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Journal of Orthopaedics and Traumatology

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Open Access 01-12-2009 | Original Article

Pregabalin, celecoxib, and their combination for treatment of chronic low-back pain

Authors: Carlo Luca Romanò, Delia Romanò, Cristina Bonora, Giuseppe Mineo

Published in: Journal of Orthopaedics and Traumatology | Issue 4/2009

Abstract

Background

The efficacy and safety of the association of celecoxib [a selective cyclooxygenase-2 (COX-2) inhibitor] and pregabalin (commonly used to control neuropathic pain), compared with monotherapy of each, were evaluated for the treatment of chronic low-back pain, a condition known to be due to neuropathic as well as nociceptive pain mechanisms.

Materials and methods

In this prospective randomized trial, 36 patients received three consecutive 4-week treatment regimes, randomly assigned: celecoxib plus placebo, pregabalin plus placebo, and celecoxib plus pregabalin. All patients were assessed by using a visual analogue scale (VAS, 0–100 mm) and the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) pain scale by an investigator blinded to the administered pharmacological treatment.

Results

Celecoxib and pregabalin were effective in reducing low-back pain when patients were pooled according to LANSS score. The association of celecoxib and pregabalin was more effective than either monotherapy in a mixed population of patients with chronic low-back pain and when data were pooled according to LANSS score. Adverse effects of drug association and monotherapies were similar, with reduced drug consumption in the combined therapy.

Conclusions

Combination of celecoxib and pregabalin is more effective than monotherapy for chronic low-back pain, with similar adverse effects.

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Title: Pregabalin, celecoxib, and their combination for treatment of chronic low-back pain
Authors: Carlo Luca Romanò
Delia Romanò
Cristina Bonora
Giuseppe Mineo
Publication date: 01-12-2009
Publisher: Springer International Publishing
Published in: Journal of Orthopaedics and Traumatology / Issue 4/2009
Print ISSN: 1590-9921
Electronic ISSN: 1590-9999
DOI: https://doi.org/10.1007/s10195-009-0077-z

2024 ASCO Annual Meeting

Springer Medicine

Pregabalin, celecoxib, and their combination for treatment of chronic low-back pain

Abstract

Background

Materials and methods

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Materials and methods

Results

Conclusions

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