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Magnetic Resonance Materials in Physics, Biology and Medicine

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01-06-2015 | Research Article

In vivo proton magnetic resonance spectroscopic imaging of the healthy human brain at 9.4 T: initial experience

Authors: Grzegorz L. Chadzynski, Rolf Pohmann, Gunamony Shajan, Rupert Kolb, Sotirios Bisdas, Uwe Klose, Klaus Scheffler

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 3/2015

Abstract

Object

In this study, the feasibility of in vivo proton magnetic resonance spectroscopic imaging (¹H MRSI) of the healthy human brain at a field strength of 9.4 T, using conventional acquisition techniques, is examined and the initial experience is summarized.

Materials and methods

MRSI measurements were performed on a 9.4 T MR scanner (Siemens, Erlangen, Germany) equipped with head-only gradient insert (AC84, Siemens) and custom-developed, 8-channel transmit/24-channel receive, and 16-channel transmit/31-channel receive coils. Spectra were acquired from the superior part of the human brain with a modified STEAM sequence. Spectral quantification was done with LCModel software.

Results

Reasonable quality and signal-to-noise ratio of the acquired spectra allowed reliable quantification of 12 metabolites (Cramer-Rao lower bounds < 20 %), some of which may be difficult to quantify at field strengths below 7 T due to overlapping resonances or low concentrations.

Conclusion

While further developments are necessary to minimize chemical shift displacement and homogeneity of the transmit field, it is demonstrated that in vivo ¹H MRSI at a field strength of 9.4 T is possible. However, further studies applying up-to-date techniques to overcome high-field specific problems are needed in order to assess the potential gain in sensitivity that may be offered by MRSI at 9.4 T.

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Title: In vivo proton magnetic resonance spectroscopic imaging of the healthy human brain at 9.4 T: initial experience
Authors: Grzegorz L. Chadzynski
Rolf Pohmann
Gunamony Shajan
Rupert Kolb
Sotirios Bisdas
Uwe Klose
Klaus Scheffler
Publication date: 01-06-2015
Publisher: Springer Berlin Heidelberg
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 3/2015
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-014-0460-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

In vivo proton magnetic resonance spectroscopic imaging of the healthy human brain at 9.4 T: initial experience

Abstract

Object

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Object

Materials and methods

Results

Conclusion

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