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01-08-2005 | Original Contribution

Mechanical Bowel Preparation or Not? Outcome of a Multicenter, Randomized Trial in Elective Open Colon Surgery

Authors: Patrick Fa-Si-Oen, M.D., Rudi Roumen, M.D., Ph.D., John Buitenweg, M.D., Cornelis van de Velde, M.D., Ph.D., Dick van Geldere, M.D., Ph.D., Hein Putter, Ph.D., Charles Verwaest, M.D., Ph.D., Loes Verhoef, M.D., Ph.D., Jan-Willem de Waard, M.D., Ph.D., Dingeman Swank, M.D., Ph.D., Andre D’Hoore, M.D., Fred Croiset van Uchelen, M.D., Ph.D.

Published in: Diseases of the Colon & Rectum | Issue 8/2005

PURPOSE

Mechanical bowel preparation is common practice in elective colon surgery. In recent literature the value of this procedure is under discussion. To verify the value of mechanical bowel preparation in elective open colon surgery, a randomized clinical trial was conducted.

METHODS

During a prospective, multicenter, randomized study, 250 patients undergoing elective open colon surgery were randomized between receiving mechanical bowel preparation with polyethylene glycol (PEG group, 125 patients) and having a normal meal preoperatively (normal meal preoperatively group, 125 patients). Outcome parameters were wound infection with bacterial results of intraoperative swabs and anastomotic leak.

RESULTS

In the polyethylene glycol group there were a total of nine wound infections (7.2 percent) and seven anastomotic leaks (5.6 percent) compared with seven wound infections (5.6 percent) (P = 0.61) and six anastomotic leaks (4.8 percent) (P = 0.78) in the normal meal preoperatively group. Bacterial results showed 52 percent sterile subcutis swabs in the PEG group and 63 percent sterile subcutis swabs in the normal meal preoperatively group (P = 0.11).

CONCLUSION

In the pres-ent study we could not detect a difference in outcome parameters between patients receiving mechanical bowel preparation in elective open colon surgery and patients without preoperative treatment of the bowel. The present study, although underpowered, did not show a difference in the primary outcome of bacterial wound cultures between patients receiving preoperative mechanical bowel preparation and patients receiving no preoperative bowel treatment. We conclude that there may be no need to continue the use of mechanical bowel preparation in elective open colon surgery.

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Title: Mechanical Bowel Preparation or Not? Outcome of a Multicenter, Randomized Trial in Elective Open Colon Surgery
Authors: Patrick Fa-Si-Oen, M.D.
Rudi Roumen, M.D., Ph.D.
John Buitenweg, M.D.
Cornelis van de Velde, M.D., Ph.D.
Dick van Geldere, M.D., Ph.D.
Hein Putter, Ph.D.
Charles Verwaest, M.D., Ph.D.
Loes Verhoef, M.D., Ph.D.
Jan-Willem de Waard, M.D., Ph.D.
Dingeman Swank, M.D., Ph.D.
Andre D’Hoore, M.D.
Fred Croiset van Uchelen, M.D., Ph.D.
Publication date: 01-08-2005
Publisher: Springer-Verlag
Published in: Diseases of the Colon & Rectum / Issue 8/2005
Print ISSN: 0012-3706
Electronic ISSN: 1530-0358
DOI: https://doi.org/10.1007/s10350-005-0068-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Mechanical Bowel Preparation or Not? Outcome of a Multicenter, Randomized Trial in Elective Open Colon Surgery

PURPOSE

METHODS

RESULTS

CONCLUSION

Keynote webinar | Spotlight on medication adherence

Springer Medicine

PURPOSE

METHODS

RESULTS

CONCLUSION

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