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01-02-2018 | Original article

The incidence of the nephrotic syndrome in childhood in Germany

Authors: Ingo Franke, Malik Aydin, Corinna Elke Llamas Lopez, Lisa Kurylowicz, Rainer Ganschow, Michael Lentze, Mark Born

Published in: Clinical and Experimental Nephrology | Issue 1/2018

Abstract

Background

The incidence of childhood nephrotic syndrome (NS) in Germany is not well known.

Methods

An ESPED-based nationwide collection of epidemiological data of children in 2005 and 2006.

Result

The mean age of NS at onset was 5.5 ± 3.7 years. The gender ratio of boys to girls was 1.8:1. The average length of stay was 15.5 ± 11.2 days, with younger children remaining significantly longer in hospital. Steroid-resistance was more common in children ≥8 years (p = 0.023). Focal-segmental glomerulosclerosis (FSGS) was more common in children >10 years (p = 0.029). The ratio of males to females with FSGS was 1:1.9, thus the FSGS risk for girls at onset was 3.3-times greater. Considering the available data, the incidence of NS in Germany is 1.2/100,000 in the population <18 years, of which 1.0/100,000 are steroid-sensitive.

Conclusion

Compared with international data, which primarily focused on regional and small populations, this is the largest study about the incidence of the childhood NS.

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Title: The incidence of the nephrotic syndrome in childhood in Germany
Authors: Ingo Franke
Malik Aydin
Corinna Elke Llamas Lopez
Lisa Kurylowicz
Rainer Ganschow
Michael Lentze
Mark Born
Publication date: 01-02-2018
Publisher: Springer Japan
Published in: Clinical and Experimental Nephrology / Issue 1/2018
Print ISSN: 1342-1751
Electronic ISSN: 1437-7799
DOI: https://doi.org/10.1007/s10157-017-1433-6

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