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International Journal of Clinical Oncology

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01-10-2018 | Original Article

Validation of the 8th edition of the AJCC/UICC TNM staging system for tongue squamous cell carcinoma

Authors: Satoshi Kano, Tomohiro Sakashita, Nayuta Tsushima, Takatsugu Mizumachi, Akira Nakazono, Takayoshi Suzuki, Shinichiro Yasukawa, Akihiro Homma

Published in: International Journal of Clinical Oncology | Issue 5/2018

Abstract

Background

The revised 8th edition of the AJCC/UICC staging system was released in January 2017, and depth of invasion (DOI) was added to the new criteria for T classification in oral cavity cancer. In this study, we evaluated whether the 8th edition presents the prognosis and risk of nodal metastasis in patients with squamous cell carcinoma of tongue more accurately than did the 7th edition.

Methods

The data for 112 patients were obtained and reclassified based on the criteria presented in the 8th edition.

Results

Seven patients previously staged as T1 based on the criteria in the 7th edition were reclassified as T2 based on the 8th edition, while 19 T2 patients were reclassified as T3, and 9 T4a patients were reclassified as T3. T3 in the 8th edition represents a homogenous population showing the same prognosis, while T2 in the 8th edition represents a heterogenous population. Nodal metastasis was significantly correlated with T classification in both editions and DOI. However, neither the T classification in the 7th or 8th edition, nor DOI could predict the probability of potential nodal metastasis in patients with cN0 disease.

Conclusions

The classification on T3 in the 8th edition can be seen as reasonable with regard to prognosis. Nodal metastasis was significantly correlated with T classification and DOI; however, the probability of subsequent nodal metastasis in patients with T2N0 was almost same for the criteria in the 7th and 8th editions, therefore, the same careful management as before is required for patients with N0 disease.

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Title: Validation of the 8th edition of the AJCC/UICC TNM staging system for tongue squamous cell carcinoma
Authors: Satoshi Kano
Tomohiro Sakashita
Nayuta Tsushima
Takatsugu Mizumachi
Akira Nakazono
Takayoshi Suzuki
Shinichiro Yasukawa
Akihiro Homma
Publication date: 01-10-2018
Publisher: Springer Japan
Published in: International Journal of Clinical Oncology / Issue 5/2018
Print ISSN: 1341-9625
Electronic ISSN: 1437-7772
DOI: https://doi.org/10.1007/s10147-018-1276-5

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Abstract

Background

Methods

Results

Conclusions

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