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Published in:

01-05-2014 | Review Article

A ticking clock links metabolic pathways and organ systems function in health and disease

Authors: Manlio Vinciguerra, Maria Florencia Tevy, Gianluigi Mazzoccoli

Published in: Clinical and Experimental Medicine | Issue 2/2014

Abstract

Rhythmic variations with 24-h periodicity hallmark homeostatic regulation, metabolic processes and organ systems function, driven by a circadian timing system composed of central and peripheral oscillators. Recent reports suggest that disrupted circadian rhythmicity of physiology and behavior severely alters body homeostasis. Nuclear receptors and transcriptional regulators sense hormonal and metabolic cues and manage the rhythmic patterns of chromatin remodelling and gene expression, playing a key role in the cross talk between the circadian clock circuitry, the metabolic pathways and the organ systems. The alteration of this cross talk contributes to the pathophysiology of metabolic, degenerative, immune-related and neoplastic diseases.

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Title: A ticking clock links metabolic pathways and organ systems function in health and disease
Authors: Manlio Vinciguerra
Maria Florencia Tevy
Gianluigi Mazzoccoli
Publication date: 01-05-2014
Publisher: Springer Milan
Published in: Clinical and Experimental Medicine / Issue 2/2014
Print ISSN: 1591-8890
Electronic ISSN: 1591-9528
DOI: https://doi.org/10.1007/s10238-013-0235-8

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