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Open Access 01-02-2010 | Original

Lack of association between five serotonin metabolism-related genes and medication overuse headache

Authors: Sabina Cevoli, Nadia Marzocchi, Sabina Capellari, Chiara Scapoli, Giulia Pierangeli, Daniela Grimaldi, Federica Naldi, L. Alberto Pini, Pasquale Montagna, Pietro Cortelli

Published in: The Journal of Headache and Pain | Issue 1/2010

Abstract

Serotonin is involved in several central nervous system functions including pain threshold, mood regulation and drug reward. Overuse of acute medications is commonly identified as a causative factor for medication overuse headache (MOH). Apparently, MOH shares with other kinds of drug addiction some common neurobiological pathways. The objective of this study is to assess the role of serotonin metabolism genes in the genetic liability to MOH. We performed a genetic association study using polymorphisms of five serotonin metabolism-related genes: serotonin transporter (5HTT), serotonin receptor 1A (5-HT1A), serotonin receptor 1B (5-HT1B), serotonin receptor 2A (5-HT2A) and serotonin receptor 6 (5HT6) genes. We compared 138 patients with MOH with a control sample of 117 individuals without headache and without drug overuse, and with 101 patients with migraine without aura but without drug overuse (MO). The genotypic and allelic distributions of all polymorphisms investigated did not differ among the three groups. In conclusion, our study does not provide evidence that the 5HTT, 5-HT1A, 5HT1B, 5HT2A and 5HT6 gene polymorphisms play a role in the genetic predisposition to MOH.

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Title: Lack of association between five serotonin metabolism-related genes and medication overuse headache
Authors: Sabina Cevoli
Nadia Marzocchi
Sabina Capellari
Chiara Scapoli
Giulia Pierangeli
Daniela Grimaldi
Federica Naldi
L. Alberto Pini
Pasquale Montagna
Pietro Cortelli
Publication date: 01-02-2010
Publisher: Springer Milan
Published in: The Journal of Headache and Pain / Issue 1/2010
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1007/s10194-009-0168-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Lack of association between five serotonin metabolism-related genes and medication overuse headache

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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