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Clinical and Experimental Nephrology
Published in: Clinical and Experimental Nephrology 11/2023

Open Access 27-07-2023 | Chronic Kidney Disease | Review article

d-Serine as a sensor and effector of the kidney

Authors: Tomonori Kimura, Shinsuke Sakai, Yoshitaka Isaka

Published in: Clinical and Experimental Nephrology | Issue 11/2023

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Abstract

d-Serine, a rare enantiomer of serine, is a biomarker of kidney disease and function. The level of d-serine in the human body is precisely regulated through the urinary clearance of the kidney, and its clearance serves as a new measure of glomerular filtration rate with a lower bias than creatinine clearance. d-Serine also has a direct effect on the kidneys and mediates the cellular proliferation of tubular cells via mTOR signaling and induces kidney remodeling as a compensatory reaction to the loss of kidney mass. In living kidney donors, the removal of the kidney results in an increase in blood d-serine level, which in turn accelerates kidney remodeling and augments kidney clearance, thus reducing blood levels of d-serine. This feedback system strictly controls d-serine levels in the body. The function of d-serine as a biomarker and modulator of kidney function will be the basis of precision medicine for kidney diseases.
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Metadata
Title
d-Serine as a sensor and effector of the kidney
Authors
Tomonori Kimura
Shinsuke Sakai
Yoshitaka Isaka
Publication date
27-07-2023
Publisher
Springer Nature Singapore
Published in
Clinical and Experimental Nephrology / Issue 11/2023
Print ISSN: 1342-1751
Electronic ISSN: 1437-7799
DOI
https://doi.org/10.1007/s10157-023-02384-4

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