Skip to main content
Top
Published in: The Journal of Headache and Pain 1/2009

Open Access 01-02-2009 | Original

GERD prevalence in migraine patients and the implication for acute migraine treatment

Authors: Božena J. Katić, Wendy Golden, Roger K. Cady, X. Henry Hu

Published in: The Journal of Headache and Pain | Issue 1/2009

Login to get access

Abstract

The objective of this study is to estimate the prevalence of gastroesophageal reflux disease (GERD) and heartburn in migraine patients and examine their use of non-steroidal anti-inflammatory drugs (NSAIDs) or aspirin-containing medications when treating acute migraine attacks. Responses from a web-based survey of migraine patients were matched to the same patient’s responses on a general health survey. A total of 1,832 migraineurs (92.0%) were successfully matched. A total of 403 migraineurs (22.0%) reported having diagnosed GERD, 212 (11.6%) reported diagnosed heartburn, and 290 (15.8%) reported reflux symptoms but were undiagnosed. The most common prescription drugs used to treat migraines were triptans. First-line NSAID/aspirin medication use was 10.0% among diagnosed GERD and heartburn patients, 17.8% among undiagnosed patients, and 11.8% among GERD/heartburn-free migraineurs. In conclusion, almost half of migraineurs reported physician-diagnosed GERD and heartburn or symptoms of these conditions. Use of NSAID medications for migraine is fairly common among diagnosed GERD patients and more so for those with undiagnosed GERD symptoms. Physicians should minimize prescribing NSAIDs or NSAID-containing acute migraine medications in this population.
Literature
1.
go back to reference Diamond S, Bigal ME, Silberstein S, Loder E, Reed M, Lipton RB (2006) Patterns of diagnosis and acute and preventive treatment for migraine in the United States: results from the American Migraine Prevalence and Prevention study. Headache J Head Face Pain 47(3):355–363 Diamond S, Bigal ME, Silberstein S, Loder E, Reed M, Lipton RB (2006) Patterns of diagnosis and acute and preventive treatment for migraine in the United States: results from the American Migraine Prevalence and Prevention study. Headache J Head Face Pain 47(3):355–363
2.
go back to reference Cady RK (1999) Diagnosis and treatment of migraine. Clin Cornerstone 1(6):21–32, 10682185, 10.1016/S1098-3597(99)90037-6, 1:STN:280:DC%2BD3c7ks1OltA%3D%3DCrossRefPubMed Cady RK (1999) Diagnosis and treatment of migraine. Clin Cornerstone 1(6):21–32, 10682185, 10.1016/S1098-3597(99)90037-6, 1:STN:280:DC%2BD3c7ks1OltA%3D%3DCrossRefPubMed
3.
go back to reference Bigal ME, Lipton RB, Stewart WF (2004) The epidemiology and impact of migraine. Curr Neurol Neurosci Rep 4(2):98–104, 14984680, 10.1007/s11910-004-0022-8CrossRefPubMed Bigal ME, Lipton RB, Stewart WF (2004) The epidemiology and impact of migraine. Curr Neurol Neurosci Rep 4(2):98–104, 14984680, 10.1007/s11910-004-0022-8CrossRefPubMed
4.
go back to reference Bigal ME, Lipton RB, Holland PR, Goadsby PJ (2007) Obesity, migraine, and chronic migraine: possible mechanisms of interaction. Neurology 68(21):1851–1861, 17515549, 10.1212/01.wnl.0000262045.11646.b1CrossRefPubMed Bigal ME, Lipton RB, Holland PR, Goadsby PJ (2007) Obesity, migraine, and chronic migraine: possible mechanisms of interaction. Neurology 68(21):1851–1861, 17515549, 10.1212/01.wnl.0000262045.11646.b1CrossRefPubMed
5.
go back to reference Kurth T (2007) Associations between migraine and cardiovascular disease. Expert Rev Neurother 7(9):1097–1104, 17868009, 10.1586/14737175.7.9.1097CrossRefPubMed Kurth T (2007) Associations between migraine and cardiovascular disease. Expert Rev Neurother 7(9):1097–1104, 17868009, 10.1586/14737175.7.9.1097CrossRefPubMed
6.
go back to reference Sevillano-Garcia MD, Manso-Calderon R, Cacabelos-Perez P (2007) Comorbidity in the migraine: depression, anxiety, stress and insomnia. Rev Neurol 45(7):400–405, 17918105, 1:STN:280:DC%2BD2srpsFyrtA%3D%3DPubMed Sevillano-Garcia MD, Manso-Calderon R, Cacabelos-Perez P (2007) Comorbidity in the migraine: depression, anxiety, stress and insomnia. Rev Neurol 45(7):400–405, 17918105, 1:STN:280:DC%2BD2srpsFyrtA%3D%3DPubMed
7.
go back to reference Merikangas KR, Fenton BT, Cheng SH, Stolar MJ, Risch N (1997) Association between migraine and stroke in a large-scale epidemiological study of the United States. Arch Neurol 54(4):362–368, 9109736, 1:STN:280:DyaK2s3mtlyltg%3D%3DCrossRefPubMed Merikangas KR, Fenton BT, Cheng SH, Stolar MJ, Risch N (1997) Association between migraine and stroke in a large-scale epidemiological study of the United States. Arch Neurol 54(4):362–368, 9109736, 1:STN:280:DyaK2s3mtlyltg%3D%3DCrossRefPubMed
9.
go back to reference Merikangas KR, Fenton BT (1994) Comorbidity of migraine with somatic disorders in a large-scale epidemiologic study in the United States (47):301–314 Merikangas KR, Fenton BT (1994) Comorbidity of migraine with somatic disorders in a large-scale epidemiologic study in the United States (47):301–314
10.
go back to reference Aamodt AH, Stovner LJ, Hagen K, Zwart JA (2008) Comorbidity of headache and gastrointestinal complaints. The Head-HUNT Study. Cephalalgia 28(2):144–151, 18197884, 1:STN:280:DC%2BD1c%2FksVaqtQ%3D%3DPubMed Aamodt AH, Stovner LJ, Hagen K, Zwart JA (2008) Comorbidity of headache and gastrointestinal complaints. The Head-HUNT Study. Cephalalgia 28(2):144–151, 18197884, 1:STN:280:DC%2BD1c%2FksVaqtQ%3D%3DPubMed
11.
go back to reference Featherstone HJ (1985) Medical diagnoses and problems in individuals with recurrent idiopathic headaches. Headache 25(3):136–140, 10.1111/j.1526-4610.1985.hed2503136.x, 1:STN:280:DyaL2M3jtlylsg%3D%3DCrossRef Featherstone HJ (1985) Medical diagnoses and problems in individuals with recurrent idiopathic headaches. Headache 25(3):136–140, 10.1111/j.1526-4610.1985.hed2503136.x, 1:STN:280:DyaL2M3jtlylsg%3D%3DCrossRef
12.
go back to reference Locke GR III, Talley NJ, Fett SL, Zinsmeister AR, Melton LJ III (1997) Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology 112(5):1448–1456, 9136821, 10.1016/S0016-5085(97)70025-8CrossRefPubMed Locke GR III, Talley NJ, Fett SL, Zinsmeister AR, Melton LJ III (1997) Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology 112(5):1448–1456, 9136821, 10.1016/S0016-5085(97)70025-8CrossRefPubMed
13.
go back to reference Gutthann SP, Guez LA, Raiford DS (1997) Individual nonsteroidal antiinflammatory drugs and other risk factors for upper gastrointestinal bleeding and perforation. Epidemiology 8(1):18–24, 9116088, 10.1097/00001648-199701000-00003, 1:STN:280:DyaK2s7jtVKnug%3D%3DCrossRefPubMed Gutthann SP, Guez LA, Raiford DS (1997) Individual nonsteroidal antiinflammatory drugs and other risk factors for upper gastrointestinal bleeding and perforation. Epidemiology 8(1):18–24, 9116088, 10.1097/00001648-199701000-00003, 1:STN:280:DyaK2s7jtVKnug%3D%3DCrossRefPubMed
14.
go back to reference Ng-Mak DS, Hu XH, Chen YT, Ma L (2008) Acute migraine treatment with oral triptans and NSAIDS in a managed care population. Headache 48(8):1176–1185, 18819177, 10.1111/j.1526-4610.2007.01055.xCrossRefPubMed Ng-Mak DS, Hu XH, Chen YT, Ma L (2008) Acute migraine treatment with oral triptans and NSAIDS in a managed care population. Headache 48(8):1176–1185, 18819177, 10.1111/j.1526-4610.2007.01055.xCrossRefPubMed
15.
go back to reference Kotzan J, Wade W, Yu HH (2001) Assessing NSAID prescription use as a predisposing factor for gastroesophageal reflux disease in a Medicaid population. Pharm Res 18(9):1367–1372, 11683254, 10.1023/A:1013010616496, 1:CAS:528:DC%2BD3MXnvVehurc%3DCrossRefPubMed Kotzan J, Wade W, Yu HH (2001) Assessing NSAID prescription use as a predisposing factor for gastroesophageal reflux disease in a Medicaid population. Pharm Res 18(9):1367–1372, 11683254, 10.1023/A:1013010616496, 1:CAS:528:DC%2BD3MXnvVehurc%3DCrossRefPubMed
16.
go back to reference Thomas J, Straus WL, Bloom BS (2002) Over-the-counter nonsteroidal anti-inflammatory drugs and risk of gastrointestinal symptoms. Am J Gastroenterol 97(9):2215–2219, 12358235, 10.1111/j.1572-0241.2002.05974.x, 1:CAS:528:DC%2BD38XotV2lu7s%3DCrossRefPubMed Thomas J, Straus WL, Bloom BS (2002) Over-the-counter nonsteroidal anti-inflammatory drugs and risk of gastrointestinal symptoms. Am J Gastroenterol 97(9):2215–2219, 12358235, 10.1111/j.1572-0241.2002.05974.x, 1:CAS:528:DC%2BD38XotV2lu7s%3DCrossRefPubMed
17.
go back to reference Hsu JC (2007) Hochberg’s step-up method: cutting corners off Holm’s step-down method. Biometrika 94(4):965–975, 10.1093/biomet/asm067CrossRef Hsu JC (2007) Hochberg’s step-up method: cutting corners off Holm’s step-down method. Biometrika 94(4):965–975, 10.1093/biomet/asm067CrossRef
18.
go back to reference Dent J, El Serag HB, Wallander MA, Johansson S (2005) Epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut J Br Soc Gastroenterol 54(5):710–717, 1:STN:280:DC%2BD2M7pslylsA%3D%3D Dent J, El Serag HB, Wallander MA, Johansson S (2005) Epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut J Br Soc Gastroenterol 54(5):710–717, 1:STN:280:DC%2BD2M7pslylsA%3D%3D
19.
go back to reference Shaheen N, Provenzale D (2003) The epidemiology of gastroesophageal reflux disease. Am J Med Sci 326(5):264–273, 14615667, 10.1097/00000441-200311000-00002CrossRefPubMed Shaheen N, Provenzale D (2003) The epidemiology of gastroesophageal reflux disease. Am J Med Sci 326(5):264–273, 14615667, 10.1097/00000441-200311000-00002CrossRefPubMed
20.
go back to reference DiBaise JK, Olusola BF, Huerter JV, Quigley EM (2002) Role of GERD in chronic resistant sinusitis: a prospective, open label, pilot trial. Am J Gastroenterol 97(4):843–850, 12003417, 10.1111/j.1572-0241.2002.05598.xCrossRefPubMed DiBaise JK, Olusola BF, Huerter JV, Quigley EM (2002) Role of GERD in chronic resistant sinusitis: a prospective, open label, pilot trial. Am J Gastroenterol 97(4):843–850, 12003417, 10.1111/j.1572-0241.2002.05598.xCrossRefPubMed
21.
go back to reference Pucci E, Di Stefano M, Miceli E, Corazza GR, Sandrini G, Nappi G (2005) Patients with headache and functional dyspepsia present meal-induced hypersensitivity of the stomach. J Headache Pain 6(4):223–226, 16362670, 10.1007/s10194-005-0191-0PubMedCentralCrossRefPubMed Pucci E, Di Stefano M, Miceli E, Corazza GR, Sandrini G, Nappi G (2005) Patients with headache and functional dyspepsia present meal-induced hypersensitivity of the stomach. J Headache Pain 6(4):223–226, 16362670, 10.1007/s10194-005-0191-0PubMedCentralCrossRefPubMed
22.
go back to reference Spierings EL (2002) Reflux-triggered migraine headache originating from the upper gum/teeth. Cephalalgia 22(7):555–556, 12230598, 10.1046/j.1468-2982.2002.00373.x, 1:STN:280:DC%2BD38vovFektw%3D%3DCrossRefPubMed Spierings EL (2002) Reflux-triggered migraine headache originating from the upper gum/teeth. Cephalalgia 22(7):555–556, 12230598, 10.1046/j.1468-2982.2002.00373.x, 1:STN:280:DC%2BD38vovFektw%3D%3DCrossRefPubMed
23.
go back to reference Peroutka SJ (2004) Migraine: a chronic sympathetic nervous system disorder. Headache J Head Face Pain 44(1):53–64, 10.1111/j.1526-4610.2004.04011.xCrossRef Peroutka SJ (2004) Migraine: a chronic sympathetic nervous system disorder. Headache J Head Face Pain 44(1):53–64, 10.1111/j.1526-4610.2004.04011.xCrossRef
24.
go back to reference Karamanolis G, Sifrim D (2007) Developments in pathogenesis and diagnosis of gastroesophageal reflux disease. Curr Opin Gastroenterol 23(4):428–433, 17545781, 10.1097/MOG.0b013e328133f56aCrossRefPubMed Karamanolis G, Sifrim D (2007) Developments in pathogenesis and diagnosis of gastroesophageal reflux disease. Curr Opin Gastroenterol 23(4):428–433, 17545781, 10.1097/MOG.0b013e328133f56aCrossRefPubMed
25.
go back to reference Moskowitz MA (1990) Basic mechanisms in vascular headache. Neurol Clin 8(4):801–815, 2175382, 1:STN:280:DyaK3M%2FotVOqsQ%3D%3DPubMed Moskowitz MA (1990) Basic mechanisms in vascular headache. Neurol Clin 8(4):801–815, 2175382, 1:STN:280:DyaK3M%2FotVOqsQ%3D%3DPubMed
26.
go back to reference Kurth T, Holtmann G, Neufang-Hnber J, Gerken G, Diener HC (2006) Prevalence of unexplained upper abdominal symptoms in patients with migraine. Cephalalgia 26(5):506–510, 16674758, 10.1111/j.1468-2982.2005.01076.x, 1:STN:280:DC%2BD283ltVCltw%3D%3DCrossRefPubMed Kurth T, Holtmann G, Neufang-Hnber J, Gerken G, Diener HC (2006) Prevalence of unexplained upper abdominal symptoms in patients with migraine. Cephalalgia 26(5):506–510, 16674758, 10.1111/j.1468-2982.2005.01076.x, 1:STN:280:DC%2BD283ltVCltw%3D%3DCrossRefPubMed
27.
go back to reference Edvinsson L (2005) Clinical data on the CGRP antagonist BIBN4096BS for treatment of migraine attacks. Cns Drug Rev 11(1):69–76, 15867953, 1:CAS:528:DC%2BD2MXks1Wls7w%3DCrossRefPubMed Edvinsson L (2005) Clinical data on the CGRP antagonist BIBN4096BS for treatment of migraine attacks. Cns Drug Rev 11(1):69–76, 15867953, 1:CAS:528:DC%2BD2MXks1Wls7w%3DCrossRefPubMed
28.
go back to reference Arakawa T, Uno H, Fukuda T, Higuchi K, Kobayashi K, Kuroki T (1997) New aspects of gastric adaptive relaxation, reflex after food intake for more food: involvement of capsaicin-sensitive sensory nerves and nitric oxide. J Smooth Muscle Res 33(3):81–88, 9533819, 1:CAS:528:DyaK1cXktVSrtLw%3DCrossRefPubMed Arakawa T, Uno H, Fukuda T, Higuchi K, Kobayashi K, Kuroki T (1997) New aspects of gastric adaptive relaxation, reflex after food intake for more food: involvement of capsaicin-sensitive sensory nerves and nitric oxide. J Smooth Muscle Res 33(3):81–88, 9533819, 1:CAS:528:DyaK1cXktVSrtLw%3DCrossRefPubMed
29.
go back to reference Meucci G, Radaelli F, Prada A, Bortoli A, Crotta S, Cerrato C, Minoli G (2005) Increased prevalence of migraine in patients with uninvestigated dyspepsia referred for open-access upper gastrointestinal endoscopy. Endoscopy 37(7):622–625, 16010605, 10.1055/s-2005-870251, 1:STN:280:DC%2BD2MzlsFKmsw%3D%3DCrossRefPubMed Meucci G, Radaelli F, Prada A, Bortoli A, Crotta S, Cerrato C, Minoli G (2005) Increased prevalence of migraine in patients with uninvestigated dyspepsia referred for open-access upper gastrointestinal endoscopy. Endoscopy 37(7):622–625, 16010605, 10.1055/s-2005-870251, 1:STN:280:DC%2BD2MzlsFKmsw%3D%3DCrossRefPubMed
30.
go back to reference Horowitz M, Su YC, Rayner CK, Jones KL (2001) Gastroparesis: prevalence, clinical significance and treatment. Can J Gastroenterol 15(12):805–813, 11773947, 1:STN:280:DC%2BD38%2FltVGlsw%3D%3DPubMed Horowitz M, Su YC, Rayner CK, Jones KL (2001) Gastroparesis: prevalence, clinical significance and treatment. Can J Gastroenterol 15(12):805–813, 11773947, 1:STN:280:DC%2BD38%2FltVGlsw%3D%3DPubMed
31.
go back to reference Aurora SK, Kori SH, Barrodale P, McDonald SA, Haseley D (2006) Gastric stasis in migraine: more than just a paroxysmal abnormality during a migraine attack. Headache J Head Face Pain 46(1):57–63, 10.1111/j.1526-4610.2006.00311.xCrossRef Aurora SK, Kori SH, Barrodale P, McDonald SA, Haseley D (2006) Gastric stasis in migraine: more than just a paroxysmal abnormality during a migraine attack. Headache J Head Face Pain 46(1):57–63, 10.1111/j.1526-4610.2006.00311.xCrossRef
32.
go back to reference Talley NJ, Zinsmeister AR, Schleck CD, Melton LJ III (1992) Dyspepsia and dyspepsia subgroups: a population-based study. Gastroenterology 102(4 Pt 1):1259–1268, 1551533, 1:STN:280:DyaK383gtFGltg%3D%3DPubMed Talley NJ, Zinsmeister AR, Schleck CD, Melton LJ III (1992) Dyspepsia and dyspepsia subgroups: a population-based study. Gastroenterology 102(4 Pt 1):1259–1268, 1551533, 1:STN:280:DyaK383gtFGltg%3D%3DPubMed
33.
go back to reference Laine L (2002) The gastrointestinal effects of nonselective NSAIDs and COX-2-selective inhibitors. Semin Arthritis Rheum 32(3):25–32, 12528071, 10.1053/sarh.2002.37217, 1:CAS:528:DC%2BD3sXot1Sjug%3D%3DCrossRefPubMed Laine L (2002) The gastrointestinal effects of nonselective NSAIDs and COX-2-selective inhibitors. Semin Arthritis Rheum 32(3):25–32, 12528071, 10.1053/sarh.2002.37217, 1:CAS:528:DC%2BD3sXot1Sjug%3D%3DCrossRefPubMed
34.
go back to reference Voutilainen M, Sipponen P, Mecklin JP, Juhola M (2000) Gastroesophageal reflux disease: prevalence, clinical, endoscopic and histopathological findings in 1, 128 consecutive patients referred for endoscopy due to dyspeptic and reflux symptoms. Digestion 61(1):6–13, 10671769, 10.1159/000007730, 1:STN:280:DC%2BD3c7jsl2ksg%3D%3DCrossRefPubMed Voutilainen M, Sipponen P, Mecklin JP, Juhola M (2000) Gastroesophageal reflux disease: prevalence, clinical, endoscopic and histopathological findings in 1, 128 consecutive patients referred for endoscopy due to dyspeptic and reflux symptoms. Digestion 61(1):6–13, 10671769, 10.1159/000007730, 1:STN:280:DC%2BD3c7jsl2ksg%3D%3DCrossRefPubMed
35.
go back to reference Bigard MA, Pelletier AL (2004) Esophageal complications of non steroidal antiinflammatory drugs. Gastroenterol Clin Biol 28:358–361, 10.1016/S0399-8320(04)95279-7CrossRef Bigard MA, Pelletier AL (2004) Esophageal complications of non steroidal antiinflammatory drugs. Gastroenterol Clin Biol 28:358–361, 10.1016/S0399-8320(04)95279-7CrossRef
36.
go back to reference Kim SL, Hunter JG, Wo JM, Davis LP, Waring JP (1999) NSAIDs, aspirin, and esophageal strictures: are over-the-counter medications harmful to the esophagus? J Clin Gastroenterol 29(1):32–34, 10405227, 10.1097/00004836-199907000-00008, 1:STN:280:DyaK1Mzjt1Wgug%3D%3DCrossRefPubMed Kim SL, Hunter JG, Wo JM, Davis LP, Waring JP (1999) NSAIDs, aspirin, and esophageal strictures: are over-the-counter medications harmful to the esophagus? J Clin Gastroenterol 29(1):32–34, 10405227, 10.1097/00004836-199907000-00008, 1:STN:280:DyaK1Mzjt1Wgug%3D%3DCrossRefPubMed
37.
go back to reference Dodick DW, Martin VT, Smith T, Silberstein S (2004) Cardiovascular tolerability and safety of triptans: a review of clinical data. Headache 44(s1):S20–S30 Dodick DW, Martin VT, Smith T, Silberstein S (2004) Cardiovascular tolerability and safety of triptans: a review of clinical data. Headache 44(s1):S20–S30
38.
go back to reference Mulleners WM, Aurora SK, Chronicle EP, Stewart R, Gopal S, Koehler PJ (2001) Self-reported photophobic symptoms in migraineurs and controls are reliable and predict diagnostic category accurately. Headache J Head Face Pain 41(1):31–39, 10.1046/j.1526-4610.2001.111006031.x, 1:STN:280:DC%2BD3Mzit1WisA%3D%3DCrossRef Mulleners WM, Aurora SK, Chronicle EP, Stewart R, Gopal S, Koehler PJ (2001) Self-reported photophobic symptoms in migraineurs and controls are reliable and predict diagnostic category accurately. Headache J Head Face Pain 41(1):31–39, 10.1046/j.1526-4610.2001.111006031.x, 1:STN:280:DC%2BD3Mzit1WisA%3D%3DCrossRef
39.
go back to reference Iversen L, Hannaford PC, Godden DJ, Price D (2007) Do people self-reporting information about chronic respiratory disease have corroborative evidence in their general practice medical records? A study of intermethod reliability. Prim Care Resp J 16(3):162–168, 10.3132/pcrj.2007.00013 Iversen L, Hannaford PC, Godden DJ, Price D (2007) Do people self-reporting information about chronic respiratory disease have corroborative evidence in their general practice medical records? A study of intermethod reliability. Prim Care Resp J 16(3):162–168, 10.3132/pcrj.2007.00013
40.
go back to reference Tseeng S, Arora R (2008) Aspirin resistance: biological and clinical implications. J Cardiovasc Pharmacol Ther 13(1):5–12, 18287586, 10.1177/1074248407310869, 1:CAS:528:DC%2BD1cXjtVOhs7w%3DCrossRefPubMed Tseeng S, Arora R (2008) Aspirin resistance: biological and clinical implications. J Cardiovasc Pharmacol Ther 13(1):5–12, 18287586, 10.1177/1074248407310869, 1:CAS:528:DC%2BD1cXjtVOhs7w%3DCrossRefPubMed
41.
go back to reference Ducrotte P, Liker HR (2007) How do people with gastro-oesophageal reflux disease perceive their disease? Results of a multinational survey. Curr Med Res Opin 23(11):2857–2865, 17919358, 10.1185/030079907X233412CrossRefPubMed Ducrotte P, Liker HR (2007) How do people with gastro-oesophageal reflux disease perceive their disease? Results of a multinational survey. Curr Med Res Opin 23(11):2857–2865, 17919358, 10.1185/030079907X233412CrossRefPubMed
42.
go back to reference Malik SN, Hopkins M, Young WB, Silberstein SD (2006) Acute migraine treatment: patterns of use and satisfaction in a clinical population. Headache J Head Face Pain 46(5):773–780, 10.1111/j.1526-4610.2006.00437.xCrossRef Malik SN, Hopkins M, Young WB, Silberstein SD (2006) Acute migraine treatment: patterns of use and satisfaction in a clinical population. Headache J Head Face Pain 46(5):773–780, 10.1111/j.1526-4610.2006.00437.xCrossRef
43.
go back to reference Holmes WF, MacGregor EA, Sawyer JP, Lipton RB (2001) Information about migraine disability influences physicians’ perceptions of illness severity and treatment needs. Headache J Head Face Pain 41(4):343–350, 10.1046/j.1526-4610.2001.111006343.x, 1:STN:280:DC%2BD3M3jtFSjsw%3D%3DCrossRef Holmes WF, MacGregor EA, Sawyer JP, Lipton RB (2001) Information about migraine disability influences physicians’ perceptions of illness severity and treatment needs. Headache J Head Face Pain 41(4):343–350, 10.1046/j.1526-4610.2001.111006343.x, 1:STN:280:DC%2BD3M3jtFSjsw%3D%3DCrossRef
Metadata
Title
GERD prevalence in migraine patients and the implication for acute migraine treatment
Authors
Božena J. Katić
Wendy Golden
Roger K. Cady
X. Henry Hu
Publication date
01-02-2009
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 1/2009
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1007/s10194-008-0083-1

Other articles of this Issue 1/2009

The Journal of Headache and Pain 1/2009 Go to the issue