Skip to main content
Top
Published in: Neurosurgical Review 1/2007

01-01-2007 | Case Report

Giant cavernous hemangiomas: report of three cases

Authors: E. J. van Lindert, T. C. Tan, J. A. Grotenhuis, P. Wesseling

Published in: Neurosurgical Review | Issue 1/2007

Login to get access

Abstract

Giant cavernous hemangiomas occur very rarely, and little has been reported about their behavior. In this case report three cavernous hemangiomas with a diametric measure between 6 cm and 7 cm and distinct features will be described. A 36-year-old female patient presented with headache and nausea. A CT scan disclosed a large circumscribed tumor with strong contrast enhancement in the temporo-parieto-occipital region of the right cerebral hemisphere and extension into the right cerebellar hemisphere. A 35-year-old woman was admitted to our emergency ward with a generalized seizure and a dilated pupil. The CT scan showed an extensive left frontal lesion containing a substantial hyperintense part, suspicious for hemorrhage. A 3-year-old girl was admitted with generalized seizure and progressively declining consciousness. A large left frontotemporal paraventricular multi-cystic lesion was encountered on the CT scan. All three patients were operated on. Two recovered very well. In the case of the 3-year-old girl stable disease was reached. Giant cavernomas do not differ from average-sized cavernomas in clinical, surgical or histopathological presentation but may differ radiologically. However, the possible diagnosis of cavernoma can be overlooked, due to their size and possible differential diagnosis.
Literature
1.
go back to reference Aiba T, Tanaka R, Koike T, Kameyama S, Takeda N, Komata T (1995) Natural history of intracranial cavernous malformations. J Neurosurg 83:56–59PubMed Aiba T, Tanaka R, Koike T, Kameyama S, Takeda N, Komata T (1995) Natural history of intracranial cavernous malformations. J Neurosurg 83:56–59PubMed
2.
go back to reference Anderson RC, Connolly ES Jr, Ozduman K, Laurans MSH, Gunel M, Khandji A, Faust PL, Sisti MB (2003) Clinicopathological review: giant intraventricular cavernous malformation. Neurosurgery 53:374–379PubMedCrossRef Anderson RC, Connolly ES Jr, Ozduman K, Laurans MSH, Gunel M, Khandji A, Faust PL, Sisti MB (2003) Clinicopathological review: giant intraventricular cavernous malformation. Neurosurgery 53:374–379PubMedCrossRef
3.
go back to reference Awad IA, Robinson JR Jr, Mohanty S, Estes ML (1993) Mixed vascular malformations of the brain: clinical and pathogenetic considerations. Neurosurgery 33:179–188PubMed Awad IA, Robinson JR Jr, Mohanty S, Estes ML (1993) Mixed vascular malformations of the brain: clinical and pathogenetic considerations. Neurosurgery 33:179–188PubMed
4.
go back to reference Bertalanffy H, Benes L, Miyazawa T, Alberti O, Siegel AM, Sure U (2002) Cerebral cavernomas in the adult. Review of the literature and analysis of 72 surgically treated patients. Neurosurg Rev 25:1–53PubMedCrossRef Bertalanffy H, Benes L, Miyazawa T, Alberti O, Siegel AM, Sure U (2002) Cerebral cavernomas in the adult. Review of the literature and analysis of 72 surgically treated patients. Neurosurg Rev 25:1–53PubMedCrossRef
5.
go back to reference Chicani CF, Miller NR, Tamargo RJ (2003) Giant cavernous malformation of the occipital lobe. J Neuroophthalmol 23:151–153PubMed Chicani CF, Miller NR, Tamargo RJ (2003) Giant cavernous malformation of the occipital lobe. J Neuroophthalmol 23:151–153PubMed
6.
go back to reference Churchyard A, Khangure M, Grainger K (1992) Cerebral cavernous angioma: a potentially benign condition? Successful treatment in 16 cases. J Neurol Neurosurg Psychiatry 55:1040–1045PubMed Churchyard A, Khangure M, Grainger K (1992) Cerebral cavernous angioma: a potentially benign condition? Successful treatment in 16 cases. J Neurol Neurosurg Psychiatry 55:1040–1045PubMed
7.
go back to reference Clatterbuck RE, Moriarity JL, Elmaci I, Lee RR, Breiter SN, Rigamonti D (2000) Dynamic nature of cavernous malformations: a prospective magnetic resonance imaging study with volumetric analysis. J Neurosurg 93:981–986PubMed Clatterbuck RE, Moriarity JL, Elmaci I, Lee RR, Breiter SN, Rigamonti D (2000) Dynamic nature of cavernous malformations: a prospective magnetic resonance imaging study with volumetric analysis. J Neurosurg 93:981–986PubMed
8.
go back to reference de Andrade GC, Prandini MN, Braga FM (2002) [Giant cavernous angioma: report of two cases]. Arq Neuropsiquiatr 60:481–486PubMed de Andrade GC, Prandini MN, Braga FM (2002) [Giant cavernous angioma: report of two cases]. Arq Neuropsiquiatr 60:481–486PubMed
9.
go back to reference Del CO Jr, Kelly DL Jr, Elster AD, Craven TE (1991) An analysis of the natural history of cavernous angiomas. J Neurosurg 75:702–708 Del CO Jr, Kelly DL Jr, Elster AD, Craven TE (1991) An analysis of the natural history of cavernous angiomas. J Neurosurg 75:702–708
10.
go back to reference Detwiler PW, Porter RW, Zabramski JM, Spetzler RF (1997) De novo formation of a central nervous system cavernous malformation: implications for predicting risk of hemorrhage. Case report and review of the literature. J Neurosurg 87:629–632PubMed Detwiler PW, Porter RW, Zabramski JM, Spetzler RF (1997) De novo formation of a central nervous system cavernous malformation: implications for predicting risk of hemorrhage. Case report and review of the literature. J Neurosurg 87:629–632PubMed
11.
go back to reference Duffau H, Capelle L, Sichez JP, Faillot T, Bitar A, Arthuis F, Van ER, Fohanno D (1997) Early radiologically proven rebleeding from intracranial cavernous angiomas: report of 6 cases and review of the literature. Acta Neurochir (Wien) 139:914–922CrossRef Duffau H, Capelle L, Sichez JP, Faillot T, Bitar A, Arthuis F, Van ER, Fohanno D (1997) Early radiologically proven rebleeding from intracranial cavernous angiomas: report of 6 cases and review of the literature. Acta Neurochir (Wien) 139:914–922CrossRef
12.
go back to reference Flemming KD, Goodman BP, Meyer FB (2003) Successful brainstem cavernous malformation resection after repeated hemorrhages during pregnancy. Surg Neurol 60:545–547PubMedCrossRef Flemming KD, Goodman BP, Meyer FB (2003) Successful brainstem cavernous malformation resection after repeated hemorrhages during pregnancy. Surg Neurol 60:545–547PubMedCrossRef
13.
go back to reference Gelal F, Feran H, Rezanko T, Dirim Vidinli B (2005) Giant cavernous angioma of the temporal lobe: a case report and review of the literature. Acta Radiol 46:310–313PubMedCrossRef Gelal F, Feran H, Rezanko T, Dirim Vidinli B (2005) Giant cavernous angioma of the temporal lobe: a case report and review of the literature. Acta Radiol 46:310–313PubMedCrossRef
14.
go back to reference Hayashi T, Fukui M, Shoyima K, Utsonomiya H, Kawasaki K (1985) Giant cerebellar hemangioma in an infant. Childs Nerv Syst 1:230–233PubMedCrossRef Hayashi T, Fukui M, Shoyima K, Utsonomiya H, Kawasaki K (1985) Giant cerebellar hemangioma in an infant. Childs Nerv Syst 1:230–233PubMedCrossRef
16.
go back to reference Hyodo A, Yanaka K, Higuchi O, Tomono Y, Nose T (2000) Giant interdural cavernous hemangioma at the convexity. Case illustration. J Neurosurg 92:503PubMed Hyodo A, Yanaka K, Higuchi O, Tomono Y, Nose T (2000) Giant interdural cavernous hemangioma at the convexity. Case illustration. J Neurosurg 92:503PubMed
17.
go back to reference Kawagishi J, Suzuki M, Kayama T, Yoshimoto T (1993) Huge multilobular cavernous angioma in an infant: case report. Neurosurgery 32:1028–1031PubMed Kawagishi J, Suzuki M, Kayama T, Yoshimoto T (1993) Huge multilobular cavernous angioma in an infant: case report. Neurosurgery 32:1028–1031PubMed
18.
go back to reference Khosla VK, Banerjee AK, Mathuriya SN, Mehta S (1984) Giant cystic cavernoma in a child. Case report. J Neurosurg 60:1297–1299PubMed Khosla VK, Banerjee AK, Mathuriya SN, Mehta S (1984) Giant cystic cavernoma in a child. Case report. J Neurosurg 60:1297–1299PubMed
19.
go back to reference Kim DS, Park YG, Choi JU, Chung SS, Lee KC (1997) An analysis of the natural history of cavernous malformations. Surg Neurol 48:9–17PubMedCrossRef Kim DS, Park YG, Choi JU, Chung SS, Lee KC (1997) An analysis of the natural history of cavernous malformations. Surg Neurol 48:9–17PubMedCrossRef
20.
go back to reference Kocak A, Cayli SR, Onal SC, Kutlu R, Aydin N (2002) Dural cavernous hemangioma originating from superior petrosal sinus. J Neurosurg Sci 46:143–146PubMed Kocak A, Cayli SR, Onal SC, Kutlu R, Aydin N (2002) Dural cavernous hemangioma originating from superior petrosal sinus. J Neurosurg Sci 46:143–146PubMed
21.
go back to reference Lawton MT, Vates GE, Quinones-Hinojosa A, McDonald W, Marchuk D (2004) Giant infiltrative cavernous malformation: clinical presentation, intervention, and genetic analysis: case report. Neurosurgery 55:988–995CrossRef Lawton MT, Vates GE, Quinones-Hinojosa A, McDonald W, Marchuk D (2004) Giant infiltrative cavernous malformation: clinical presentation, intervention, and genetic analysis: case report. Neurosurgery 55:988–995CrossRef
22.
go back to reference Maraire JN, Awad IA (1995) Intracranial cavernous malformations: lesion behavior and management strategies. Neurosurgery 37:591–605PubMed Maraire JN, Awad IA (1995) Intracranial cavernous malformations: lesion behavior and management strategies. Neurosurgery 37:591–605PubMed
23.
go back to reference Moriarity JL, Wetzel M, Clatterbuck RE, Javedan S, Sheppard JM, Hoenig-Rigamonti K, Crone NE, Breiter SN, Lee RR, Rigamonti D (1999) The natural history of cavernous malformations: a prospective study of 68 patients. Neurosurgery 44:1166–1171PubMedCrossRef Moriarity JL, Wetzel M, Clatterbuck RE, Javedan S, Sheppard JM, Hoenig-Rigamonti K, Crone NE, Breiter SN, Lee RR, Rigamonti D (1999) The natural history of cavernous malformations: a prospective study of 68 patients. Neurosurgery 44:1166–1171PubMedCrossRef
24.
go back to reference Mottolese C, Hermier M, Stan H, Jouvet A, Saint-Pierre G, Froment JC, Bret P, Lapras C (2001) Central nervous system cavernomas in the pediatric age group. Neurosurg Rev 24:55–71PubMedCrossRef Mottolese C, Hermier M, Stan H, Jouvet A, Saint-Pierre G, Froment JC, Bret P, Lapras C (2001) Central nervous system cavernomas in the pediatric age group. Neurosurg Rev 24:55–71PubMedCrossRef
25.
go back to reference Ojemann RG, Crowell RM, Ogilvy CS (1995) Cranial and spinal cavernous malformations. In: Ojemann RG, Ogilvy CS, Crowell RM, Heros RC (eds) Surgical management of neurovascular disease. Williams & Wilkins, Baltimore, pp 538–557 Ojemann RG, Crowell RM, Ogilvy CS (1995) Cranial and spinal cavernous malformations. In: Ojemann RG, Ogilvy CS, Crowell RM, Heros RC (eds) Surgical management of neurovascular disease. Williams & Wilkins, Baltimore, pp 538–557
26.
go back to reference Penfield W, Ward A (1948) Calcifying epileptogenic lesions. Haemangioma calcificans. Report of a case. Arch Neurol Psychiatry 60:20–36PubMed Penfield W, Ward A (1948) Calcifying epileptogenic lesions. Haemangioma calcificans. Report of a case. Arch Neurol Psychiatry 60:20–36PubMed
27.
go back to reference Porter PJ, Willinsky RA, Harper W, Wallace MC (1997) Cerebral cavernous malformations: natural history and prognosis after clinical deterioration with or without hemorrhage. J Neurosurg 87:190–197PubMed Porter PJ, Willinsky RA, Harper W, Wallace MC (1997) Cerebral cavernous malformations: natural history and prognosis after clinical deterioration with or without hemorrhage. J Neurosurg 87:190–197PubMed
28.
go back to reference Pozzati E, Acciarri N, Tognetti F, Marliani F, Giangaspero F (1996) Growth, subsequent bleeding, and de novo appearance of cerebral cavernous angiomas. Neurosurgery 38:662–669PubMedCrossRef Pozzati E, Acciarri N, Tognetti F, Marliani F, Giangaspero F (1996) Growth, subsequent bleeding, and de novo appearance of cerebral cavernous angiomas. Neurosurgery 38:662–669PubMedCrossRef
29.
go back to reference Raychaudhuri R, Batjer HH, Awad IA (2005) Intracranial cavernous angioma: a practical review of clinical and biological aspects. Surg Neurol 63:319–328PubMedCrossRef Raychaudhuri R, Batjer HH, Awad IA (2005) Intracranial cavernous angioma: a practical review of clinical and biological aspects. Surg Neurol 63:319–328PubMedCrossRef
30.
go back to reference Requena I, Arias M, Lopez-Ibor L, Pereiro I, Barba A, Alonso A, Monton E (1991) Cavernomas of the central nervous system: clinical and neuroimaging manifestations in 47 patients. J Neurol Neurosurg Psychiatry 54:590–594PubMedCrossRef Requena I, Arias M, Lopez-Ibor L, Pereiro I, Barba A, Alonso A, Monton E (1991) Cavernomas of the central nervous system: clinical and neuroimaging manifestations in 47 patients. J Neurol Neurosurg Psychiatry 54:590–594PubMedCrossRef
31.
go back to reference Reyns N, Assaker R, Louis E, Lejeune JP (1999) Intraventricular cavernomas: three cases and review of the literature. Neurosurgery 44:648–654PubMedCrossRef Reyns N, Assaker R, Louis E, Lejeune JP (1999) Intraventricular cavernomas: three cases and review of the literature. Neurosurgery 44:648–654PubMedCrossRef
32.
go back to reference Rigamonti D, Drayer BP, Johnson PC, Hadley MN, Zabramski J, Spetzler RF (1987) The MRI appearance of cavernous malformations (angiomas). J Neurosurg 67:518–524PubMed Rigamonti D, Drayer BP, Johnson PC, Hadley MN, Zabramski J, Spetzler RF (1987) The MRI appearance of cavernous malformations (angiomas). J Neurosurg 67:518–524PubMed
33.
go back to reference Robinson JR, Awad IA, Little JR (1991) Natural history of the cavernous angioma. J Neurosurg 75:709–714PubMed Robinson JR, Awad IA, Little JR (1991) Natural history of the cavernous angioma. J Neurosurg 75:709–714PubMed
34.
go back to reference Rosso D, Lee DH, Ferguson GG, Tailor C, Iskander S, Hammond RR (2003) Dural cavernous angioma: a preoperative diagnostic challenge. Can J Neurol Sci 30:272–277PubMed Rosso D, Lee DH, Ferguson GG, Tailor C, Iskander S, Hammond RR (2003) Dural cavernous angioma: a preoperative diagnostic challenge. Can J Neurol Sci 30:272–277PubMed
35.
go back to reference Sansone ME, Liwnicz BH, Mandybur TI (1980) Giant pituitary cavernous hemangioma: case report. J Neurosurg 53:124–126PubMed Sansone ME, Liwnicz BH, Mandybur TI (1980) Giant pituitary cavernous hemangioma: case report. J Neurosurg 53:124–126PubMed
36.
go back to reference Savoiardo M, Strada L, Passerini A (1983) Intracranial cavernous hemangiomas: neuroradiologic review of 36 operated cases. Am J Neuroradiol 4:945–950PubMed Savoiardo M, Strada L, Passerini A (1983) Intracranial cavernous hemangiomas: neuroradiologic review of 36 operated cases. Am J Neuroradiol 4:945–950PubMed
37.
go back to reference Scott RM, Barnes P, Kupsky W, Adelman LS (1992) Cavernous angiomas of the central nervous system in children. J Neurosurg 76:38–46PubMed Scott RM, Barnes P, Kupsky W, Adelman LS (1992) Cavernous angiomas of the central nervous system in children. J Neurosurg 76:38–46PubMed
38.
go back to reference Steiger HJ, Markwalder TM, Reulen HJ (1987) Clinicopathological relations of cerebral cavernous angiomas: observations in eleven cases. Neurosurgery 21:879–884PubMed Steiger HJ, Markwalder TM, Reulen HJ (1987) Clinicopathological relations of cerebral cavernous angiomas: observations in eleven cases. Neurosurgery 21:879–884PubMed
39.
go back to reference Sure U, Freman S, Bozinov O, Benes L, Siegel AM, Bertalanffy H (2005) Biological activity of adult cavernous malformations: a study of 56 patients. J Neurosurg 102:342–347PubMedCrossRef Sure U, Freman S, Bozinov O, Benes L, Siegel AM, Bertalanffy H (2005) Biological activity of adult cavernous malformations: a study of 56 patients. J Neurosurg 102:342–347PubMedCrossRef
40.
go back to reference Thiex R, Kruger R, Friese S, Gronewaller E, Kuker W (2003) Giant cavernoma of the brain stem: value of delayed MR imaging after contrast injection. Eur Radiol 13 [Suppl 4]:L219–L225CrossRef Thiex R, Kruger R, Friese S, Gronewaller E, Kuker W (2003) Giant cavernoma of the brain stem: value of delayed MR imaging after contrast injection. Eur Radiol 13 [Suppl 4]:L219–L225CrossRef
41.
go back to reference Voelker JL, Stewart DH, Schochet SS Jr (1998) Giant intracranial and extracranial cavernous malformation. Case report. J Neurosurg 89:465–469PubMed Voelker JL, Stewart DH, Schochet SS Jr (1998) Giant intracranial and extracranial cavernous malformation. Case report. J Neurosurg 89:465–469PubMed
42.
go back to reference Zabramski JM, Wascher TM, Spetzler RF, Johnson B, Golfinos J, Drayer BP, Brown B, Rigamonti D, Brown G (1994) The natural history of familial cavernous malformations: results of an ongoing study. J Neurosurg 80:422–432PubMedCrossRef Zabramski JM, Wascher TM, Spetzler RF, Johnson B, Golfinos J, Drayer BP, Brown B, Rigamonti D, Brown G (1994) The natural history of familial cavernous malformations: results of an ongoing study. J Neurosurg 80:422–432PubMedCrossRef
Metadata
Title
Giant cavernous hemangiomas: report of three cases
Authors
E. J. van Lindert
T. C. Tan
J. A. Grotenhuis
P. Wesseling
Publication date
01-01-2007
Publisher
Springer-Verlag
Published in
Neurosurgical Review / Issue 1/2007
Print ISSN: 0344-5607
Electronic ISSN: 1437-2320
DOI
https://doi.org/10.1007/s10143-006-0042-8

Other articles of this Issue 1/2007

Neurosurgical Review 1/2007 Go to the issue

Acknowledgement to Referees

Referees 2006