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Magnetic Resonance Materials in Physics, Biology and Medicine

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01-02-2014 | Short Communication

Measurement of anesthetic uptake kinetics in the brain using ¹⁹F MRI and cross-correlation analysis after pulsed application

Authors: Maxim Terekhov, Alexander Scholz, Laura M. Schreiber

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 1/2014

Abstract

Object

We present a pilot study based on ¹⁹F-MRI to measure fast and slow wash-in and wash-out kinetics of volatile anesthetics in pig brain.

Method

The periodic administration of anesthetics in pulsed mode is used to enhance the sensitivity of the anesthetic concentration detection by ¹⁹F-MRI signal. Temporal correlation analysis allows mapping the kinetics time constants.

Results

The clear correlation response to anesthetics concentration changes was found in the brain region in comparison with fatty tissues.

Conclusion

The methodology may yield important pharmacological findings on regional effect of the anesthetics in brain and be a step towards human studies.

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Title: Measurement of anesthetic uptake kinetics in the brain using 19F MRI and cross-correlation analysis after pulsed application
Authors: Maxim Terekhov
Alexander Scholz
Laura M. Schreiber
Publication date: 01-02-2014
Publisher: Springer Berlin Heidelberg
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 1/2014
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-013-0380-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Measurement of anesthetic uptake kinetics in the brain using ¹⁹F MRI and cross-correlation analysis after pulsed application

Abstract

Object

Method

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Object

Method

Results

Conclusion

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