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Magnetic Resonance Materials in Physics, Biology and Medicine

Published in:

01-06-2012 | Short Communication

Lateralization of amygdala activation in fMRI may depend on phase-encoding polarity

Authors: Krystyna A. Mathiak, Mikhail Zvyagintsev, Hermann Ackermann, Klaus Mathiak

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 3/2012

Abstract

Object

Susceptibility artifacts along the phase-encoding (PE) direction impact the activation pattern in the amygdala and may lead to systematic asymmetries. We implemented a triple-echo echo-planar imaging (EPI) sequence, acquiring opposite PE polarities along left–right PE direction in a single shot, to investigate its effects on amygdala lateralization.

Materials and Methods

Twelve subjects viewed emotional faces to evoke amygdala activation.

Results and Conclusion

A region of interest analysis revealed that the lateralization of amygdala responses depended on the PE polarity thus representing a pure method artifact. Alternating PE with multi-echo EPI reduced the artifact. Lateralized fMRI activation in areas with magnetic field inhomogeneities need to be interpreted with caution.

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Title: Lateralization of amygdala activation in fMRI may depend on phase-encoding polarity
Authors: Krystyna A. Mathiak
Mikhail Zvyagintsev
Hermann Ackermann
Klaus Mathiak
Publication date: 01-06-2012
Publisher: Springer-Verlag
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 3/2012
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-011-0285-4

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Lateralization of amygdala activation in fMRI may depend on phase-encoding polarity

Abstract

Object

Materials and Methods

Results and Conclusion

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Springer Medicine

Abstract

Object

Materials and Methods

Results and Conclusion

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