Top

Magnetic Resonance Materials in Physics, Biology and Medicine

Published in:

01-06-2016 | Research Article

7 Tesla quantitative hip MRI: a comparison between TESS and CPMG for T2 mapping

Authors: Oliver Kraff, Andrea Lazik-Palm, Rahel Heule, Jens M. Theysohn, Oliver Bieri, Harald H. Quick

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 3/2016

Abstract

Objectives

We aimed to evaluate the feasibility of triple-echo steady state (TESS) T2 mapping as an alternative to conventional multi-echo-spin-echo (CPMG) T2 mapping for the quantitative assessment of hip joint cartilage at 7 T.

Materials and methods

A total of eight healthy volunteers and three patients were included. Reproducibility of both techniques was evaluated in five volunteers in five scans each. T2 relaxation times were measured by manually drawing regions of interest in multiple regions of the hip joint. Data from both methods were compared using Pearson correlation coefficient, intra-class correlation coefficient, and coefficient of repeatability. The overall image quality and presence of artifacts was assessed.

Results

Cartilage transplant and surrounding fluid were well depicted by both methods. Compared to CPMG, TESS provided systematically reduced T2 values (43.3 ± 7.3 vs. 19.2 ± 5.5 ms for acetabular cartilage, and 41.4 ± 5.6 vs. 21.7 ± 5.2 ms for femoral cartilage), in line with previously reported values. No correlation between both methods was found. TESS yielded a slightly better reproducibility than CPMG, while CPMG showed pronounced sensitivity to B1 inhomogeneities.

Conclusion

TESS seems to be an attractive alternative to CPMG for improvements in quantitative hip joint imaging at 7 T, allowing shortening of the total acquisition time paired with insensitivity to B1, while rendering comparable image quality with good repeatability.

Krug R, Stehling C, Kelley DA, Majumdar S, Link TM (2009) Imaging of the musculoskeletal system in vivo using ultra-high field magnetic resonance at 7 T. Invest Radiol 44(9):613–618CrossRefPubMed

Welsch GH, Apprich S, Zbyn S, Mamisch TC, Mlynarik V, Scheffler K, Bieri O, Trattnig S (2011) Biochemical (T2, T2* and magnetisation transfer ratio) MRI of knee cartilage: feasibility at ultra-high field (7T) compared with high field (3T) strength. Eur Radiol 21(6):1136–1143CrossRefPubMed

Ellermann J, Goerke U, Morgan P, Ugurbil K, Tian J, Schmitter S, Vaughan T, Van De Moortele PF (2012) Simultaneous bilateral hip joint imaging at 7 Tesla using fast transmit B(1) shimming methods and multichannel transmission—a feasibility study. NMR Biomed 25(10):1202–1208CrossRefPubMedPubMedCentral

Chang G, Deniz CM, Honig S, Egol K, Regatte RR, Zhu Y, Sodickson DK, Brown R (2014) MRI of the hip at 7T: feasibility of bone microarchitecture, high-resolution cartilage, and clinical imaging. J Magn Reson Imaging 39(6):1384–1393CrossRefPubMedPubMedCentral

Theysohn JM, Kraff O, Orzada S, Theysohn N, Classen T, Landgraeber S, Ladd ME, Lauenstein TC (2013) Bilateral hip imaging at 7 Tesla using a multi-channel transmit technology: initial results presenting anatomical detail in healthy volunteers and pathological changes in patients with avascular necrosis of the femoral head. Skeletal Radiol 42(11):1555–1563CrossRefPubMed

Kijowski R (2010) Clinical cartilage imaging of the knee and hip joints. AJR Am J Roentgenol 195(3):618–628CrossRefPubMed

Theysohn JM, Kraff O, Theysohn N, Orzada S, Landgraeber S, Ladd ME, Lauenstein TC (2014) Hip imaging of avascular necrosis at 7 Tesla compared with 3 Tesla. Skeletal Radiol 43(5):623–632CrossRefPubMed

Lazik A, Theysohn JM, Geis C, Johst S, Ladd ME, Quick HH, Kraff O (2015) 7 Tesla quantitative hip MRI: T1, T2 and T2* mapping of hip cartilage in healthy volunteers. Eur Radiol 26(5):1245–1253. doi:10.1007/s00330-015-3964-0 CrossRefPubMed

Meiboom S, Gill D (1958) Modified spin-echo method for measuring nuclear relaxation times. Rev Sci Instrum 29(8):688–691CrossRef

10.

Lebel RM, Wilman AH (2010) Transverse Relaxometry with Stimulated Echo Compensation. Magn Reson Med 64(4):1005–1014CrossRefPubMed

11.

Liney GP, Knowles AJ, Manton DJ, Turnbull LW, Blackband SJ, Horsman A (1996) Comparison of conventional single echo and multi-echo sequences with a fast spin echo sequence for quantitative T2 mapping: application to the prostate. J Magn Reson Imaging 6(4):603–607CrossRefPubMed

12.

Heule R, Ganter C, Bieri O (2014) Triple echo steady-state (TESS) relaxometry. Magn Reson Med 71(1):230–237CrossRefPubMed

13.

Heule R, Bar P, Mirkes C, Scheffler K, Trattnig S, Bieri O (2014) Triple-echo steady-state T2 relaxometry of the human brain at high to ultra-high fields. NMR Biomed 27(9):1037–1045CrossRefPubMed

14.

Riegler G, Drlicek G, Kronnerwetter C, Heule R, Bieri O, Hager B, Bär P (2015) Trattnig, Siegfried Triple-echo steady-state T2 mapping and high resolution axonal bundle assessment of the median nerve in healthy volunteers and patients with carpal tunnel syndrome at 7 Tesla. Proceedings 23rd Scientific Meeting. International Society for Magnetic Resonance in Medicine, Toronto, p 4226

15.

Juras V, Bohndorf K, Heule R, Kronnerwetter C, Szomolanyi P, Hager B, Bieri O, Zbyn S, Trattnig S (2015) A comparison of multi-echo spin-echo and triple-echo steady-state T2 mapping for in vivo evaluation of articular cartilage. Eur Radiol. doi:10.1007/s00330-015-3979-6

16.

Santini F, Patil S, Scheffler K (2011) IceLuva: a scripting framework for mr image reconstruction based on free software. Concepts Magn Reson Part B Magn Reson Eng 39B(1):1–10CrossRef

17.

Lazik A, Kraff O, Koersmeier K, Johst S, Geis C, Quick HH, Theysohn JM (2015) A Comprehensive 7 Tesla Hip Cartilage Protocol Including Morphological and Quantitative MRI Techniques and Its Application in Patients after Acetabular Autologous Chondrocyte Transplantation. In: Proceedings Scientific Assembly and Annual Meeting, Radiological Society of North America Chicago, IL, pp SSC07-06

18.

Bland JM, Altman DG (1986) Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1(8476):307–310CrossRefPubMed

19.

Hagiwara S, Nakamura J, Watanabe A, Kishida S, Ohtori S, Omae T, Miyamoto S, Orita S, Takahashi K (2015) Corticosteroids and low bone mineral density affect hip cartilage in systemic lupus erythematosus patients: quantitative T2 mapping. J Magn Reson Imaging 42(6):1524–1531. doi:10.1002/jmri.24953 CrossRefPubMed

20.

Kurkijarvi JE, Nissi MJ, Kiviranta I, Jurvelin JS, Nieminen MT (2004) Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and T2 characteristics of human knee articular cartilage: topographical variation and relationships to mechanical properties. Magn Reson Med 52(1):41–46CrossRefPubMed

21.

Hannila I, Lammentausta E, Tervonen O, Nieminen MT (2015) The repeatability of T2 relaxation time measurement of human knee articular cartilage. Magn Reson Mater Phy 28(6):547–553CrossRef

22.

Voogt IJ, Klomp DWJ, Hoogduin H, Luttje MP, Luijten PR, van den Berg CAT, Raaijmakers AJE (2015) Combined 8-channel transceiver fractionated dipole antenna array with a 16-channel loop coil receive array for body imaging at 7 Tesla. Proceedings 23rd Scientific Meeting. International Society for Magnetic Resonance in Medicine, Toronto, p 631

23.

Lattanzi R, Petchprapa C, Glaser C, Dunham K, Mikheev AV, Krigel A, Mamisch TC, Kim YJ, Rusinek H, Recht M (2012) A new method to analyze dGEMRIC measurements in femoroacetabular impingement: preliminary validation against arthroscopic findings. Osteoarthr Cartil 20(10):1127–1133CrossRefPubMed

24.

Trattnig S, Ohel K, Mlynarik V, Juras V, Zbyn S, Korner A (2015) Morphological and compositional monitoring of a new cell-free cartilage repair hydrogel technology - GelrinC by MR using semi-quantitative MOCART scoring and quantitative T2 index and new zonal T2 index calculation. Osteoarthr Cartil 23(12):2224–2232CrossRefPubMed

25.

Neumann D, Blaimer M, Jakob PM, Breuer FA (2014) Simple recipe for accurate T(2) quantification with multi spin-echo acquisitions. Magn Reson Mater Phy 27(6):567–577CrossRef

Title: 7 Tesla quantitative hip MRI: a comparison between TESS and CPMG for T2 mapping
Authors: Oliver Kraff
Andrea Lazik-Palm
Rahel Heule
Jens M. Theysohn
Oliver Bieri
Harald H. Quick
Publication date: 01-06-2016
Publisher: Springer Berlin Heidelberg
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 3/2016
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-016-0557-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

7 Tesla quantitative hip MRI: a comparison between TESS and CPMG for T2 mapping

Abstract

Objectives

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 3/2016

A comparison of phase imaging and quantitative susceptibility mapping in the imaging of multiple sclerosis lesions at ultrahigh field

Technical feasibility of integrating 7 T anatomical MRI in image-guided radiotherapy of glioblastoma: a preparatory study

Subjective perception of safety in healthy individuals working with 7 T MRI scanners: a retrospective multicenter survey

In vivo functional connectome of human brainstem nuclei of the ascending arousal, autonomic, and motor systems by high spatial resolution 7-Tesla fMRI

Radiofrequency pulse design with numerical optimization in the Fourier domain

Robust imaging of hippocampal inner structure at 7T: in vivo acquisition protocol and methodological choices