Skip to main content
Top
Published in: Techniques in Coloproctology 1/2024

Open Access 01-12-2024 | Rectal Cancer | Original Article

Convolutional neural network deep learning model accurately detects rectal cancer in endoanal ultrasounds

Authors: D. Carter, D. Bykhovsky, A. Hasky, I. Mamistvalov, Y. Zimmer, E. Ram, O. Hoffer

Published in: Techniques in Coloproctology | Issue 1/2024

Login to get access

Abstract

Background

Imaging is vital for assessing rectal cancer, with endoanal ultrasound (EAUS) being highly accurate in large tertiary medical centers. However, EAUS accuracy drops outside such settings, possibly due to varied examiner experience and fewer examinations. This underscores the need for an AI-based system to enhance accuracy in non-specialized centers. This study aimed to develop and validate deep learning (DL) models to differentiate rectal cancer in standard EAUS images.

Methods

A transfer learning approach with fine-tuned DL architectures was employed, utilizing a dataset of 294 images. The performance of DL models was assessed through a tenfold cross-validation.

Results

The DL diagnostics model exhibited a sensitivity and accuracy of 0.78 each. In the identification phase, the automatic diagnostic platform achieved an area under the curve performance of 0.85 for diagnosing rectal cancer.

Conclusions

This research demonstrates the potential of DL models in enhancing rectal cancer detection during EAUS, especially in settings with lower examiner experience. The achieved sensitivity and accuracy suggest the viability of incorporating AI support for improved diagnostic outcomes in non-specialized medical centers.
Literature
1.
go back to reference Ahuja NK, Sauer BG, Wang AY, White GE, Zabolotsky A, Koons A, Leung W, Sarkaria S, Kahaleh M, Waxman I et al (2015) Performance of endoscopic ultrasound in staging rectal adenocarcinoma appropriate for primary surgical resection. Clin Gastroenterol Hepatol 13(2):339–344CrossRefPubMed Ahuja NK, Sauer BG, Wang AY, White GE, Zabolotsky A, Koons A, Leung W, Sarkaria S, Kahaleh M, Waxman I et al (2015) Performance of endoscopic ultrasound in staging rectal adenocarcinoma appropriate for primary surgical resection. Clin Gastroenterol Hepatol 13(2):339–344CrossRefPubMed
2.
go back to reference Nuernberg D, Saftoiu A, Barreiros AP, Burmester E, Ivan ET, Clevert D-A, Dietrich CF, Gilja OH, Lorentzen T, Maconi G et al (2019) EFSUMB recommendations for gastrointestinal ultrasound part 3: endorectal, endoanal and perineal ultrasound. Ultrasound Int Open 5(01):34–51CrossRef Nuernberg D, Saftoiu A, Barreiros AP, Burmester E, Ivan ET, Clevert D-A, Dietrich CF, Gilja OH, Lorentzen T, Maconi G et al (2019) EFSUMB recommendations for gastrointestinal ultrasound part 3: endorectal, endoanal and perineal ultrasound. Ultrasound Int Open 5(01):34–51CrossRef
3.
go back to reference Puli SR, Bechtold ML, Reddy JBK, Choudhary A, Antillon MR, Brugge WR (2009) How good is endoscopic ultrasound in differentiating various t stages of rectal cancer? Meta-analysis and systematic review. Ann Surg Oncol 16:254–265CrossRefPubMed Puli SR, Bechtold ML, Reddy JBK, Choudhary A, Antillon MR, Brugge WR (2009) How good is endoscopic ultrasound in differentiating various t stages of rectal cancer? Meta-analysis and systematic review. Ann Surg Oncol 16:254–265CrossRefPubMed
4.
go back to reference Marusch F, Ptok H, Sahm M, Schmidt U, Ridwelski K, Gastinger I, Lippert H (2011) Endorectal ultrasound in rectal carcinoma–do the literature results really correspond to the realities of routine clinical care? Endoscopy 43(05):425–431CrossRefPubMed Marusch F, Ptok H, Sahm M, Schmidt U, Ridwelski K, Gastinger I, Lippert H (2011) Endorectal ultrasound in rectal carcinoma–do the literature results really correspond to the realities of routine clinical care? Endoscopy 43(05):425–431CrossRefPubMed
5.
go back to reference Morris OJ, Draganic B, Smith S (2011) Does a learning curve exist in endorectal two-dimensional ultrasound accuracy? Tech Coloproctol 15:301–311CrossRefPubMed Morris OJ, Draganic B, Smith S (2011) Does a learning curve exist in endorectal two-dimensional ultrasound accuracy? Tech Coloproctol 15:301–311CrossRefPubMed
6.
go back to reference Carmody BJ, Otchy DP (2000) Learning curve of transrectal ultrasound. Dis Colon Rectum 43:193–197CrossRefPubMed Carmody BJ, Otchy DP (2000) Learning curve of transrectal ultrasound. Dis Colon Rectum 43:193–197CrossRefPubMed
7.
go back to reference Carter D, Albshesh A, Shimon C, Segal B, Yershov A, Kopylov U, Meyers A, Brzezinski RY, Horin SB, Hoffer O (2023) Automatized detection of crohn s disease in intestinal ultrasound using convolutional neural network. Inflamm Bowel Dis 29:014CrossRef Carter D, Albshesh A, Shimon C, Segal B, Yershov A, Kopylov U, Meyers A, Brzezinski RY, Horin SB, Hoffer O (2023) Automatized detection of crohn s disease in intestinal ultrasound using convolutional neural network. Inflamm Bowel Dis 29:014CrossRef
8.
go back to reference Yin Z, Yao C, Zhang L, Qi S (2023) Application of artificial intelligence in diagnosis and treatment of colorectal cancer: a novel prospect. Front Med 10:1128084CrossRef Yin Z, Yao C, Zhang L, Qi S (2023) Application of artificial intelligence in diagnosis and treatment of colorectal cancer: a novel prospect. Front Med 10:1128084CrossRef
9.
go back to reference Kim J, Ji Eun Oh, Lee J, Kim MJ, Hur BY, Sohn DK, Lee B (2019) Rectal cancer: toward fully automatic discrimination of t2 and t3 rectal cancers using deep convolutional neural network. Int J Imaging Syst Technol 29(3):247–259CrossRef Kim J, Ji Eun Oh, Lee J, Kim MJ, Hur BY, Sohn DK, Lee B (2019) Rectal cancer: toward fully automatic discrimination of t2 and t3 rectal cancers using deep convolutional neural network. Int J Imaging Syst Technol 29(3):247–259CrossRef
10.
go back to reference Qing-Yao Wu, Liu S-L, Sun P, Li Y, Liu G-W, Liu S-S, Ji-Lin Hu, Niu T-Y, Yun Lu (2021) Establishment and clinical application value of an automatic diagnosis platform for rectal cancer t-staging based on a deep neural network. Chin Med J 134(07):821–828CrossRef Qing-Yao Wu, Liu S-L, Sun P, Li Y, Liu G-W, Liu S-S, Ji-Lin Hu, Niu T-Y, Yun Lu (2021) Establishment and clinical application value of an automatic diagnosis platform for rectal cancer t-staging based on a deep neural network. Chin Med J 134(07):821–828CrossRef
11.
go back to reference Huang S-C, Pareek A, Jensen M, Lungren MP, Yeung S, Chaudhari AS (2023) Self-supervised learning for medical image classification: a systematic review and implementation guidelines. NPJ Digit Med 6(1):74CrossRefPubMedPubMedCentral Huang S-C, Pareek A, Jensen M, Lungren MP, Yeung S, Chaudhari AS (2023) Self-supervised learning for medical image classification: a systematic review and implementation guidelines. NPJ Digit Med 6(1):74CrossRefPubMedPubMedCentral
12.
go back to reference Chen Y, Zhang C, Liu Li, Feng C, Dong C, Luo Y, Wan X (2021) USCL: pretraining deep ultrasound image diagnosis model through video contrastive representation learning. Medical image computing and computer assisted intervention–MICCAI 2021: 24th International conference, Strasbourg, France, September 27–October 1, 2021, Proceedings, Part VIII 24. Springer, pp 627–637 Chen Y, Zhang C, Liu Li, Feng C, Dong C, Luo Y, Wan X (2021) USCL: pretraining deep ultrasound image diagnosis model through video contrastive representation learning. Medical image computing and computer assisted intervention–MICCAI 2021: 24th International conference, Strasbourg, France, September 27–October 1, 2021, Proceedings, Part VIII 24. Springer, pp 627–637
15.
go back to reference Kim HE, Cosa-Linan A, Santhanam N, Jannesari M, Maros ME, Ganslandt T (2022) Transfer learning for medical image classification: a literature review. BMC Med Imaging 22(1):1–13CrossRef Kim HE, Cosa-Linan A, Santhanam N, Jannesari M, Maros ME, Ganslandt T (2022) Transfer learning for medical image classification: a literature review. BMC Med Imaging 22(1):1–13CrossRef
16.
go back to reference Chollet F (2017) Xception: deep learning with depthwise separable convolutions. 2017 IEEE Conference on Computer Vision and Pattern Recognition (CVPR). Honolulu, HI, USA, pp 1800–1807CrossRef Chollet F (2017) Xception: deep learning with depthwise separable convolutions. 2017 IEEE Conference on Computer Vision and Pattern Recognition (CVPR). Honolulu, HI, USA, pp 1800–1807CrossRef
17.
go back to reference Szegedy C, Vanhoucke V, Ioffe S, Shlens J, Wojna Z (2016) Rethinking the inception architecture for computer vision. In: Proceedings of the IEEE conference on computer vision and pattern recognition. IEEE Computer Society, Las Vegas, June 27–30, pp 2818–2826 Szegedy C, Vanhoucke V, Ioffe S, Shlens J, Wojna Z (2016) Rethinking the inception architecture for computer vision. In: Proceedings of the IEEE conference on computer vision and pattern recognition. IEEE Computer Society, Las Vegas, June 27–30, pp 2818–2826
18.
go back to reference Tan M, Le Q (2021) Efficientnetv2: smaller models and faster training. International conference on machine learning. PMLR, pp 10096–10106 Tan M, Le Q (2021) Efficientnetv2: smaller models and faster training. International conference on machine learning. PMLR, pp 10096–10106
19.
go back to reference Zoph B, Vasudevan V, Shlens J, Le QV (2018) Learning transferable architectures for scalable image recognition. In: Proceedings of the IEEE conference on computer vision and pattern recognition. IEEE Computer Society, Salt Lake City, June 18–22, pp 8697–8710 Zoph B, Vasudevan V, Shlens J, Le QV (2018) Learning transferable architectures for scalable image recognition. In: Proceedings of the IEEE conference on computer vision and pattern recognition. IEEE Computer Society, Salt Lake City, June 18–22, pp 8697–8710
20.
go back to reference Szegedy C, Ioffe S, Vanhoucke V, Alemi AA (2017) Inception-v4, inception-ResNet and the impact of residual connections on learning. In: Thirty-first AAAI conference on artificial intelligence association for the advancement of artificial intelligance. San Francisco, California, February 4–9, 2017 Szegedy C, Ioffe S, Vanhoucke V, Alemi AA (2017) Inception-v4, inception-ResNet and the impact of residual connections on learning. In: Thirty-first AAAI conference on artificial intelligence association for the advancement of artificial intelligance. San Francisco, California, February 4–9, 2017
21.
go back to reference Liu Z, Mao H, Wu C-Y, Feichtenhofer C, Darrell T, Xie S (2022) A convnet for the 2020s. In: Proceedings of the IEEE/CVF conference on computer vision and pattern recognition. IEEE Computer Society, New Orleans, LA, June 18–22, 2022, pp 11976–11986 Liu Z, Mao H, Wu C-Y, Feichtenhofer C, Darrell T, Xie S (2022) A convnet for the 2020s. In: Proceedings of the IEEE/CVF conference on computer vision and pattern recognition. IEEE Computer Society, New Orleans, LA, June 18–22, 2022, pp 11976–11986
24.
go back to reference Soffer S, Klang E, Shimon O, Nachmias N, Eliakim R, Ben-Horin S, Kopylov U, Barash Y (2020) Deep learning for wireless capsule endoscopy: a systematic review and meta-analysis. Gastrointest Endosc 92(4):831–839CrossRefPubMed Soffer S, Klang E, Shimon O, Nachmias N, Eliakim R, Ben-Horin S, Kopylov U, Barash Y (2020) Deep learning for wireless capsule endoscopy: a systematic review and meta-analysis. Gastrointest Endosc 92(4):831–839CrossRefPubMed
25.
go back to reference Hong Xu, Tang RSY, Lam TYT, Zhao G, Lau JYW, Liu Y, Qi Wu, Rong L, Weiran Xu, Li X et al (2023) Artificial intelligence–assisted colonoscopy for colorectal cancer screening: a multicenter randomized controlled trial. Clin Gastroenterol Hepatol 21(2):337–346CrossRef Hong Xu, Tang RSY, Lam TYT, Zhao G, Lau JYW, Liu Y, Qi Wu, Rong L, Weiran Xu, Li X et al (2023) Artificial intelligence–assisted colonoscopy for colorectal cancer screening: a multicenter randomized controlled trial. Clin Gastroenterol Hepatol 21(2):337–346CrossRef
26.
go back to reference Saqib Mahmood, Mian Muhammad Sadiq Fareed, Gulnaz Ahmed, Farhan Dawood, Shahid Zikria, Ahmad Mostafa, Syeda Fizzah Jilani, Muhammad Asad, and Muhammad Aslam. A robust deep model for classification of peptic ulcer and other digestive tract disorders using endoscopic images. Biomedicines, 10(9):2195, 2022. Saqib Mahmood, Mian Muhammad Sadiq Fareed, Gulnaz Ahmed, Farhan Dawood, Shahid Zikria, Ahmad Mostafa, Syeda Fizzah Jilani, Muhammad Asad, and Muhammad Aslam. A robust deep model for classification of peptic ulcer and other digestive tract disorders using endoscopic images. Biomedicines, 10(9):2195, 2022.
27.
go back to reference Dumoulin FL, Rodriguez-Monaco FD, Ebigbo A, Steinbrück I (2022) Artificial intelligence in the management of barrett s esophagus and early esophageal adenocarcinoma. Cancers 14(8):1918CrossRefPubMedPubMedCentral Dumoulin FL, Rodriguez-Monaco FD, Ebigbo A, Steinbrück I (2022) Artificial intelligence in the management of barrett s esophagus and early esophageal adenocarcinoma. Cancers 14(8):1918CrossRefPubMedPubMedCentral
28.
go back to reference Visaggi P, Barberio B, Gregori D, Azzolina D, Martinato M, Hassan C, Sharma P, Savarino E, de Bortoli N (2022) Systematic review with meta-analysis: artificial intelligence in the diagnosis of oesophageal diseases. Aliment Pharmacol Ther 55(5):528–540CrossRefPubMedPubMedCentral Visaggi P, Barberio B, Gregori D, Azzolina D, Martinato M, Hassan C, Sharma P, Savarino E, de Bortoli N (2022) Systematic review with meta-analysis: artificial intelligence in the diagnosis of oesophageal diseases. Aliment Pharmacol Ther 55(5):528–540CrossRefPubMedPubMedCentral
Metadata
Title
Convolutional neural network deep learning model accurately detects rectal cancer in endoanal ultrasounds
Authors
D. Carter
D. Bykhovsky
A. Hasky
I. Mamistvalov
Y. Zimmer
E. Ram
O. Hoffer
Publication date
01-12-2024
Publisher
Springer International Publishing
Published in
Techniques in Coloproctology / Issue 1/2024
Print ISSN: 1123-6337
Electronic ISSN: 1128-045X
DOI
https://doi.org/10.1007/s10151-024-02917-3

Other articles of this Issue 1/2024

Techniques in Coloproctology 1/2024 Go to the issue