu Shimoda, M.D.

Published in: Diseases of the Colon & Rectum | Issue 10/2005

PURPOSE

If it were possible to identify the features of primary colorectal carcinoma that were associated with liver metastasis, these features could be used as predictors of liver metastasis.

METHODS

From January 1995 to December 1997, 648 consecutive cases of colorectal carcinoma were recorded at the Department of Surgery, National Cancer Center Hospital, Tokyo, Japan. We evaluated clinicopathologic and immunohistochemical factors (age, gender, tumor location, gross type, size, histologic type, dedifferentiation of invasive front, depth of invasion, lymphatic invasion, venous invasion, lymph-node metastasis, and expression of CD10, MUC2, and human gastric mucin) in 505 of these patients who had undergone resection of T2/T3/T4 colorectal carcinomas to clarify the correlation between these factors and liver metastasis.

RESULTS

Liver metastases, including unresectable, were detected in 122 patients (24 percent), all of whom had been followed for at least five years. Univariate analysis revealed that liver metastasis was significantly associated with tumor size, histologic type, dedifferentiation of invasive front, depth of invasion, lymphatic invasion, venous invasion, lymph-node metastasis, and CD10 expression. Multivariate analysis revealed that invasion deeper than the subserosa, venous invasion, lymph-node metastasis, and CD10 expression were significantly associated with liver metastases.

CONCLUSIONS

CD10 expression in colorectal carcinoma is a good predictor of liver metastasis.

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Title: CD10 Expression in Colorectal Carcinoma Correlates With Liver Metastasis
Authors: Yoshiya Fujimoto, M.D.
Yukihiro Nakanishi, M.D.
Shigeki Sekine, M.D.
Kimio Yoshimura, M.D.
Takayuki Akasu, M.D.
Yoshihiro Moriya, M.D.
Tadakazu Shimoda, M.D.
Publication date: 01-10-2005
Publisher: Springer-Verlag
Published in: Diseases of the Colon & Rectum / Issue 10/2005
Print ISSN: 0012-3706
Electronic ISSN: 1530-0358
DOI: https://doi.org/10.1007/s10350-005-0141-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

CD10 Expression in Colorectal Carcinoma Correlates With Liver Metastasis

PURPOSE

METHODS

RESULTS

CONCLUSIONS

Keynote webinar | Spotlight on medication adherence

Springer Medicine

PURPOSE

METHODS

RESULTS

CONCLUSIONS

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