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Published in: Magnetic Resonance Materials in Physics, Biology and Medicine 5/2016

01-10-2016 | Research Article

Scan time minimization in hepatic diffusion-weighted imaging: evaluation of the simultaneous multislice acceleration technique with different acceleration factors and gradient preparation schemes

Authors: Jana Taron, Petros Martirosian, Nina F. Schwenzer, Michael Erb, Thomas Kuestner, Jakob Weiß, Ahmed Othman, Mike Notohamiprodjo, Konstantin Nikolaou, Christina Schraml

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 5/2016

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Abstract

Objective

To evaluate simultaneous multislice (sms) accelerated diffusion-weighted imaging (DWI) of the liver in comparison to conventional sequences.

Materials and methods

Ten volunteers underwent DWI of the liver at 1.5 T. Four different sms-accelerated sequences with monopolar and bipolar gradient preparation (MP, BP) and acceleration factors 2 and 3 (sms2-DWI, sms3-DWI) were compared to conventional DWI (c-DWI). Image quality criteria rated on a 5-point Likert scale (5 = excellent), image quality sum scores (maximum 120), and ADC were compared using Friedman test and Dunn-Bonferroni post hoc test. Bland–Altman plots were calculated for ADC comparison. p values <0.05 were considered significant.

Results

Sms2-DWI offered scan time minimization of 67 % without significant difference in image quality (sum score: sms2-DWI MP/BP: 97 ± 8/92 ± 9; c-DWI MP/BP: 99 ± 8/97 ± 8). Sms3-DWI offered slight additional scan time minimization with significantly inferior image quality (sum score: sms3-DWI MP/BP: 75 ± 14/69 ± 14; p < 0.001). MP preparation provided slightly higher image quality in sms-DWI without statistical significance. ADC in sms-DWI were significantly lower (sms2-DWI MP 1.01 × 10−3 mm2/s; c-DWI MP 1.20 × 10−3 mm2/s; p < 0.001).

Conclusion

Sms2-DWI provides considerable scan time minimization without significant shortcomings in image quality. Sms3-DWI provides significantly inferior image quality without further scan time minimization. Potentially lower ADC in sms-DWI should be considered in clinical routine.
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Literature
2.
3.
go back to reference Wagner M, Doblas S, Daire JL, Paradis V, Haddad N, Leitao H, Garteiser P, Vilgrain V, Sinkus R, Van Beers BE (2012) Diffusion-weighted MR imaging for the regional characterization of liver tumors. Radiology 264(2):464–472CrossRefPubMed Wagner M, Doblas S, Daire JL, Paradis V, Haddad N, Leitao H, Garteiser P, Vilgrain V, Sinkus R, Van Beers BE (2012) Diffusion-weighted MR imaging for the regional characterization of liver tumors. Radiology 264(2):464–472CrossRefPubMed
5.
go back to reference Filipe JP, Curvo-Semedo L, Casalta-Lopes J, Marques MC, Caseiro-Alves F (2013) Diffusion-weighted imaging of the liver: usefulness of ADC values in the differential diagnosis of focal lesions and effect of ROI methods on ADC measurements. Magn Reson Mater Phys 26(3):303–312CrossRef Filipe JP, Curvo-Semedo L, Casalta-Lopes J, Marques MC, Caseiro-Alves F (2013) Diffusion-weighted imaging of the liver: usefulness of ADC values in the differential diagnosis of focal lesions and effect of ROI methods on ADC measurements. Magn Reson Mater Phys 26(3):303–312CrossRef
6.
go back to reference Feinberg DA, Moeller S, Smith SM, Auerbach E, Ramanna S, Gunther M, Glasser MF, Miller KL, Ugurbil K, Yacoub E (2010) Multiplexed echo planar imaging for sub-second whole brain FMRI and fast diffusion imaging. PLoS One 5(12):e15710CrossRefPubMedPubMedCentral Feinberg DA, Moeller S, Smith SM, Auerbach E, Ramanna S, Gunther M, Glasser MF, Miller KL, Ugurbil K, Yacoub E (2010) Multiplexed echo planar imaging for sub-second whole brain FMRI and fast diffusion imaging. PLoS One 5(12):e15710CrossRefPubMedPubMedCentral
7.
go back to reference Lau AZ, Tunnicliffe EM, Frost R, Koopmans PJ, Tyler DJ, Robson MD (2015) Accelerated human cardiac diffusion tensor imaging using simultaneous multislice imaging. Magn Reson Med 73(3):995–1004CrossRefPubMed Lau AZ, Tunnicliffe EM, Frost R, Koopmans PJ, Tyler DJ, Robson MD (2015) Accelerated human cardiac diffusion tensor imaging using simultaneous multislice imaging. Magn Reson Med 73(3):995–1004CrossRefPubMed
8.
go back to reference Obele CC, Glielmi C, Ream J, Doshi A, Campbell N, Zhang HC, Babb J, Bhat H, Chandarana H (2015) Simultaneous multislice accelerated free-breathing diffusion-weighted imaging of the liver at 3T. Abdom Imaging Obele CC, Glielmi C, Ream J, Doshi A, Campbell N, Zhang HC, Babb J, Bhat H, Chandarana H (2015) Simultaneous multislice accelerated free-breathing diffusion-weighted imaging of the liver at 3T. Abdom Imaging
9.
go back to reference Lewis S, Kamath A, Chatterji M, Patel A, Shyknevsky I, Dyvorne HA, Kuehn B, Taouli B (2015) Diffusion-weighted imaging of the liver in patients with chronic liver disease: comparison of monopolar and bipolar diffusion gradients for image quality and lesion detection. AJR 204(1):59–68CrossRefPubMed Lewis S, Kamath A, Chatterji M, Patel A, Shyknevsky I, Dyvorne HA, Kuehn B, Taouli B (2015) Diffusion-weighted imaging of the liver in patients with chronic liver disease: comparison of monopolar and bipolar diffusion gradients for image quality and lesion detection. AJR 204(1):59–68CrossRefPubMed
10.
go back to reference Kyriazi S, Blackledge M, Collins DJ, Desouza NM (2010) Optimising diffusion-weighted imaging in the abdomen and pelvis: comparison of image quality between monopolar and bipolar single-shot spin-echo echo-planar sequences. Eur Radiol 20(10):2422–2431CrossRefPubMed Kyriazi S, Blackledge M, Collins DJ, Desouza NM (2010) Optimising diffusion-weighted imaging in the abdomen and pelvis: comparison of image quality between monopolar and bipolar single-shot spin-echo echo-planar sequences. Eur Radiol 20(10):2422–2431CrossRefPubMed
11.
go back to reference Shimizu H, Isoda H, Fujimoto K, Kawahara S, Furuta A, Shibata T, Togashi K (2013) Comparison of acquired diffusion weighted imaging and computed diffusion weighted imaging for detection of hepatic metastases. Eur J Radiol 82(3):453–458CrossRefPubMed Shimizu H, Isoda H, Fujimoto K, Kawahara S, Furuta A, Shibata T, Togashi K (2013) Comparison of acquired diffusion weighted imaging and computed diffusion weighted imaging for detection of hepatic metastases. Eur J Radiol 82(3):453–458CrossRefPubMed
12.
go back to reference Dyvorne HA, Galea N, Nevers T, Fiel MI, Carpenter D, Wong E, Orton M, de Oliveira A, Feiweier T, Vachon ML, Babb JS, Taouli B (2013) Diffusion-weighted imaging of the liver with multiple b values: effect of diffusion gradient polarity and breathing acquisition on image quality and intravoxel incoherent motion parameters—a pilot study. Radiology 266(3):920–929CrossRefPubMedPubMedCentral Dyvorne HA, Galea N, Nevers T, Fiel MI, Carpenter D, Wong E, Orton M, de Oliveira A, Feiweier T, Vachon ML, Babb JS, Taouli B (2013) Diffusion-weighted imaging of the liver with multiple b values: effect of diffusion gradient polarity and breathing acquisition on image quality and intravoxel incoherent motion parameters—a pilot study. Radiology 266(3):920–929CrossRefPubMedPubMedCentral
13.
go back to reference Stejskal EOTJ (1965) Spin echoes in the presence of a time dependent gradient field. J Chem Phys 42:288CrossRef Stejskal EOTJ (1965) Spin echoes in the presence of a time dependent gradient field. J Chem Phys 42:288CrossRef
14.
go back to reference Reese TG, Heid O, Weisskoff RM, Wedeen VJ (2003) Reduction of eddy-current-induced distortion in diffusion MRI using a twice-refocused spin echo. Magn Reson Med 49(1):177–182CrossRefPubMed Reese TG, Heid O, Weisskoff RM, Wedeen VJ (2003) Reduction of eddy-current-induced distortion in diffusion MRI using a twice-refocused spin echo. Magn Reson Med 49(1):177–182CrossRefPubMed
15.
go back to reference Rosenkrantz AB, Geppert C, Kiritsy M, Feiweier T, Mossa DJ, Chandarana H (2015) Diffusion-weighted imaging of the liver: comparison of image quality between monopolar and bipolar acquisition schemes at 3T. Abdom Imaging 40(2):289–298CrossRefPubMed Rosenkrantz AB, Geppert C, Kiritsy M, Feiweier T, Mossa DJ, Chandarana H (2015) Diffusion-weighted imaging of the liver: comparison of image quality between monopolar and bipolar acquisition schemes at 3T. Abdom Imaging 40(2):289–298CrossRefPubMed
16.
go back to reference Larkman DJ, Hajnal JV, Herlihy AH, Coutts GA, Young IR, Ehnholm G (2001) Use of multicoil arrays for separation of signal from multiple slices simultaneously excited. J Magn Reson Imaging 13(2):313–317CrossRefPubMed Larkman DJ, Hajnal JV, Herlihy AH, Coutts GA, Young IR, Ehnholm G (2001) Use of multicoil arrays for separation of signal from multiple slices simultaneously excited. J Magn Reson Imaging 13(2):313–317CrossRefPubMed
17.
go back to reference Auerbach EJ, Xu J, Yacoub E, Moeller S, Ugurbil K (2013) Multiband accelerated spin-echo echo planar imaging with reduced peak RF power using time-shifted RF pulses. Magn Reson Med 69(5):1261–1267CrossRefPubMedPubMedCentral Auerbach EJ, Xu J, Yacoub E, Moeller S, Ugurbil K (2013) Multiband accelerated spin-echo echo planar imaging with reduced peak RF power using time-shifted RF pulses. Magn Reson Med 69(5):1261–1267CrossRefPubMedPubMedCentral
18.
go back to reference Moeller S, Yacoub E, Olman CA, Auerbach E, Strupp J, Harel N, Ugurbil K (2010) Multiband multislice GE-EPI at 7 tesla, with 16-fold acceleration using partial parallel imaging with application to high spatial and temporal whole-brain fMRI. Magn Reson Med 63(5):1144–1153CrossRefPubMedPubMedCentral Moeller S, Yacoub E, Olman CA, Auerbach E, Strupp J, Harel N, Ugurbil K (2010) Multiband multislice GE-EPI at 7 tesla, with 16-fold acceleration using partial parallel imaging with application to high spatial and temporal whole-brain fMRI. Magn Reson Med 63(5):1144–1153CrossRefPubMedPubMedCentral
19.
go back to reference Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33(1):159–174CrossRefPubMed Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33(1):159–174CrossRefPubMed
20.
go back to reference Cauley SF, Polimeni JR, Bhat H, Wald LL, Setsompop K (2014) Interslice leakage artifact reduction technique for simultaneous multislice acquisitions. Magn Reson Med 72(1):93–102CrossRefPubMed Cauley SF, Polimeni JR, Bhat H, Wald LL, Setsompop K (2014) Interslice leakage artifact reduction technique for simultaneous multislice acquisitions. Magn Reson Med 72(1):93–102CrossRefPubMed
21.
go back to reference Colagrande S, Pasquinelli F, Mazzoni LN, Belli G, Virgili G (2010) MR-diffusion weighted imaging of healthy liver parenchyma: repeatability and reproducibility of apparent diffusion coefficient measurement. J Magn Reson Imaging 31(4):912–920CrossRefPubMed Colagrande S, Pasquinelli F, Mazzoni LN, Belli G, Virgili G (2010) MR-diffusion weighted imaging of healthy liver parenchyma: repeatability and reproducibility of apparent diffusion coefficient measurement. J Magn Reson Imaging 31(4):912–920CrossRefPubMed
22.
go back to reference Sasaki M, Yamada K, Watanabe Y, Matsui M, Ida M, Fujiwara S, Shibata E (2008) Variability in absolute apparent diffusion coefficient values across different platforms may be substantial: a multivendor, multi-institutional comparison study. Radiology 249(2):624–630CrossRefPubMed Sasaki M, Yamada K, Watanabe Y, Matsui M, Ida M, Fujiwara S, Shibata E (2008) Variability in absolute apparent diffusion coefficient values across different platforms may be substantial: a multivendor, multi-institutional comparison study. Radiology 249(2):624–630CrossRefPubMed
23.
go back to reference Larsen NE, Haack S, Larsen LP, Pedersen EM (2013) Quantitative liver ADC measurements using diffusion-weighted MRI at 3 Tesla: evaluation of reproducibility and perfusion dependence using different techniques for respiratory compensation. Magn Reson Mater Phys 26(5):431–442CrossRef Larsen NE, Haack S, Larsen LP, Pedersen EM (2013) Quantitative liver ADC measurements using diffusion-weighted MRI at 3 Tesla: evaluation of reproducibility and perfusion dependence using different techniques for respiratory compensation. Magn Reson Mater Phys 26(5):431–442CrossRef
Metadata
Title
Scan time minimization in hepatic diffusion-weighted imaging: evaluation of the simultaneous multislice acceleration technique with different acceleration factors and gradient preparation schemes
Authors
Jana Taron
Petros Martirosian
Nina F. Schwenzer
Michael Erb
Thomas Kuestner
Jakob Weiß
Ahmed Othman
Mike Notohamiprodjo
Konstantin Nikolaou
Christina Schraml
Publication date
01-10-2016
Publisher
Springer Berlin Heidelberg
Published in
Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 5/2016
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI
https://doi.org/10.1007/s10334-016-0553-4

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