Top

Journal of the Association for Research in Otolaryngology

Published in:

01-03-2010

The Effect of Contralateral Acoustic Stimulation on Spontaneous Otoacoustic Emissions

Authors: Wei Zhao, Sumitrajit Dhar

Published in: Journal of the Association for Research in Otolaryngology | Issue 1/2010

Abstract

Evoked otoacoustic emissions are often used to study the medial olivocochlear (MOC) efferents in humans. There has been concern that the emission-evoking stimulus may itself elicit efferent activity and alter the evoked otoacoustic emission. Spontaneous otoacoustic emissions (SOAEs) are hence advantageous as no external stimulation is necessary to record the response in the test ear. Contralateral acoustic stimulation (CAS) has been shown to suppress SOAE level and elevate SOAE frequency, but the time course of these effects is largely unknown. By utilizing the Choi–Williams distribution, here we report a gradual adaptation during the presence of CAS and an overshoot following CAS offset in both SOAE magnitude and frequency from six normal-hearing female human subjects. Furthermore, we have quantified the time constants of both magnitude and frequency shifts at the onset, presence, and offset of four levels of CAS. Most studies using contralateral elicitors do not stringently control the middle-ear muscle (MEM) reflex, leaving the results difficult to interpret. In addition to clinically available measures of the MEM reflex, we have incorporated a sensitive laboratory technique to monitor the MEM reflex in our subjects, allowing us to interpret the results with greater confidence.

Backus BC, Guinan JJ Jr (2006) Time-course of the human medial olivocochlear reflex. J. Acoust. Soc. Am. 119:2889–2904CrossRefPubMed

Bassim MK, Miller RL, Buss E, Smith DW (2003) Rapid adaptation of the 2f1–f2 DPOAE in humans: binaural and contralateral stimulation effects. Hear Res 182:140–152CrossRefPubMed

Brown MC (1989) Morphology and response properties of single olivocochlear fibers in the guinea pig. Hear. Res. 40:93–109CrossRefPubMed

Burns EM, Harrison WA, Bulen JC, Keefe DH (1993) Voluntary contraction of middle ear muscles: effects on input impedance, energy reflectance and spontaneous otoacoustic emissions. Hear. Res. 67:117–127CrossRefPubMed

Cohen L (1995) Time–frequency analysis. Prentice Hall, Englewood Cliffs

Collet L, Kemp DT, Veuillet E, Duclaux R, Moulin A, Morgon A (1990) Effect of contralateral auditory stimuli on active cochlear micro-mechanical properties in human subjects. Hear. Res. 43:251–261CrossRefPubMed

Cooper NP, Guinan JJ Jr (2003) Separate mechanical processes underlie fast and slow effects of medial olivocochlear efferent activity. J. Physiol. 548:307–312CrossRefPubMed

Dallos P (1992) The active cochlea. J. Neurosci. 12:4575–4585PubMed

Dolan DF, Guo MH, Nuttall AL (1997) Frequency-dependent enhancement of basilar membrane velocity during olivocochlear bundle stimulation. J. Acoust. Soc. Am. 102:3587–3596CrossRefPubMed

Elgoyhen AB, Johnson DS, Boulter J, Vetter DE, Heinemann S (1994) Alpha 9: an acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells. Cell 79:705–715CrossRefPubMed

Elgoyhen AB, Vetter DE, Katz E, Rothlin CV, Heinemann SF, Boulter J (2001) Alpha10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells. Proc. Natl. Acad. Sci. USA 98:3501–3506CrossRefPubMed

Erostegui C, Norris CH, Bobbin RP (1994) In vitro pharmacologic characterization of a cholinergic receptor on outer hair cells. Hear. Res. 74:135–147CrossRefPubMed

Evans MG (1996) Acetylcholine activates two currents in guinea-pig outer hair cells. J. Physiol. 491(Pt 2):563–578PubMed

Eybalin M (1993) Neurotransmitters and neuromodulators of the mammalian cochlea. Physiol. Rev. 73:309–373PubMed

Feeney MP, Keefe DH, Marryott LP (2003) Contralateral acoustic reflex thresholds for tonal activators using wideband energy reflectance and admittance. J. Speech. Lang. Hear. Res. 46:128–136CrossRefPubMed

Fex J (1962) Auditory activity in centrifugal and centripetal cochlear fibres in cat. A study of a feedback system. Acta. Physiol. Scand. Suppl. 189:1–68

Fuchs PA, Murrow BW (1992) Cholinergic inhibition of short (outer) hair cells of the chick’s cochlea. J. Neurosci. 12:800–809PubMed

Galambos R (1956) Suppression of auditory nerve activity by stimulation of efferent fibers to cochlea. J. Neurophysiol. 19:424–437PubMed

Garinis AC, Glattke T, Cone-Wesson BK (2008) TEOAE suppression in adults with learning disabilities. Int. J. Audiol. 47:607–614CrossRefPubMed

Gelfand SA (1984) The contralateral acoustic reflex. In: Silman S (ed) The acoustic reflex: basic principles and clinical applications. Academic, Orlando, pp 137–186

Gifford ML, Guinan JJ Jr (1987) Effects of electrical stimulation of medial olivocochlear neurons on ipsilateral and contralateral cochlear responses. Hear. Res. 29:179–194CrossRefPubMed

Giraud AL, Collet L, Chery-Croze S, Magnan J, Chays A (1995) Evidence of a medial olivocochlear involvement in contralateral suppression of otoacoustic emissions in humans. Brain. Res. 705:15–23CrossRefPubMed

Goodman SS, Keefe DH (2006) Simultaneous measurement of noise-activated middle-ear muscle reflex and stimulus frequency otoacoustic emissions. J. Assoc. Res. Otolaryngol. 7:125–139CrossRefPubMed

Guinan JJ Jr (2006) Olivocochlear efferents: anatomy, physiology, function, and the measurement of efferent effects in humans. Ear. Hear. 27:589–607CrossRefPubMed

Guinan JJ Jr, Backus BC, Lilaonitkul W, Aharonson V (2003) Medial olivocochlear efferent reflex in humans: otoacoustic emission (OAE) measurement issues and the advantages of stimulus frequency OAEs. J. Assoc. Res. Otolaryngol. 4:521–540CrossRefPubMed

Harrison WA, Burns EM (1993) Effects of contralateral acoustic stimulation on spontaneous otoacoustic emissions. J. Acoust. Soc. Am. 94:2649–2658CrossRefPubMed

Hirsh IJ, Ward WD (1952) Recovery of the auditory threshold after strong acoustic stimulation. J. Acoust. Soc. Am. 24:131–141CrossRef

Hood LJ, Berlin CI, Bordelon J, Rose K (2003) Patients with auditory neuropathy/dys-synchrony lack efferent suppression of transient evoked otoacoustic emissions. J. Am. Acad. Audiol. 14:302–313PubMed

Housley GD, Ashmore JF (1991) Direct measurement of the action of acetylcholine on isolated outer hair cells of the guinea pig cochlea. Proc. Biol. Sci. 244:161–167CrossRefPubMed

Kakehata S, Nakagawa T, Takasaka T, Akaike N (1993) Cellular mechanism of acetylcholine-induced response in dissociated outer hair cells of guinea-pig cochlea. J. Physiol. 463:227–244PubMed

Kemp DT (1986) Otoacoustic emissions, travelling waves and cochlear mechanisms. Hear. Res. 22:95–104CrossRefPubMed

Kevanishvili Z, Hofmann G, Burdzgla I, Pietsch M, Gamgebeli Z, Yarin Y, Tushishvili M, Zahnert T (2006) Behavior of evoked otoacoustic emission under low-frequency tone exposure: objective study of the bounce phenomenon in humans. Hear. Res. 222:62–69CrossRefPubMed

Kim DO, Dorn PA, Neely ST, Gorga MP (2001) Adaptation of distortion product otoacoustic emission in humans. J. Assoc. Res. Otolaryngol. 2:31–40PubMed

Kirk DL, Patuzzi RB (1997) Transient changes in cochlear potentials and DPOAEs after low-frequency tones: the ‘two-minute bounce’ revisited. Hear. Res. 112:49–68CrossRefPubMed

Kirk DL, Moleirinho A, Patuzzi RB (1997) Microphonic and DPOAE measurements suggest a micromechanical mechanism for the ‘bounce’ phenomenon following low-frequency tones. Hear. Res. 112:69–86CrossRefPubMed

Kujawa SG, Liberman MC (2001) Effects of olivocochlear feedback on distortion product otoacoustic emissions in guinea pig. J. Assoc. Res. Otolaryngol. 2:268–278PubMed

Liberman MC (1989) Rapid assessment of sound-evoked olivocochlear feedback: suppression of compound action potentials by contralateral sound. Hear. Res. 38:47–56CrossRefPubMed

Liberman MC, Brown MC (1986) Physiology and anatomy of single olivocochlear neurons in the cat. Hear. Res. 24:17–36CrossRefPubMed

Liberman MC, Puria S, Guinan JJ Jr (1996) The ipsilaterally evoked olivocochlear reflex causes rapid adaptation of the 2f1-f2 distortion product otoacoustic emission. J. Acoust. Soc. Am. 99:3572–3584CrossRefPubMed

Lilaonitkul W, Guinan JJ Jr (2009) Human Medial Olivocochlear Reflex: Effects as Functions of Contralateral, Ipsilateral, and Bilateral Elicitor Bandwidths. J Assoc Res Otolaryngol 10:459–470CrossRefPubMed

Long GR, Talmadge CL (1997) Spontaneous otoacoustic emission frequency is modulated by heartbeat. J. Acoust. Soc. Am. 102:2831–2848CrossRefPubMed

Maison S, Micheyl C, Andeol G, Gallego S, Collet L (2000) Activation of medial olivocochlear efferent system in humans: influence of stimulus bandwidth. Hear. Res. 140:111–125CrossRefPubMed

Maison SF, Adams JC, Liberman MC (2003) Olivocochlear innervation in the mouse: immunocytochemical maps, crossed versus uncrossed contributions, and transmitter colocalization. J. Comp. Neurol. 455:406–416CrossRefPubMed

Mott JB, Norton SJ, Neely ST, Warr WB (1989) Changes in spontaneous otoacoustic emissions produced by acoustic stimulation of the contralateral ear. Hear. Res. 38:229–242CrossRefPubMed

Moulin A, Collet L, Duclaux R (1993a) Contralateral auditory stimulation alters acoustic distortion products in humans. Hear Res 65:193–210CrossRefPubMed

Moulin A, Collet L, Duclaux R (1993b) Contralateral auditory stimulation alters acoustic distortion products in humans. Hear. Res. 65:193–210CrossRef

Mountain DC (1980) Changes in endolymphatic potential and crossed olivocochlear bundle stimulation alter cochlear mechanics. Science 210:71–72CrossRefPubMed

Muller-Wehlau M, Mauermann M, Dau T, Kollmeier B (2005) The effects of neural synchronization and peripheral compression on the acoustic-reflex threshold. J. Acoust. Soc. Am. 117:3016–3027CrossRefPubMed

Murphy WJ, Tubis A, Talmadge CL, Long GR (1995) Relaxation dynamics of spontaneous otoacoustic emissions perturbed by external tones. II. Suppression of interacting emissions. J. Acoust. Soc. Am. 97:3711–3720CrossRefPubMed

Murugasu E, Russell IJ (1996) The effect of efferent stimulation on basilar membrane displacement in the basal turn of the guinea pig cochlea. J. Neurosci. 16:325–332PubMed

Neumann J, Uppenkamp S, Kollmeier B (1996) Detection of the acoustic reflex below 80 dB HL. Audiol. Neurootol. 1:359–369CrossRefPubMed

Norman M, Thornton AR (1993) Frequency analysis of the contralateral suppression of evoked otoacoustic emissions by narrow-band noise. Br. J. Audiol. 27:281–289CrossRefPubMed

Oliver D, Klocker N, Schuck J, Baukrowitz T, Ruppersberg JP, Fakler B (2000) Gating of Ca²⁺-activated K⁺ channels controls fast inhibitory synaptic transmission at auditory outer hair cells. Neuron 26:595–601CrossRefPubMed

Relkin EM, Sterns A, Azeredo W, Prieve BA, Woods CI (2005) Physiological mechanisms of onset adaptation and contralateral suppression of DPOAEs in the rat. J. Assoc. Res. Otolaryngol. 6:119–135CrossRefPubMed

Robertson D, Gummer M (1985) Physiological and morphological characterization of efferent neurones in the guinea pig cochlea. Hear. Res. 20:63–77CrossRefPubMed

Robles L, Delano PH (2008) Efferent system. In: Dallos P, Oertel D (eds) The senses: a comprehensive reference. Academic, New York

Shera CA (2003) Mammalian spontaneous otoacoustic emissions are amplitude-stabilized cochlear standing waves. J. Acoust. Soc. Am. 114:244–262CrossRefPubMed

Siegel JH, Kim DO (1982) Efferent neural control of cochlear mechanics? Olivocochlear bundle stimulation affects cochlear biomechanical nonlinearity. Hear. Res. 6:171–182CrossRefPubMed

Smurzynski J, Lisowska G, Grzanka A, Namysloski G 2002. Dynamic changes in spontaneous otoacoustic emissions produced by contralateral broadband noise. Biophysics of the Cochlea, Proc Int Symp, Titisee, Germany

Sridhar TS, Liberman MC, Brown MC, Sewell WF (1995) A novel cholinergic "slow effect" of efferent stimulation on cochlear potentials in the guinea pig. J. Neurosci. 15:3667–3678PubMed

Sun XM (2008a) Contralateral suppression of distortion product otoacoustic emissions and the middle-ear muscle reflex in human ears. Hear. Res. 237:66–75CrossRef

Sun XM (2008b) Distortion product otoacoustic emission fine structure is responsible for variability of distortion product otoacoustic emission contralateral suppression. J. Acoust. Soc. Am. 123:4310–4320CrossRef

Velenovsky DS, Glattke TJ (2002) The effect of noise bandwidth on the contralateral suppression of transient evoked otoacoustic emissions. Hear. Res. 164:39–48CrossRefPubMed

Veuillet E, Collet L, Duclaux R (1991) Effect of contralateral acoustic stimulation on active cochlear micromechanical properties in human subjects: dependence on stimulus variables. J. Neurophysiol. 65:724–735PubMed

Whitehead ML, Martin GK, Lonsbury-Martin BL (1991) Effects of the crossed acoustic reflex on distortion-product otoacoustic emissions in awake rabbits. Hear. Res. 51:55–72CrossRefPubMed

Wiederhold ML, Kiang NY (1970) Effects of electric stimulation of the crossed olivocochlear bundle on single auditory-nerve fibers in the cat. J. Acoust. Soc. Am. 48:950–965CrossRefPubMed

Williams DM, Brown AM (1997) The effect of contralateral broad-band noise on acoustic distortion products from the human ear. Hear. Res. 104:127–146CrossRefPubMed

Yoshida N, Liberman MC, Brown MC, Ssewell WF (2001) Fast, but not slow, effects of olivocochlear activation are resistant to apamin. J. Neurophysiol. 85:84–88PubMed

Zucker RS, Regehr WG (2002) Short-term synaptic plasticity. Annu. Rev. Physiol. 64:355–405CrossRefPubMed

Zyl AV, S wanepoel DW, Hall JW 3rd (2009) Effect of prolonged contralateral acoustic stimulation on transient evoked otoacoustic emissions. Hear. Res. 254:77–81CrossRefPubMed

Title: The Effect of Contralateral Acoustic Stimulation on Spontaneous Otoacoustic Emissions
Authors: Wei Zhao
Sumitrajit Dhar
Publication date: 01-03-2010
Publisher: Springer-Verlag
Published in: Journal of the Association for Research in Otolaryngology / Issue 1/2010
Print ISSN: 1525-3961
Electronic ISSN: 1438-7573
DOI: https://doi.org/10.1007/s10162-009-0189-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The Effect of Contralateral Acoustic Stimulation on Spontaneous Otoacoustic Emissions

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2010

Cell-Specific Inducible Gene Recombination in Postnatal Inner Ear Supporting Cells and Glia

Amplitude Modulation and Loudness in Cochlear Implantees

Auditory Cortical Activity During Cochlear Implant-Mediated Perception of Spoken Language, Melody, and Rhythm

Tympanic Membrane Boundary Deformations Derived from Static Displacements Observed with Computerized Tomography in Human and Gerbil

Glycosylation Regulates Prestin Cellular Activity

A Quantitative Analysis of the Spatiotemporal Pattern of Transient Receptor Potential Gene Expression in the Developing Mouse Cochlea