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01-12-2023 | Laser | Review Article

Effects of the invasive and non-invasive systemic photobiomodulation using low-level laser in experimental models: A systematic review

Authors: Tainá Caroline dos Santos Malavazzi, Kristianne Porta Santos Fernandes, Talita Christine Camilo Lopez, Maria Fernanda Setubal Destro Rodrigues, Anna Carolina Ratto Tempestini Horliana, Sandra Kalil Bussadori, Raquel Agnelli Mesquita-Ferrari

Published in: Lasers in Medical Science | Issue 1/2023

Abstract

Systemic photobiomodulation (PBM) of the blood or over blood vessels has been associated with bio-stimulating, vasodilating, and anti-inflammatory properties. This treatment modality has been used for modulating inflammatory processes, tissue repair, atherosclerosis, and systemic arterial hypertension, and is described more often in clinical studies than experimental models. Therefore, the aim of the present study was to conduct a literature review regarding the effect of systemic PBM involving the intravascular laser irradiation of blood (ILIB) or non-invasive vascular photobiomodulation (VPBM) using low-level laser (LLL) in experimental (animal) models. The PubMed/MEDLINE®, Scopus, SPIE Digital Library, and Web of Science databases were searched for articles on the use of VPBM with LLL in animal models. Nine original articles met the inclusion criteria and were critically evaluated. The variables of interest were the dosimetric laser parameters, different methods for delivering energy, and the main results. The use laser in the red spectrum was more prevalent and VPBM (non-invasive) predominated over ILIB (invasive). No standardization was found in the dosimetric parameters. However, the studies showed the positive effects of VPBM on arterial pressure and blood circulation, the positive effects of ILIB on blood composition and hematological markers, as well as positive effects of both forms of systemic PBM (ILIB and VPBM) on the tissue repair process. In conclusion, the studies evaluated in the present review showed that the use of systemic PBM with ILIB or non-invasive VPBM induced positive effects, modulating metabolic conditions and tissue repair. However, there is a need for standardization in the dosimetric parameters for the different conditions and processes evaluated using experimental models.

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Chung H, Dai T, Sharma SK et al (2012) The nuts and bolts of low-level laser (Light) therapy. Ann Biomed Eng 40:516–533. https://doi.org/10.1007/s10439-011-0454-7CrossRefPubMed

Arany PR (2016) Craniofacial wound healing with photobiomodulation therapy: new insights and current challenges. J Dent Res 95:977–984. https://doi.org/10.1177/0022034516648939CrossRefPubMed

Hamblin MR (2017) Mechanisms and applications of the anti-inflammatory effects of photobiomodulation. AIMS Biophys 4:337–361. https://doi.org/10.3934/biophy.2017.3.337CrossRefPubMedPubMedCentral

Karu TI (2014) Cellular and molecular mechanisms of photobiomodulation (low-power laser therapy). IEEE J Sel Top Quantum Electron 20:. https://doi.org/10.1109/JSTQE.2013.2273411

de Freitas LF, Hamblin MR (2016) Proposed mechanisms of photobiomodulation or low-level light therapy. 22:348–364. https://doi.org/10.1109/JSTQE.2016.2561201.Proposed

Zein R, Selting W, Hamblin MR (2018) Review of light parameters and photobiomodulation efficacy: dive into complexity. J Biomed Opt 23:1. https://doi.org/10.1117/1.jbo.23.12.120901CrossRefPubMed

de Almeida P, Lopes-Martins RÁB, Tomazoni SS et al (2013) Low-level laser therapy and sodium diclofenac in acute inflammatory response induced by skeletal muscle trauma: effects in muscle morphology and mRNA gene expression of inflammatory markers. Photochem Photobiol 89:501–507. https://doi.org/10.1111/j.1751-1097.2012.01232.xCrossRefPubMed

Souza NHC, Mesquita-Ferrari RA, Rodrigues MFSD, et al (2018) Photobiomodulation and different macrophages phenotypes during muscle tissue repair. J Cell Mol Med 1–13. https://doi.org/10.1111/jcmm.13757

Brito A de, Alves AN, Ribeiro BG, et al (2017) Effect of photobiomodulation on connective tissue remodeling and regeneration of skeletal muscle in elderly rats. Lasers Med Sci 33:9

10.

de Lima Rodrigues D, Alves AN, Guimarães BR, et al (2018) Effect of prior application with and without postinjury treatment with low-level laser on the modulation of key proteins in the muscle repair process. Lasers Med Sci 33:1207–1213. https://doi.org/10.1007/s10103-018-2456-2

11.

Martignago C, Tim CR, Assis L et al (2018) Effect of two laser photobiomodulation application protocols on the viability of random skin flap in rats. Lasers Med Sci 34:1041–1047. https://doi.org/10.1117/12.2289009CrossRefPubMed

12.

Siqueira VPC, Evangelista MIS, dos Santos A et al (2017) Light-Emitting Diode treatment ameliorates allergic lung inflammation in experimental model of asthma induced by ovalbumin. J Biophotonics 10:1683–1693. https://doi.org/10.1002/jbio.201600247CrossRefPubMed

13.

Peron JPS, de Brito AA, Pelatti M et al (2015) Human tubal-derived mesenchymal stromal cells associated with Low level laser therapy significantly reduces Cigarette smoke-induced COPD in C57BL/6 mice. PLoS ONE 10:1–18. https://doi.org/10.1371/journal.pone.0136942CrossRef

14.

Abduch TF, da Silva PAV, de Souza ÁC et al (2020) Evaluation of metalloproteinases-2, -9, and -13 post photobiomodulation in mice talocrural joint. Lasers Med Sci 35:633–640. https://doi.org/10.1007/s10103-019-02860-yCrossRefPubMed

15.

Alves ACA, Albertini R, Dos Santos SA et al (2014) Effect of low-level laser therapy on metalloproteinase MMP-2 and MMP-9 production and percentage of collagen types I and III in a papain cartilage injury model. Lasers Med Sci 29:911–919. https://doi.org/10.1007/s10103-013-1427-xCrossRefPubMed

16.

Andreo L, Ribeiro BG, Alves AN et al (2020) Effects of Photobiomodulation with low‐level laser therapy on muscle repair following a peripheral nerve injury in wistar rats. Photochem Photobiol 96:1124–1132. https://doi.org/10.1111/php.13255

17.

Andreo L, Soldera CA, Ribeiro BG et al (2019) Effects of Photobiomodulation on Functionality in Wistar Rats with Sciatic Nerve Injury. Photochem Photobiol 95:879–885. https://doi.org/10.1111/php.13048

18.

Zeng Y-J, Lin Y-H, Wang Y-C et al (2018) Laser acupuncture-induced analgesic effect and molecular alterations in an incision pain model: a comparison with electroacupuncture-induced effects. Lasers Med Sci 33:295–304. https://doi.org/10.1007/s10103-017-2367-7CrossRefPubMed

19.

Vieira WF, Magalhães SF, Farias FH et al (2019) Raman spectroscopy of dorsal root ganglia from streptozotocin‐induced diabetic neuropathic rats submitted to photobiomodulation therapy. J Biophotonics 12:. https://doi.org/10.1002/jbio.201900135

20.

Tomé RFF, Silva DFB, dos Santos CAO et al (2020) ILIB (intravascular laser irradiation of blood) as an adjuvant therapy in the treatment of patients with chronic systemic diseases—an integrative literature review. Lasers Med Sci 35:1899–1907. https://doi.org/10.1007/s10103-020-03100-4CrossRefPubMed

21.

Yi Wu P, Penn IW, Lin PH et al (2018) Effects of intravenous laser irradiation of blood on pain, function and depression of fibromyalgia patients. Gen Med: Open Access 06. https://doi.org/10.4172/2327-5146.1000310

22.

Kazemikhoo N, Sarafnejad AF, Ansari F, Mehdipour P (2016) Modifying effect of intravenous laser therapy on the protein expression of arginase and epidermal growth factor receptor in type 2 diabetic patients. Lasers Med Sci 31:1537–1545. https://doi.org/10.1007/s10103-016-2012-xCrossRefPubMed

23.

Kazemi Khoo N, Iravani A, Arjmand M et al (2013) A metabolomic study on the effect of intravascular laser blood irradiation on type 2 diabetic patients. Lasers Med Sci 28:1527–1532. https://doi.org/10.1007/s10103-012-1247-4CrossRefPubMed

24.

Moskvin SV (2017) Low-level laser therapy in Russia: History, science and practice. J Lasers Med Sci 8:56–65. https://doi.org/10.15171/jlms.2017.11CrossRefPubMedPubMedCentral

25.

Fernandes KPS, Ferrari RM, Bussadori SK, Franca CM (2021) Vascular photobiomodulation. Photobiomodul Photomed Laser Surg 39:143–144. https://doi.org/10.1089/photob.2020.4965

26.

de Vries RBM, Hooijmans CR, Langendam MW et al (2015) A protocol format for the preparation, registration and publication of systematic reviews of animal intervention studies. Evid Based Preclin Med 2:e00007. https://doi.org/10.1002/ebm2.7CrossRef

27.

Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A (2016) Rayyan-a web and mobile app for systematic reviews. Syst Rev 5:1–10. https://doi.org/10.1186/s13643-016-0384-4CrossRef

28.

Hooijmans CR, Rovers MM, de Vries RBM et al (2014) SYRCLE’s risk of bias tool for animal studies. BMC Med Res Methodol 14:1–9. https://doi.org/10.1186/1471-2288-14-43CrossRef

29.

Amjadi A, Mirmiranpour H, Sobhani SO, Moazami Goudarzi N (2019) Intravenous laser wavelength radiation effect on LCAT, PON1, catalase, and FRAP in diabetic rats. Lasers Med Sci 35:131–138. https://doi.org/10.1007/s10103-019-02805-5CrossRefPubMed

30.

Roshchina AA, Nikolaeva SS, Kozhura VL et al (2003) Water status and LPO in rat tissues during massive blood loss and irradiation with He-Ne laser. Bull Exp Biol Med 135:136–138. https://doi.org/10.1023/A:1023859529038CrossRefPubMed

31.

Komori M, Takada K, Tomizawa Y et al (2009) Microcirculatory responses to acupuncture stimulation and phototherapy. Anesth Analg 108:635–640. https://doi.org/10.1213/ane.0b013e31819317bcCrossRefPubMed

32.

Tanin LV, Petrovsky GG, Tanina RM (1996) Blood-stimulatory and biochemical effects of intravenous laser irradiation of blood with low-active laser radiation in rabbits with peripheral nerve damage. Proc SPIE - Int Soc Opt Eng 2922:406–412. https://doi.org/10.1117/12.260711CrossRef

33.

Tomimura S, Silva BPA, Sanches IC et al (2014) Hemodynamic effect of laser therapy in spontaneously hypertensive rats. Arq Bras Cardiol 161–164. https://doi.org/10.5935/abc.20140117

34.

Lopez TCC, Malavazzi TC dos S, Rodrigues MFSD et al (2022) Histological and biochemical effects of preventive and therapeutic vascular photobiomodulation on rat muscle injury. J Biophotonics 1–12. https://doi.org/10.1002/jbio.202100271

35.

Ramos FS, da Costa Aguiar Alves B, Perez MM et al (2018) The effects of transcutaneous low-level laser therapy on the skin healing process: an experimental model. Lasers Med Sci 33:967–976. https://doi.org/10.1007/s10103-017-2429-xCrossRefPubMed

36.

de Brito Sousa K, Rodrigues MFSD, de Souza Santos D et al (2019) Differential expression of inflammatory and anti-inflammatory mediators by M1 and M2 macrophages after photobiomodulation with red or infrared lasers. Lasers Med Sci 7. https://doi.org/10.1007/s10103-019-02817-1

37.

Chen C-C, Wu Y-T, Su Y-C et al (2019) Efficacy of laser acupuncture for carpal tunnel syndrome. Medicine 98:e16516. https://doi.org/10.1097/md.0000000000016516CrossRefPubMedPubMedCentral

38.

Mikhailov V (2015) The use of Intravenous Laser Blood Irradiation (ILBI) at 630–640 nm to prevent vascular diseases and to increase life expectancy. Laser Ther 24:15–26CrossRef

39.

Anders JJ, Lanzafame RJ, Arany PR (2015) Low-level light/laser therapy versus photobiomodulation therapy. Photomed Laser Surg 33:183–184. https://doi.org/10.1089/pho.2015.9848CrossRefPubMedPubMedCentral

40.

Weber MH, Fußgänger-May T, Wolf T (2007) Die intravasale laserblutbestrahlung - Vorstellung einer neuen therapiemethode. Deutsche Zeitschrift fur Akupunktur 50:12–23. https://doi.org/10.1078/0415-6412-00282CrossRef

41.

Wang H, Deng J, Tu W et al (2016) The hematologic effects of low intensity 650 nm laser irradiation on hypercholesterolemia rabbits. Am J Transl Res 8:2293–2300PubMedPubMedCentral

42.

Martinelli A, Andreo L, Malavazzi TC dos S et al (2022) Vascular photobiomodulation increases muscle fiber diameter and improves the gait during compensatory hypertrophy of plantar muscle in rats. J Biophotonics. https://doi.org/10.1002/jbio.202200192

43.

Yamaikina IV, Mansurov VA, Gorbunova NB et al (2012) Rheology dynamics of the blood and plasma of rats after transdermal laser irradiation of the tail vein in the infrared range. J Eng Phys Thermophys 85:655–661. https://doi.org/10.1007/s10891-012-0698-6CrossRef

Title: Effects of the invasive and non-invasive systemic photobiomodulation using low-level laser in experimental models: A systematic review
Authors: Tainá Caroline dos Santos Malavazzi
Kristianne Porta Santos Fernandes
Talita Christine Camilo Lopez
Maria Fernanda Setubal Destro Rodrigues
Anna Carolina Ratto Tempestini Horliana
Sandra Kalil Bussadori
Raquel Agnelli Mesquita-Ferrari
Publication date: 01-12-2023
Publisher: Springer London
Keyword: Laser
Published in: Lasers in Medical Science / Issue 1/2023
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-023-03799-x

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Effects of the invasive and non-invasive systemic photobiomodulation using low-level laser in experimental models: A systematic review

Abstract

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