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01-12-2024 | Review Article

Advances in far-infrared research: therapeutic mechanisms of disease and application in cancer detection

Authors: Jianming Wen, Junrun Pan, Jijie Ma, Xinyang Ge, Zisheng Xu, Xiaolin Wang, Zhong Lv

Published in: Lasers in Medical Science | Issue 1/2024

Abstract

Far infrared (FIR) irradiation is commonly used as a convenient, non-contact, non-invasive treatment for diseases such as myocardial ischemia, diabetes, and chronic kidney disease. In this review, we focus on reviewing the potential therapeutic mechanisms of FIR and its cutting-edge applications in cancer detection. Firstly, we searched the relevant literature in the last decade for systematic screening and briefly summarized the biophysical properties of FIR. We then focused on the possible mechanisms of FIR in wound healing, cardiovascular diseases, and other chronic diseases. In addition, we review recent applications of FIR in cancer detection, where Fourier transform infrared spectroscopy and infrared thermography provide additional diagnostic methods for the medical diagnosis of cancer. Finally, we conclude and look into the future development of FIR for disease treatment and cancer detection. As a high-frequency non-ionizing wave, FIR has the advantages of safety, convenience, and low cost. We hope that this review can provide biological information reference and relevant data support for those who are interested in FIR and related high-frequency non-ionizing waves, to promote the further application of FIR in the biomedical field.

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Sutton KM, Hunter EG, Logsdon B, Santella B, Kitzman PH (2021) The role of physical therapy in multiple risk factor management poststroke: a scoping review. J Geriatr Phys Ther 44:165–174. https://doi.org/10.1519/jpt.0000000000000248CrossRefPubMed

Yang M, Yang T, Mao C (2019) Enhancement of photodynamic cancer therapy by physical and chemical factors. Angew Chem Int Ed 58:14066–14080. https://doi.org/10.1002/anie.201814098CrossRef

Hsu YH, Chen YW, Cheng CY, Lee SL, Chiu TH, Chen CH (2019) Detecting the limits of the biological effects of far-infrared radiation on epithelial cells. Sci Rep 9:1–9. https://doi.org/10.1038/s41598-019-48187-0CrossRef

Yao X, Wei W, Li J, Wang L, Xu Z, Wan Y et al (2014) A comparison of mammography, ultrasonography, and far-infrared thermograhy with pathological results in screening and early diagnosis of breast cancer. Asian Biomed 8:11–19. https://doi.org/10.5372/1905-7415.0801.257CrossRef

Bunaciu AA, Vu Dang H, Aboul-Enein HY (2015) Applications of ft-ir spectrophotometry in cancer diagnostics. Crit Rev Anal Chem 45:156–165. https://doi.org/10.1080/10408347.2014.904733CrossRefPubMed

Vatansever F, Hamblin MR (2012) Far infrared radiation (fir): its biological effects and medical applications. Photon Lasers Med 4:255–266. https://doi.org/10.1515/plm-2012-0034CrossRef

Carrick FR, Valerio LSA, Gonzalez-Vega MN, Engel D, Sugaya K (2021) Accelerated wound healing using a novel far-infrared ceramic blanket. Life-Basel 11:1–15. https://doi.org/10.3390/life11090878CrossRef

Inoue S, Takemoto M, Chishaki A, Ide T, Nishizaka M, Miyazono M et al (2012) Leg heating using far infra-red radiation in patients with chronic heart failure acutely improves the hemodynamics, vascular endothelial function, and oxidative stress. Intern Med 51:2263–2270. https://doi.org/10.2169/internalmedicine.51.7115CrossRefPubMed

Sobajima M, Nozawa T, Shida T, Ohori T, Suzuki T, Matsuki A et al (2011) Repeated sauna therapy attenuates ventricular remodeling after myocardial infarction in rats by increasing coronary vascularity of noninfarcted myocardium. Am J Physiol-Heart Circ Physiol 301:H548–H554. https://doi.org/10.1152/ajpheart.00103.2011CrossRefPubMed

10.

Salm DC, Oliveira Belmonte LA, Emer AA, Leonel LdS, de Brito RN, da Rocha CC et al (2019) Aquatic exercise and far infrared (fir) modulates pain and blood cytokines in fibromyalgia patients: a double-blind, randomized, placebo-controlled pilot study. J Neuroimmunol 337:1–35. https://doi.org/10.1016/j.jneuroim.2019.577077CrossRef

11.

Chang Y (2018) The effect of far infrared radiation therapy on inflammation regulation in lipopolysaccharide-induced peritonitis in mice. SAGE Open Med 6:1–7. https://doi.org/10.1177/2050312118798941CrossRef

12.

Sobajima M, Nozawa T, Ihori H, Shida T, Ohori T, Suzuki T et al (2013) Repeated sauna therapy improves myocardial perfusion in patients with chronically occluded coronary artery-related ischemia. Int J Cardiol 167:237–243. https://doi.org/10.1016/j.ijcard.2011.12.064CrossRefPubMed

13.

Yamane H, Araki R, Doi A, Sato F, Tanaka K, Miyazaki N et al (2021) Successful wound healing of refractory digital ulcer in patient with systemic sclerosis by waon therapy. J Cardiol Cases 24:190–192. https://doi.org/10.1016/j.jccase.2021.04.001CrossRefPubMedPubMedCentral

14.

Chiu H-W, Chen C-H, Chang J-N, Chen C-H, Hsu Y-H (2016) Far-infrared promotes burn wound healing by suppressing nlrp3 inflammasome caused by enhanced autophagy. J Mol Med Jmm 94:809–819. https://doi.org/10.1007/s00109-016-1389-0CrossRef

15.

Chen X, Zhang H, Zeng W, Wang N, Lo HH, Ip CK et al (2022) Far infrared irradiation suppresses experimental arthritis in rats by down-regulation of genes involved inflammatory response and autoimmunity. J Adv Res 38:107–118. https://doi.org/10.1016/j.jare.2021.08.015CrossRefPubMed

16.

Mu Y, Jin Z, Yan Y, Tao J (2021) The possibility of using far infrared fabrics to promote wound healing from the cellular level. Fibers Polym 22:2206–2214. https://doi.org/10.1007/s12221-021-0182-zCrossRef

17.

Hsu Y-H, Lin Y-F, Chen C-H, Chiu Y-J, Chiu H-W (2017) Far infrared promotes wound healing through activation of notch1 signaling. J Mol Med Jmm 95:1203–1213. https://doi.org/10.1007/s00109-017-1580-yCrossRef

18.

Chen RF, Liu KF, Lee SS, Huang SH, Wu YC, Lin YN et al (2021) Far-infrared therapy accelerates diabetic wound healing via recruitment of tissue angiogenesis in a full-thickness wound healing model in rats. Biomedicines 9:1–11. https://doi.org/10.3390/biomedicines9121922CrossRef

19.

Akasaki Y, Miyata M, Eto H, Shirasawa T, Hamada N, Ikeda Y et al (2006) Repeated thermal therapy up-regulates endothelial nitric oxide synthase and augments angiogenesis in a mouse model of hindlimb ischemia. Circ J 70:463–470. https://doi.org/10.1253/circj.70.463CrossRefPubMed

20.

Chen CH, Chen MC, Hsu YH, Chou TC (2022) Far-infrared radiation alleviates cisplatin-induced vascular damage and impaired circulation via activation of hif-1alpha. Cancer Sci 113:2194–2206. https://doi.org/10.1111/cas.15371CrossRefPubMedPubMedCentral

21.

Kim S, Lee I, Song H-J, Choi S-j, Nagar H, Kim S-m et al (2019) Far-infrared-emitting sericite board upregulates endothelial nitric oxide synthase activity through increasing biosynthesis of tetrahydrobiopterin in endothelial cells. Evid-Based Complement Altern Med 2019:1–9. https://doi.org/10.1155/2019/1813282CrossRef

22.

Park J-H, Lee S, Cho D-H, Park YM, Kang D-H, Jo I (2013) Far-infrared radiation acutely increases nitric oxide production by increasing ca2+ mobilization and ca2+/calmodulin-dependent protein kinase ii-mediated phosphorylation of endothelial nitric oxide synthase at serine 1179. Biochem Biophys Res Commun 436:601–606. https://doi.org/10.1016/j.bbrc.2013.06.003CrossRefPubMed

23.

Chen C-H, Chen T-H, Wu M-Y, Chou T-C, Chen J-R, Wei M-J et al (2017) Far-infrared protects vascular endothelial cells from advanced glycation end products-induced injury via plzf- mediated autophagy in diabetic mice. Sci Rep 7:1–14. https://doi.org/10.1038/srep40442CrossRef

24.

Lin CC, Yang WC, Chen MC, Liu WS, Yang CY, Lee PC (2013) Effect of far infrared therapy on arteriovenous fistula maturation: an open-label randomized controlled trial. Am J Kidney Dis 62:304–311. https://doi.org/10.1053/j.ajkd.2013.01.015CrossRefPubMed

25.

Chen C-F, Lee C-Y, Chen F-A, Yang C-Y, Chen T-H, Ou S-M et al (2022) Far-infrared therapy improves arteriovenous fistula patency and decreases plasma asymmetric dimethylarginine in patients with advanced diabetic kidney disease: a prospective randomized controlled trial. J Clin Med 11:1–13. https://doi.org/10.3390/jcm11144168CrossRef

26.

Lindhard K, Rix M, Heaf JG, Hansen HP, Pedersen BL, Jensen BL et al (2021) Effect of far infrared therapy on arteriovenous fistula maturation, survival and stenosis in hemodialysis patients, a randomized, controlled clinical trial: the faith on fistula trial. BMC Nephrol 22:1–9. https://doi.org/10.1186/s12882-021-02476-xCrossRef

27.

Hadimeri U, Warme A, Stegmayr B (2017) A single treatment, using far infrared light improves blood flow conditions in arteriovenous fistula. Clin Hemorheol Microcirc 66:211–217. https://doi.org/10.3233/ch-170254CrossRefPubMed

28.

Chen C-F, Yang W-C, Lin C-C (2016) An update of the effect of far infrared therapy on arteriovenous access in end-stage renal disease patients. J Vasc Access 17:293–298. https://doi.org/10.5301/jva.5000561CrossRefPubMed

29.

Cheng Y-C, Lung C-W, Jan Y-K, Kuo F-C, Lin Y-S, Lo Y-C et al (2020) Evaluating the far-infrared radiation bioeffects on micro vascular dysfunction, nervous system, and plantar pressure in diabetes mellitus. Int J Lower Extrem Wounds 19:125–131. https://doi.org/10.1177/1534734619880741CrossRef

30.

Hsu YH, Chen YC, Chen YW, Chiu TH, Kuo YT, Chen CH (2020) Far-infrared radiation prevents decline in β-cell mass and function in diabetic mice via the mitochondria-mediated sirtuin1 pathway. Metabolism 104:1–24. https://doi.org/10.1016/j.metabol.2020.154143CrossRef

31.

Sharma N, Shin EJ, Kim NH, Cho EH, Jeong JH, Jang CG et al (2019) Protective potentials of far-infrared ray against neuropsychotoxic conditions. Neurochem Int 122:144–148. https://doi.org/10.1016/j.neuint.2018.11.019CrossRefPubMed

32.

Sharma N, Shin E-J, Kim NH, Cho E-H, Bao Trong N, Jeong JH et al (2019) Far-infrared ray-mediated antioxidant potentials are important for attenuating psychotoxic disorders. Curr Neuropharmacol 17:990–1002. https://doi.org/10.2174/1570159x17666190228114318CrossRefPubMedPubMedCentral

33.

Li K, Zhang Z, Liu NF, Sadigh P, Evans VJ, Zhou HH et al (2018) Far-infrared radiation thermotherapy improves tissue fibrosis in chronic extremity lymphedema. Lymphat Res Biol 16:248–257. https://doi.org/10.1089/lrb.2016.0057CrossRefPubMed

34.

Xia L, Cui C, Nicoli F, Al-Mousawi A, Campisi CC, Lazzeri D et al (2022) Far infrared radiation therapy for gynecological cancer-related lymphedema is an effective and oncologically safe treatment: a randomized-controlled trial. Lymphat Res Biol 20:164–174. https://doi.org/10.1089/lrb.2019.0061CrossRefPubMed

35.

Gonzalez-Hernandez J-L, Recinella AN, Kandlikar SG, Dabydeen D, Medeiros L, Phatak P (2019) Technology, application and potential of dynamic breast thermography for the detection of breast cancer. Int J Heat Mass Transf 131:558–573. https://doi.org/10.1016/j.ijheatmasstransfer.2018.11.089CrossRef

36.

Guirro RRD, Vaz M, das Neves LMS, Dibai AV, Carrara HHA, Guirro ECD (2017) Accuracy and reliability of infrared thermography in assessment of the breasts of women affected by cancer. J Med Syst 41:1–6. https://doi.org/10.1007/s10916-017-0730-7CrossRef

37.

Morales-Cervantes A, Kolosovas-Machuca ES, Guevara E, Reducindo MM, Hernandez ABB, Garcia MR et al (2018) An automated method for the evaluation of breast cancer using infrared thermography. Excli J 17:989–998. https://doi.org/10.17179/excli2018-1735CrossRefPubMedPubMedCentral

38.

Khan AA, Arora AS (2021) Thermography as an economical alternative modality to mammography for early detection of breast cancer. J Healthc Eng 2021:1–8. https://doi.org/10.1155/2021/5543101CrossRef

39.

Singh D, Singh AK (2020) Role of image thermography in early breast cancer detection- past, present and future. Comput Methods Programs Biomed 183:1–9. https://doi.org/10.1016/j.cmpb.2019.105074CrossRef

40.

Lin PH, Echeverria A, Poi MJ (2017) Infrared thermography in the diagnosis and management of vasculitis. J Vasc Surg Cases Innov Tech 3:112–114. https://doi.org/10.1016/j.jvscit.2016.12.002CrossRefPubMedPubMedCentral

41.

Kwok G, Yip J, Yick K-L, Cheung M-C, Tse C-Y, Ng S-P et al (2017) Postural screening for adolescent idiopathic scoliosis with infrared thermography. Sci Rep 7:1–8. https://doi.org/10.1038/s41598-017-14556-wCrossRef

42.

Osama O, Abdelaziz M, Diaa A, Aly O, Medhat I (2015) Computational notes on the effect of solvation on the electronic properties of glycine. Der Pharma Chemica 7:337–380

43.

Atta D, Mahmoud AE, Fakhry A (2019) Protein structure from the essential amino acids to the 3d structure. Biointerface Res Appl Chem 9:3817–3824. https://doi.org/10.33263/briac91.817824CrossRef

44.

Goormaghtigh E, Ruysschaert J-M, Raussens V (2006) Evaluation of the information content in infrared spectra for protein secondary structure determination. Biophys J 90:46–57. https://doi.org/10.1529/biophysj.105.072017CrossRef

45.

Diaa A, Ahmed F, Medhat I (2015) Chitosan membrane as an oil carrier: spectroscopic and modeling analyses. Der Pharma Chemica 7:357–361

46.

Neto V, Esteves-Ferreira S, Inacio I, Alves M, Dantas R, Almeida I et al (2022) Metabolic profile characterization of different thyroid nodules using ftir spectroscopy: a review. Metabolites 12:1–15. https://doi.org/10.3390/metabo12010053CrossRef

47.

Li L, Wu J, Yang L, Wang H, Xu Y, Shen K (2021) Fourier transform infrared spectroscopy: an innovative method for the diagnosis of ovarian cancer. Cancer Manag Res 13:2389–2399. https://doi.org/10.2147/cmar.S291906CrossRefPubMedPubMedCentral

48.

Kumar S, Srinivasan A, Nikolajeff F (2018) Role of infrared spectroscopy and imaging in cancer diagnosis. Curr Med Chem 25:1055–1072. https://doi.org/10.2174/0929867324666170523121314CrossRefPubMed

49.

Sheng D, Xu F, Yu Q, Fang T, Xia J, Li S et al (2015) A study of structural differences between liver cancer cells and normal liver cells using ftir spectroscopy. J Mol Struct 1099:18–23. https://doi.org/10.1016/j.molstruc.2015.05.054CrossRef

50.

Thumanu K, Sangrajrang S, Khuhaprema T, Kalalak A, Tanthanuch W, Pongpiachan S et al (2014) Diagnosis of liver cancer from blood sera using ftir microspectroscopy: a preliminary study. J Biophotonics 7:222–231. https://doi.org/10.1002/jbio.201300183CrossRefPubMed

51.

Yang X, Ou QH, Yang WY, Shi YM, Liu G (2021) Diagnosis of liver cancer by ftir spectra of serum. Spectrochim Acta Part A-Mol Biomol Spectrosc 263:1–7. https://doi.org/10.1016/j.saa.2021.120181CrossRef

52.

Xie Y-b, Liu Q, He F, Guo C-g, C-f W, Zhao P (2011) Diagnosis of colon cancer with fourier transform infrared spectroscopy on the malignant colon tissue samples. Chin Med J 124:2517–2521. https://doi.org/10.3760/cma.j.issn.0366-6999.2011.16.022CrossRefPubMed

53.

Argov S, Ramesh J, Salman A, Sinelnikov I, Goldstein J, Guterman H et al (2002) Diagnostic potential of fourier-transform infrared microspectroscopy and advanced computational methods in colon cancer patients. J Biomed Opt 7:248–254. https://doi.org/10.1117/1.1463051CrossRefPubMed

54.

Depciuch J, Kaznowska E, Zawlik I, Wojnarowska R, Cholewa M, Heraud P et al (2016) Application of raman spectroscopy and infrared spectroscopy in the identification of breast cancer. Appl Spectrosc 70:251–263. https://doi.org/10.1177/0003702815620127CrossRefPubMed

Title: Advances in far-infrared research: therapeutic mechanisms of disease and application in cancer detection
Authors: Jianming Wen
Junrun Pan
Jijie Ma
Xinyang Ge
Zisheng Xu
Xiaolin Wang
Zhong Lv
Publication date: 01-12-2024
Publisher: Springer London
Published in: Lasers in Medical Science / Issue 1/2024
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-024-03994-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Advances in far-infrared research: therapeutic mechanisms of disease and application in cancer detection

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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