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Clinical Autonomic Research

Published in:

01-02-2016 | Review Article

Autonomic dysfunction, immune regulation, and multiple sclerosis

Authors: Juan Manuel Racosta, Kurt Kimpinski

Published in: Clinical Autonomic Research | Issue 1/2016

Abstract

Objective

To review existing evidence regarding interactions between the autonomic nervous system and the immune system functions in multiple sclerosis.

Methods

We reviewed the literature regarding new insights linking autonomic dysfunction to immune deregulation in multiple sclerosis, with particular focus on the specific influence of sympathetic and parasympathetic dysfunction on inflammatory and neurodegenerative processes.

Results

Autonomic dysfunction is common in multiple sclerosis, representing a significant cause of disability. Several connections between pathologic immune pathways and the autonomic nervous system function were found.

Conclusions

Autonomic dysfunction may enhance inflammatory and neurodegenerative pathways that are of major importance in multiple sclerosis. Autonomic dysfunction can present with highly variable manifestations. Sympathetic and parasympathetic dysfunction displays different patterns in multiple sclerosis, with specific impact on inflammation and neurodegeneration.

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Title: Autonomic dysfunction, immune regulation, and multiple sclerosis
Authors: Juan Manuel Racosta
Kurt Kimpinski
Publication date: 01-02-2016
Publisher: Springer Berlin Heidelberg
Published in: Clinical Autonomic Research / Issue 1/2016
Print ISSN: 0959-9851
Electronic ISSN: 1619-1560
DOI: https://doi.org/10.1007/s10286-015-0325-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Autonomic dysfunction, immune regulation, and multiple sclerosis

Abstract

Objective

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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