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Published in:

01-02-2014 | Review Article

Therapeutic application of mesenchymal stem cells in bone and joint diseases

Authors: Yi Liu, Jianmei Wu, Youming Zhu, Jinxiang Han

Published in: Clinical and Experimental Medicine | Issue 1/2014

Abstract

Mesenchymal stem cells (MSCs), the non-hematopoietic progenitor cells, are multi-potent stem cells from a variety of tissues with the capability of self-renewal, proliferation, differentiation into multi-lineage cell types, as well as anti-inflammatory and immunomodulatory. These properties make MSCs an ideal source of cell therapy in bone and joint diseases. This review describes the advances of animal study and preliminary clinical application in the past few years, related to MSC-based cell therapy in the common bone and joint diseases, including osteoarthritis, rheumatoid arthritis, osteoporosis, osteonecrosis of the femoral head and osteogenesis imperfecta. It highlights the promising prospect of MSC in clinical application of bone and joint diseases.

Friedenstin AJ, Chailakhjan RK, Lalykina KS (1970) The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinetics 3:393–403

da Silva ML, Chagatelles PC, Nardi NB (2006) Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci 119:2204–2213

Campagnoli C, Roberts IA, Kumar S, Bennett PR, Bellantuono I, Fisk NM (2001) Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow. Blood 98:2396–2402PubMed

Kim JY, Jeon HB, Yang YS, Oh W, Chang JW (2010) Application of human umbilical cord blood-derived mesenchymal stem cells in disease models. World J Stem Cells 2:34–38PubMedCentralPubMed

Rodriguez AM, Elabd C, Amri EZ, Aihaud G, Dani C (2005) The human adipose tissue is a source of multipotent stem cells. Biochimie 87:125–128PubMed

Ilancheran S, Moodley Y, Manuelpillai U (2009) Human fetal membranes: a source of stem cells for tissue regeneration and repair? Placenta 30:2–10PubMed

Oh W, Kim DS, Yang YS, Lee JK (2008) Immunological properties of umbilical cord blood-derived mesenchymal stromal cells. Cell Immunol 251:116–123PubMed

Di Nicola M, Carlo-Stella C, Magni M, Milanesi M, Longoni PD, Matteucci P, Grisanti S, Gianni AM (2002) Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 99:3838–3843PubMed

Ren G, Su J, Zhang L, Zhao X, Ling W, L’huillie A, Zhang J, Lu Y, Roberts AI, Ji W, Zhang H, Rabson AB, Shi Y (2009) Species variation in the mechanisms of mesenchymall stem cell-mediated immunosuppression. Stem Cells 27:1954–1962PubMed

10.

Beyth S, Borovsky Z, Mevorach D, Liebergall M, Gazit Z, Aslan H, Galun E, Rachmilewitz J (2005) Human mesenchymal stem cells alter antigen-presenting cell maturation and induced T-cell unresponsiveness. Blood 105:2214–2219PubMed

11.

Gharbi M, Deberg M, Henrotin Y (2011) Application for proteomic techniques in studying osteoarthritis: a review. Front Physiol 2:90PubMedCentralPubMed

12.

Mokbel AN, El Tookhy OS, Shamaa AA, Rashed LA, Sabry D, El Sayed AM (2011) Homing and reparative effect of intra-articular injection of autologous mesenchymal stem cells in osteoarthritic animal model. BMC Musculoskelet Discord 12:259

13.

Aigner T, Rose J, Martin J, Buckwalter J (2004) Aging theories of primary osteoarthritis: from epidemiology to molecular biology. Rejuvenation Res 7:134–145PubMed

14.

Mobasheri A (2011) Applications of proteomics to osteoarthritis, a musculoskeletal disease characterized by aging. Front Physiol 2:108PubMedCentralPubMed

15.

Nöth U, Steinert AF, Tuan RS (2008) Technology Insight: adult mesenchymal stem cells for osteoarthritis therapy: delivery modes for Mesenchymal stem cells. Nat Clin Pract Rheumatol 4:371–380PubMed

16.

Ameye LG, Young MF (2006) Animal models of osteoarthritis: lessons learned while seeking the ‘Holy Grail’. Curr Opin Rheumatol 18:537–547PubMed

17.

Liu Y, Shu XZ, Prestwich GD (2006) Osteochondral defect repair with autologous bone marrow-derived mesenchymal stem cells in an injectable, in situ, cross-linked synthetic extracellular matrix. Tissue Eng 12:3405–3416PubMed

18.

Guo X, Wang X, Zhang Y, Xia R, Hu M, Duan C (2004) Repair of large articular cartilage defects with implants of autologous mesenchymal stem cells seeded into beta-tricalcium phosphate in a sheep model. Tissue Eng 10:1818–1829PubMed

19.

Hui JHP, Chen F, Thambyah A, Lee EH (2004) Treatment of chondral lesions in advanced osteochondritis dissecans: a comparative study of the efficacy of chondrocytes, mesenchymal stem cells, periosteal graft, and mosaicplasty (osteochondral autograft) in animal models. J Pediatr Orthop 24:427–433PubMed

20.

Yan H, Yu C (2007) Repair of full-thickness cartilage defects with cells of different origin in a rabbit model. Arthroscopy 23:178–187PubMed

21.

Kayakabe M, Tsutsumi S, Watanabe H, Kato Y, Takagishi K (2006) Transplantation of autologous rabbit BM-derived mesenchymal stromal cells embedded in hyaluronic acid gel sponge into osteochondral defects of the knee. Cytotherapy 8:343–353PubMed

22.

Kuroda R, Ishida K, Matsumoto T, Akisue T, Fujioka H, Mizuno K (2007) Treatment of a full-thickness articular cartilage defect in the femoral condyle of an athlete with autologous bone marrow stromal cells. Osteoarthritis Cartilage 15:226–231PubMed

23.

Lee KBL, Hui JHP, Song IC, Ardany L, Lee EH (2007) Injectable mesenchymal stem cell therapy for large cartilage defects-a porcine model. Stem Cells 25:2964–2971PubMed

24.

Murphy JM, Fink DJ, Hunziker EB, Barry FP (2003) Stem cell therapy in a caprine model of osteoarthritis. Arthritis Rheum 48:3464–3474PubMed

25.

26.

Sato M, Uchida K, Nakajima H, Miyazaki T, Guerrero AR, Watanabe S, Roberts S, Baba H (2012) Direct transplantation of mesenchymal stem cells into the knee joints of Hartley Strain guinea pig with spontaneous osteoarthritis. Arthritis Res Ther 14:R31PubMedCentralPubMed

27.

Horie M, Sekiya I, Muneta T, Ichinose S, Matsumoto K, Saito H, Murakami T, Kobayashi E (2009) Intra-articular injected synovial stem cells differentiate into meniscal cells directly and promote meniscal regeneration without mobilization of distant organs in rat massive meniscal defect. Stem Cells 27:878–887PubMed

28.

Fan J, Varshney RR, Ren L, Cai D, Wang DA (2009) Synovium-derived mesenchymal stem cells: a new cell source for musculoskeletal regeneration. Tissue Eng Part B Rev 15:75–86PubMed

29.

Koga H, Shimaya M, Muneta T, Nimura A, Morito T, Hayashi M, Suzuki S, Ju YJ, Mochizuki T, Sekiya I (2008) Local adherent technique for transplanting mesenchymal stem cells as a potential treatment of cartilage defect. Arthritis Res Ther 10:R84PubMedCentralPubMed

30.

Vishnubalaji R, Al-Nbaheen M, Kadalmani B, Aldahmash A, Ramesh T (2012) Comparative investigation of the differentiation capability of bone-marrow-and adipose-derived mesenchymal stem cells by qualitative and quantitative analysis. Cell Tissue Res 347:419–427PubMed

31.

Guilak F, Awad HA, Fermor B, Leddy HA, Gimble JM (2004) Adipose-derived adult stem cells for cartilage tissue engineering. Biorheology 41:389–399PubMed

32.

Black LL, Gaynor J, Gahring D, Adams C, Aron D, Harman S, Gingerich DA, Harman R (2007) Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: a randomized, double-blinded, multicenter, controlled trial. Veterinary Therapeutics 8:272–284PubMed

33.

Black LL, Gaynor J, Adams C, Dhupa S, Sams AE, Taylor R, Harman S, Gingerich DA, Harman R (2008) Effect of intraarticular injection of autologous adipose-derived mesenchymal stem and regenerative cells on clinical signs of chronic osteoarthritis of the elbow joint in dogs. Vet Ther 9:192–200PubMed

34.

Hou T, Xu J, Wu X, Xie Z, Luo F, Zhang Z, Zeng L (2009) Umbilical cord Wharton’s Jelly: a new potential cell source of mesenchymal stomal cells for bone tissue engineering. Tissue Eng Part A 15:2325–2334PubMed

35.

Fan CG, Zhang QJ, Zhou JR (2011) Therapeutic potentials of mesenchymal stem cells derived from human umbilical cord. Stem Cell Rev 7:195–207PubMed

36.

Wang L, Tran I, Seshareddy K, Weiss ML, Detamore MS (2009) A comparison of human bone marrow-derived mesenchymal stem cells and human umbilical cord-derived mesenchymal stromal cells for cartilage tissue engineering. Tissue Eng Part A 15:2259–2266PubMed

37.

Fong CY, Subramanian A, Gauthaman K, Venugopal J, Biswas A, Ramakrishna S, Bongso A (2012) Human umbilical cord Whaton’s Jelly stem cells undergo enhanced chondrogenic differentiation when grown on nanofibrous scaffolds and in a sequential two-stage culture medium environment. Stem Cell Rev 8:195–209PubMed

38.

Huang K, Zhang C, Zhang XW, Bao JP, Wu LD (2011) Effect of dehydroepiandrosterone on aggrecanase expression in articular cartilage in a rabbit model of osteoarthritis. Mol Biol Rep 38:3569–3572PubMed

39.

Wakitani S, Imoto K, Yamamoto T, Saito M, Murata N, Yoneda M (2002) Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knee. Osteoarthritis Cartilage 10:199–206PubMed

40.

Ohgushi H, Kotobuki N, Funaoka H, Machida H, Hirose M, Tanaka Y, Takakura Y (2005) Tissue engineered ceramic artificial joint-ex vivo osteogenic differentiation of patient mesenchymal cells on total ankle joints for treatment of osteoarthritis. Biomaterials 26:4654–4661PubMed

41.

Pak J (2011) Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose-tissue-derived stem cells: a case series. J Med Case Rep 5:296PubMedCentralPubMed

42.

Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, Karli D (2008) Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Pain Physician 11:343–353PubMed

43.

Davatchi F, Abdollahi BS, Mohyeddin M, Shahram F, Nikbin B (2011) Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients. Int J Rheum Dis 14:211–215PubMed

44.

Fournier C (2005) Where do T cells stand in rheumatoid arthritis? Joint Bone Spine 72:527–532PubMed

45.

Firestein GS (2003) Evolving concepts of rheumatoid arthritis. Nature 423:356–361PubMed

46.

Gonzalez MA, Gonzalez-Rey E, Rico L, Buscher D, Delgado M (2009) Treatment of experimental arthritis by inducing immune tolerance with human adipose-derived mesenchymal stem cells. Arthritis Rheum 60:1006–1019PubMed

47.

Fox DA (1997) The role of T cells in the immunopathogenesis of rheumatoid arthritis: new perspectives. Arthritis Rheum 40:598–609PubMed

48.

Ren G, Zhang L, Zhao X, Xu G, Zhang Y, Roberts AI, Zhao RC, Shi Y (2008) Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell 2:141–150PubMed

49.

MacDonal GI, Augello A, De Bari C (2011) Role of mesenchymal stem cells in reestablishing immunologic tolerance in autoimmune rheumatic diseases. Arthritis Rheum 63(9):2547–2557

50.

Djouad F, Fritz V, Apparailly F, Louis-Plence P, Bony C, Sany J, Jorgensen C, Noel D (2005) Reversal of the immunosuppressive properties of mesenchymal stem cells by tumor necrosis factor alpha in collagen-induced arthritis. Arthritis Rheum 52:1595–1603PubMed

51.

Schurgers E, Kelchtermans H, Mitera T, Geboes L, Matthys P (2010) Discrepancy between the in vitro and in vivo effect of murine mesenchymal stem cells on T-cell proliferation and collagen-induced arthritis. Arthritis Res Therapy 12:R31

52.

Chen B, Hu J, Liao L (2010) Flk-1 + mesenchymal stem cells aggravate collagen-induced arthritis by up-regulating interleukin-6. Clin Exp Immunol 159:292–302PubMedCentralPubMed

53.

Augello A, Tasso R, Negrini SM, Cancedda R, Pennesi G (2007) Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis. Arthritis Rheum 56:1175–1186PubMed

54.

GonZalez MA, Gonzalez-Rey E, Rico L, Buscher D, Delgado M (2009) Treatment of experimental arthritis by inducing immune tolerance with human adipose-derived mesenchymal stem cells. Arthritis Rheum 60:1006–1019PubMed

55.

Gonzalez-Rey E, Gonzalez MA, Varela N, O’Valle F, Hernandez-Cortes P, Rico L, Buscher D, Delgado M (2010) Human adipose-derived mesenchymal stem cells reduce inflammatory and T cell responses and induce regulatory T cells in vitro in rheumatoid arthritis. Ann Rheum Dis 69:241–248PubMed

56.

Zhou B, Yuan J, Zhou Y, Ghawji M Jr, Deng YP, Lee AJ, Lee AJ, Nair U, Kang AH, Brand DD, Yoo TJ (2011) Administering human adipose-derived stem cells to prevent and treat experimental arthritis. Clin Immunol 141:328–337PubMed

57.

Liu Y, Mu R, Wang S, Long L, Liu X, Li R, Sun J, Guo J, Zhang X, Guo J, Yu P, Li C, Liu X, Huang Z, Wang D, Li H, Gu Z, Liu B, Li Z (2010) Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis. Arthritis Res Ther 12:R210PubMedCentralPubMed

58.

Choi JJ, Yoo SA, Park SJ, Kang YJ, Kim WU, Oh IH, Cho CS (2008) Mesenchymal stem cells overexpressing interleukin-10 attenuate collagen-induced arthritis in mice. Clin Exp Immunol 153:269–276PubMedCentralPubMed

59.

Park MJ, Park HS, Cho ML, Oh HJ, Cho YG, Min SY, Chung BH, Lee JW, Kim HY, Cho SG (2011) Transforming growth factor β-transduced mesenchymal stem cells ameliorate experimental autoimmune arthritis through reciprocal regulation of Treg/Th17 cells and osteoclastogenesis. Arthritis Rheum 63:1668–1680PubMed

60.

Ra JC, Kang SK, Shin IS, Park HG, Joo SA, Kim JG, Kang BC, Lee YS, Nakama K, Piao M, Sohl B, Kurtz A (2011) Stem cell treatment for patients with autoimmune disease by systemic infusion of culture-expanded autologous adipose tissue derived mesenchymal stem cells. J Transl Med 9:181PubMedCentralPubMed

61.

Liang J, Li X, Zhang H, Wang D, Feng X, Wang H, Hua B, Liu B, Sun L (2012) Allogeneic mesenchymal stem cells transplantation in patients with refractory RA. Clin Rheumatol 31:157–161PubMed

62.

Peng KY, Horing LY, Sung HC, Huang HC, Wu RT (2011) Antiosteoporotic activity of dioscorea alata L.cv. Phyto through driving mesenchymal stem cells differentiation for bone formation. Evid Based Complement Alternat Med 2011:712892PubMedCentralPubMed

63.

Raisz LA (2005) Pathogenies of osteoporosis: concepts, conflicts, and prospects. J Clin Invest 115:3318–3325PubMedCentralPubMed

64.

Wang Z, Goh J, De Das S, Ge Z, Ouyang H, Chong JS, Low SL, Lee EH (2006) Efficacy of bone marrow-derived stem cells in strengthening osteoporotic bone in a rabbit model. Tissue Eng 12:1753–1761PubMed

65.

Turgeman G, Aslan H, Gazit Z, Gazit D (2002) Cell-mediated gene therapy for bone formation and regeneration. Curr Opin Mol Ther 4:390–394PubMed

66.

Bruder SP, Fink DJ, Caplan AI (1994) Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy. J Cell Biochem 56:283–294PubMed

67.

Nuttall ME, Patton AJ, Olivera DJ, Nadeau DP, Gowen M (1998) Human trabecular bone cells are able to express both osteoblastic and adipocytic phenotype: implications for osteopenic disorders. J Bone Miner Res 13:371–382PubMed

68.

Turgeman G, Zilberman Y, Zhou S, Kelly P, Moutsatsos IK, Kharode YP, Borella LE, Bex FJ, Komm BS, Bodine PV, Gazit D (2002) Systemically administered rh BMP-2 promotes MSC activity and reverses bone and cartilage loss in osteopenic mice. J Cell Biochem 86:461–474PubMed

69.

Zhou S, Zilberman Y, Wassermann K, Bain SD, Sadovsky Y, Gazit D (2001) Estrogen modulates estrogen receptor alpha and beta expression, osteogenic activity, and apoptosis in mesenchymal stem cells (MSCs) of osteoporotic mice. J Cell Biochem Suppl 36(Suppl):144–155PubMed

70.

Ocarino Nde M, Boeloni JN, Jorgetti V, Gomes DA, Goes AM, Serakides R (2010) Intra-bone marrow injection of mesenchymal stem cells improves the femur bone mass of osteoporotic female rats. Connect Tissue Res 51:426–433PubMed

71.

Egermann M, Gerhardt C, Barth A, Maestroni GJ, Schnerder E, Alini M (2011) Pinealectomy affects bone mineral density and structure-an experimental study in sheep. BMC Musculoskelet Disord 12:271PubMedCentralPubMed

72.

Jerome C, Missbach M, Gamse R (2011) Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys. Osteoporos Int 22:3001–3011PubMed

73.

Tang YC, Tang W, Tian WD, Chen XZ, Li SW (2006) A study on repairing mandibular defect by means of tissue-engineering and human bone morphogenetic protein-2 gene transfection in osteoporotic rats. Zhonghua Kou Qiang Yi Xue Za Zhi 41:430–431PubMed

74.

Hsiao FS, Cheng CC, Peng SY, Huang HY, Lian WS, Jan ML, Fang YT, Cheng EC, Lee KH, Cheng WT, Lin SP, Wu SC (2010) Isolation of therapeutically functional mouse bone marrow mesenchymal stem cells within 3 h by an effective single-step plastic-adherent method. Cell Prolif 43:235–248PubMed

75.

Bianco P, Riminucci M, Gronthos S, Robey PG (2001) Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells 19:180–192PubMed

76.

Kanakaris NK, Petsatodis G, Tagil M, Giannoudis PV (2009) Is there a role for bone morphogenetic proteins in osteoporotic fractures? Injury 40(Suppl 3):S21–S26PubMed

77.

Turgeman G, Pittman DD, Muller R, Kurkalli BG, Zhou S, Pelled G, Peyser A, Ziberman Y, Moutsatsos IK, Gazit D (2001) Engineered human mesenchymal stem cells: a novel platform for skeletal cell mediated gene therapy. J Gene Med 3:240–251PubMed

78.

Egermann M, Baltzer AW, Adamaszek S, Evans C, Robbins P, Schneider E, Lill CA (2006) Direct adenoviral transfer of bone morphogenetic protein-2 cDNA enhances fracture healing in osteoporotic sheep. Hum Gene Ther 17:507–517PubMed

79.

Kumar S, Mahendra G, Nagy TR, Ponnazhagan S (2004) Osteogenic differentiation of recombinant adeno-associated virus 2-transduced murine mesenchymal stem cells and development of an immunocompetent mouse model for ex vivo osteoporosis gene therapy. Hum Gene Ther 15:1197–1206PubMed

80.

Zhang XS, Linkhart TA, Chen ST, Peng H, Wergedal JE, Guttierez GG, Sheng MH, Lau KH, Baylink DJ (2004) Local ex vivo gene therapy with bone marrow stromal cells expressing human BMP4 promotes endosteal bone formation in mice. J Gene Med 6:4–15PubMed

81.

Hu J, Qi MC, Zou SJ, Li JH, Luo E (2007) Callus formation enhanced by BMP-7 ex vivo gene therapy during distraction osteogenesis in rats. J Orthop Res 25:241–251PubMed

82.

Dumon RJ, Dyoub H, Li JZ, Dumont AS, Kallmes DF, Hankins GR, Helm GA (2002) Ex vivo bone morphogenetic protein-9 gene therapy using human mesenchymal stem cells induces spinal fusion in rodents. Neurosurgery 51:1239–1245

83.

Kim D, Cho SW, Her SJ, Yang JY, Kim SW, Kim SY, Shin CS (2006) Retrovirus-mediated gene transfer of receptor activator of nuclear factor-kappaB-Fc prevents bone loss in ovariectomized mice. Stem Cells 24:1798–1805PubMed

84.

Cho SW, Sun HJ, Yang JY, Jung JY, An JH, Cho HY, Choi HJ, Kim SW, Kim SY, Kim D, Shin CS (2009) Transplantation of mesenchymal stem cells overexpressing RANK-Fc or CXCR4 prevents bone loss in ovariectomized mice. Mol Ther 17:1979–1987PubMed

85.

Lien CY, Chih-Yuan Ho K, Lee OK, Blunn GW, Su Y (2009) Restoration of bone mass and strength in glucocorticoid-treated mice by systemic transplantation of CXCR4 and cbfa-1 co-expressing mesenchymal stem cells. J Bone Miner Res 24:837–848PubMed

86.

Chen HT, Lee MJ, Chen CH et al (2012) Proliferation and differentiation potential of human adipose-derived mesenchymal stem cells isolated from elderly patients with osteoporotic fractures. J Cell Mol Med 16:582–593PubMed

87.

Wang CJ, Wang FS, Huang CC, Yang KD, Weng LH, Huang HY (2005) Treatment for osteonecrosis of the femoral head: comparison of extracorporeal shock waves with core decompression and bone-grafting. J Bone Joint Surg Am 87:2380–2387PubMed

88.

Feitosa ML, Fadel L, Beltrao-Braga PC et al (2010) Successful transplant of mesenchymal stem cells in induced osteonecrosis of the ovine femoral head: preliminary results. Acta Cir Bras 25:416–422PubMed

89.

Chan TW, Dalinka MK, Steinberg ME, Kressel HY (1991) MRI appearance of femoral head osteonecrosis following core decompression and bone grafting. Skeletal Radiol 20:103–107PubMed

90.

Wassenaar RP, Verburg H, Taconis WK, van der Eijken JW (1996) Avascular osteonecrosis of the femoral head treated with a vascularized iliac bone graft: preliminary results and follow-up with radiography and MR imaging. Radiographics 16:585–594PubMed

91.

Hernigou P, Beaujean F (2002) Treatment of osteonecrosis with autologous bone marrow grafting. Clin Orthop 405:14–23PubMed

92.

Hernigou P, Manicom O, Poignard A et al (2004) Core decompression with marrow stem cells. Operative Tech Orthop 14:68–74

93.

Gangji V, Hauzeur JP, Matos C, De Maertelaer V, Toungouz M, Lambermont M (2004) Treatment of osteonecrosis of the femoral head with implantation of autologous bone-marrow cells. A pilot study. J Bone Joint Surg Am 86-A:1153–1160PubMed

94.

Wang BL, Sun W, Shi ZC et al (2010) Treatment of nontraumatic osteonecrosis of the femoral head with the implantation of core decompression and concentrated autologous bone marrow containing mononuclear cells. Arch Orthop Trauma Surg 130:859–865PubMed

95.

Hernigou P, Poignard A, Zilber S, Rouard H (2009) Cell therapy of hip osteonecrosis with autologous bone marrow grafting. Indian J Orthop 43:40–45PubMedCentralPubMed

96.

GangJi V, De Maertelaer V, Hauzeur JP (2011) Autologous bone marrow cell implantation in the treatment of non-traumatic osteonecrosis of the femoral head: five year follow-up of a prospective controlled study. Bone 49:1005–1009PubMed

97.

Hernigou P (1998) Growth factors released from bone marrow are promising tools in orthopedic surgery. Rev Rhum Engl Ed 65:79–84PubMed

98.

Noel D, Djouad F, Jorgense C (2002) Regenerative medicine through mesenchymal stem cells for bone and cartilage repair. Curr Opin Investig Drugs 3:1000–1004PubMed

99.

Kuo TK, Ho JH, Lee OK (2009) Mesenchymal stem cell therapy for nonmusculoskeletal diseases: emerging applications. Cell Transplant 18:1013–1028PubMed

100.

Cui Q, Xiao Z, Li X, Saleh KJ, Balian G (2006) Use of genetically engineered bone-marrow stem cells to treat femoral defects: an experimental study. J Bone Joint Surg Am 88(Suppl 3):167–172PubMed

101.

Matsuya H, Kushida T, Asada T, Umeda M, Wada T, Iida H (2008) Regenerative effects of transplanting autologous mesenchymal stem cells on corticosteroid-induced osteonecrosis in rabbits. Mod Rhheumatol 18:132–139

102.

Li ZH, Liao W, Cui XL et al (2011) Intravenous transplantation of allogeneic bone marrow mesenchymal stem cells and its directional migration to the necrotic femoral head. Int J Med Sci 8:74–83PubMedCentralPubMed

103.

Yan Z, Hang D, Guo C, Chen Z (2009) Fate of mesenchymal stem cells transplanted to osteonecrosis of femoral head. J Orthop Res 27:442–446PubMed

104.

Peng J, Wen C, Wang A et al (2011) Micro-CT-based bone ceramic scaffolding and its performance after seeding with mesenchymal stem cells for repair of load-bearing bone defect in canine femoral head. J Biomed Mater Res B Appl Biomater 96:316–325PubMed

105.

106.

Yang J, Wang L, Xu Y, Wang J, Wang Y (2008) An experimental study on treatment of steroid-associated femoral head necrosis with simvastatin and BMSCs transplantation. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 22:290–294PubMed

107.

Wen Q, Zhou L, Zhou C, Zhou M, Luo W, Ma L (2012) Change in hepatocyte growth factor concentration promote mesenchymal stem cell-mediated osteogenic regeneration. J Cell Mol Med 16:1260–1273PubMed

108.

Liu BY, Zhao DW (2009) Treatment for osteonecrosis of femoral head by hVEGF-165 gene modified marrow stromal stem cells under arthroscope. Zhonghua Yi Xue Za Zhi 89:2629–2633PubMed

109.

Zhang C, Wang KZ, Qiang H et al (2010) Angiopoiesis and bone regeneration via co-expression of the hVEGF and hBMP genes from an adeno-associated viral vector in vitro and in vivo. Acta Pharmacol Sin 31:821–830PubMed

110.

Shi ZB, Wang KZ (2010) Effects of recombinant adeno-associated viral vectors on angiopoiesis and osteogenesis in cultured rabbit bone marrow stem cells via co-expressing hVEGF and hBMP genes: a preliminary study in vitro. Tissue Cell 42:314–321PubMed

111.

Zhang C, Ma Q, Qiang H, Li M, Dang X, Wang K (2010) Study on effect of recombinant adeno-associated virus co-expressing human vascular endothelial growth factor 165 and human bone morphogenetic protein 7 genes on bone regeneration and angiopoiesis in vivo. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 24:1449–1454PubMed

112.

Tang TT, Lu B, Yue B et al (2007) Treatment of osteonecrosis of the femoral head with hBMP-2-gene-modified tissue-engineered bone in goats. J Bone Joint Surg Br 89:127–129PubMed

113.

Xiao ZM, Jiang H, Zhan XL, Wu ZG, Zhang XL (2008) Treatment of osteonecrosis of femoral head with BMSCs-seeded bio-derived bone materials combined with rhBMP-2 in rabbits. Chin J Traumatol 11:165–170PubMed

114.

Chang T, Tang K, Tao X et al (2010) Treatment of early avascular necrosis of femoral head by core decompression combined with autologous bone marrow mesenchymal stem cells transplantation. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 24:739–743PubMed

115.

Zhao D, Cui D, Wang B et al (2012) Treatment of early stage osteonecrosis of the femoral head with autologous implantation of bone marrow-derived and cultured mesenchymal stem cells. Bone 50:325–330PubMed

116.

Pak J (2012) Autologous adipose tissue-derived stem cells induce persistent bone-like tissue in osteonecrotic femoral heads. Pain Physician 15:75–85PubMed

117.

Byers PH, Wallis GA, Willing MC (1991) Osteogenesis imperfecta: translation of mutation to phenotype. J Med Genet 28:433–442PubMed

118.

Cabral WA, Marini JC (2004) High proportion of mutant osteoblasts is compatible with normal skeletal function in mosaic carriers of osteogenesis imperfecta. Am J Hum Genet 74:752–760PubMedCentralPubMed

119.

Millington-Ward S, Allers C, Tuohy G et al (2002) Validation in mesenchymal progenitor cells of a mutation-independent ex vivo approach to gene therapy for osteogenesis imperfecta. Hum Mol Gent 11:2201–2206

120.

Caplan AI (1995) Osteogenesis imperfecta, rehabilitation medicine, fundamental research and mesenchymal stem cells. Connect Tissue Res 31:S9–S14PubMed

121.

Pereira RF, O’Hara MD, Laptev AV et al (1998) Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta. Pro Natl Acad Sci USA 95:1142–1147

122.

Guillot PV, Abass O, Bassett JH et al (2008) Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice. Blood 111:1717–1725PubMed

123.

Horwitz EM, Prockop DJ, Fitzpatrick LA et al (1999) Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med 5:309–313PubMed

124.

Horwitz EM, Prockop DJ, Gordon PL et al (2001) Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta. Blood 97:1227–1231PubMed

125.

Horwitz EM, Gordon PL, Koo WK et al (2002) Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone. Proc Natl Acad Sci USA 99:8932–8937PubMed

126.

Le Blanc K, Gotherstrom C, Ringden O et al (2005) Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patients with severe osteogenesis imperfecta. Transplantation 79:1607–1614PubMed

127.

Millington-Ward S, McMahon HP, Allen D et al (2004) RNAi of COL1A1 in mesenchymal progenitor cells. Eur J Hum Genet 12:864–866PubMed

128.

Ljunggren O, Lindahl K, Rubin CJ, Kindmark A (2011) Allele-specific gene silencing in osteogenesis imperfecta. Endocr Dev 21:85–90PubMed

129.

Jaganathan BG, Bonnet D (2012) Human mesenchymal stromal cells senesce with exogenous OCT4. Cytotherapy 14:1054–1063PubMed

130.

Symonds CE, Galderisi U, Giordano A (2009) Aging of the inceptive cellular population: the relationship between stem cells and aging. Aging (Albany NY) 1:372–381

131.

Galderisi U, Helmbold H, Squillaro T, Alessio N, Komm N, Khadang B, Cipollaro M, Bohn W, Giordano A (2009) In vitro senescence of rat mesenchymal stem cell is accompanied by downregulation of stemness-related and DNA damage repair genes. Stem Cells Dev 18:1033–1042PubMed

132.

Liu TM, Ng WM, Tan HS, Vinitha D, Yang Z, Fan JB, Zou Y, Hui JH, Lee EH, Lim B (2012) Molecular basis of immortalization of human mesenchymal stem cells by combination of p53 knockdown and human telomerase reverse transcriptase overexpression. Stem Cells Dev Aug 21 [Epub ahead of print]

Title: Therapeutic application of mesenchymal stem cells in bone and joint diseases
Authors: Yi Liu
Jianmei Wu
Youming Zhu
Jinxiang Han
Publication date: 01-02-2014
Publisher: Springer Milan
Published in: Clinical and Experimental Medicine / Issue 1/2014
Print ISSN: 1591-8890
Electronic ISSN: 1591-9528
DOI: https://doi.org/10.1007/s10238-012-0218-1

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