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Published in: Lasers in Medical Science 6/2011

01-11-2011 | Original Article

Diabetic distal symmetric polyneuropathy: Effect of low-intensity laser therapy

Authors: Mohammad Ebrahim Khamseh, Nooshafarin Kazemikho, Rokhsareh Aghili, Bijan Forough, Marjan Lajevardi, Fataneh Hashem Dabaghian, Ashrafeddin Goushegir, Mojtaba Malek

Published in: Lasers in Medical Science | Issue 6/2011

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Abstract

Low-intensity laser therapy (LILT) has been considered as a treatment modality in diabetic distal symmetric polyneuropathy (DSP). The aim of this study is to determine the effectiveness of LILT on DSP. We examined 107 subjects with type 2 diabetes for detection of DSP using the Michigan Neuropathy Screening Instrument (MNSI). Seventeen subjects were eligible to be enrolled in the study. Nerve conduction studies (NCS) were performed in all eligible subjects as an objective method to confirm neuropathy. The participants received LILT three times a week for ten sessions. NCSs were reevaluated after completion of the treatment. The absolute changes in NCS parameters were considered to establish the effectiveness of the treatment. Baseline demographics were similar in all participants. The mean differences of NCV parameters were considered for comparison. At the end of the study, the subjects showed a significant increase in neural potential amplitudes (p < 0.05). This study clearly demonstrated a significant positive effect of LILT on improvement of nerve conduction velocity on diabetic distal symmetric polyneuropathy (DSP). This finding supports the therapeutic potential of LILT in DSP.
Literature
1.
go back to reference Dyck PJ, Kratz KM, Karnes JL, Litchy WJ, Klein R, Pach JM, Wilson DM, O’Brien PC, Melton LJr, Service FJ (1993) The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population-based cohort: the Rochester Diabetic Neuropathy Study. Neurology 43(4):817–824PubMed Dyck PJ, Kratz KM, Karnes JL, Litchy WJ, Klein R, Pach JM, Wilson DM, O’Brien PC, Melton LJr, Service FJ (1993) The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population-based cohort: the Rochester Diabetic Neuropathy Study. Neurology 43(4):817–824PubMed
2.
go back to reference Llewelyn JG, Tomlinson DR, Thomas PK (2005) Diabetic neuropathies. In: Dyck PJ, Thomas PK (eds) Peripheral neuropathy, 4th edn. Elsevier, Philadelphia, pp 1951–1992 Llewelyn JG, Tomlinson DR, Thomas PK (2005) Diabetic neuropathies. In: Dyck PJ, Thomas PK (eds) Peripheral neuropathy, 4th edn. Elsevier, Philadelphia, pp 1951–1992
3.
go back to reference Boulton AJ, Vinik AI, Arezzo JC, Bril V, Feldman EL, Freeman R, Malik RA, Maser RE, Sosenko JM, Ziegler D (2005) Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care 28(4):956–962PubMedCrossRef Boulton AJ, Vinik AI, Arezzo JC, Bril V, Feldman EL, Freeman R, Malik RA, Maser RE, Sosenko JM, Ziegler D (2005) Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care 28(4):956–962PubMedCrossRef
4.
go back to reference Davies M, Brophy S, Williams R, Taylor A (2006) The prevalence, severity, and impact of painful diabetic peripheral neuropathy in type 2 diabetes. Diabetes Care 29(7):1518–1522. doi:10.2337/dc05-2228 PubMedCrossRef Davies M, Brophy S, Williams R, Taylor A (2006) The prevalence, severity, and impact of painful diabetic peripheral neuropathy in type 2 diabetes. Diabetes Care 29(7):1518–1522. doi:10.​2337/​dc05-2228 PubMedCrossRef
5.
go back to reference Pfeifer MA, Ross DR, Schrage JP, Gelber DA, Schumer MP, Crain GM, Markwell SJ, Jung S (1993) A highly successful and novel model for treatment of chronic painful diabetic peripheral neuropathy. Diabetes Care 16(8):1103–1115PubMedCrossRef Pfeifer MA, Ross DR, Schrage JP, Gelber DA, Schumer MP, Crain GM, Markwell SJ, Jung S (1993) A highly successful and novel model for treatment of chronic painful diabetic peripheral neuropathy. Diabetes Care 16(8):1103–1115PubMedCrossRef
6.
go back to reference Carrington A, Shaw JE, Van Schie CH, Abbott CA, Vileikyte L, Boulton AJ (2002) Can motor nerve conduction velocity predict foot problems in diabetic subjects over a 6-year outcome period? Diabetes Care 25(11):2010–2015PubMedCrossRef Carrington A, Shaw JE, Van Schie CH, Abbott CA, Vileikyte L, Boulton AJ (2002) Can motor nerve conduction velocity predict foot problems in diabetic subjects over a 6-year outcome period? Diabetes Care 25(11):2010–2015PubMedCrossRef
7.
go back to reference American Diabetes Association (1995) Standardized measures in diabetic neuropathy (Consensus Statement). Diabetes care 18(suppl 1):59–81 American Diabetes Association (1995) Standardized measures in diabetic neuropathy (Consensus Statement). Diabetes care 18(suppl 1):59–81
8.
go back to reference Diabetic polyneuropathy in controlled clinical trials: Consensus Report of the Peripheral Nerve Society (1995). Ann Neurol 38 (3):478–482. doi:10.1002/ana.410380323 Diabetic polyneuropathy in controlled clinical trials: Consensus Report of the Peripheral Nerve Society (1995). Ann Neurol 38 (3):478–482. doi:10.​1002/​ana.​410380323
9.
go back to reference The Capsaicin Study Group (1991) Treatment of painful diabetic neuropathy with topical capsaicin: a multicenter, double-blind, vehicle-controlled study. Arch Intern Med 151:2225–2229CrossRef The Capsaicin Study Group (1991) Treatment of painful diabetic neuropathy with topical capsaicin: a multicenter, double-blind, vehicle-controlled study. Arch Intern Med 151:2225–2229CrossRef
10.
go back to reference Zinman LH, Ngo M, Ng ET, Nwe KT, Gogov S, Bril V (2004) Low-intensity laser therapy for painful symptoms of diabetic sensorimotor polyneuropathy: a controlled trial. Diabetes Care 27(4):921–924PubMedCrossRef Zinman LH, Ngo M, Ng ET, Nwe KT, Gogov S, Bril V (2004) Low-intensity laser therapy for painful symptoms of diabetic sensorimotor polyneuropathy: a controlled trial. Diabetes Care 27(4):921–924PubMedCrossRef
12.
go back to reference Asad A, Hameed MA, Khan UA, Butt MU, Ahmed N, Nadeem A (2009) Comparison of nerve conduction studies with diabetic neuropathy symptom score and diabetic neuropathy examination score in type-2 diabetics for detection of sensorimotor polyneuropathy. J Pak Med Assoc 59(9):594–598PubMed Asad A, Hameed MA, Khan UA, Butt MU, Ahmed N, Nadeem A (2009) Comparison of nerve conduction studies with diabetic neuropathy symptom score and diabetic neuropathy examination score in type-2 diabetics for detection of sensorimotor polyneuropathy. J Pak Med Assoc 59(9):594–598PubMed
13.
go back to reference Vinik AI, Mitchell BD, Leichter SB, Wagner AL, O’Brian JT, Georges LP (1995) Epidemiology of the Complications of Diabetes. In: Leslie RDGRD (ed) Diabetes: Clinical Science in Practice. Cambridge University Press, Cambridge, pp 221–287 Vinik AI, Mitchell BD, Leichter SB, Wagner AL, O’Brian JT, Georges LP (1995) Epidemiology of the Complications of Diabetes. In: Leslie RDGRD (ed) Diabetes: Clinical Science in Practice. Cambridge University Press, Cambridge, pp 221–287
14.
go back to reference Holzer SECA, Martens L, Cuerdon T, Crystal P, Zagari M (1998) Costs and duration of care for lower extremity ulcers in patients with diabetes. Clin Ther 20:169–181PubMedCrossRef Holzer SECA, Martens L, Cuerdon T, Crystal P, Zagari M (1998) Costs and duration of care for lower extremity ulcers in patients with diabetes. Clin Ther 20:169–181PubMedCrossRef
15.
go back to reference Slyke M (2000) Painful peripheral diabetic neuropathy: therapeutic approaches. Consult Pharm 15:544–555 Slyke M (2000) Painful peripheral diabetic neuropathy: therapeutic approaches. Consult Pharm 15:544–555
16.
go back to reference Kannan V (2000) review Molecular mechanisms of diabetic neuropathy. Int J Diab Dev Countries 20:101–103 Kannan V (2000) review Molecular mechanisms of diabetic neuropathy. Int J Diab Dev Countries 20:101–103
19.
go back to reference Hopkins JT, McLoda TA, Seegmiller JG, David Baxter G (2004) Low-level laser therapy facilitates superficial wound healing in humans: a triple-blind, sham-controlled study. J Athl Train 39(3):223–229PubMed Hopkins JT, McLoda TA, Seegmiller JG, David Baxter G (2004) Low-level laser therapy facilitates superficial wound healing in humans: a triple-blind, sham-controlled study. J Athl Train 39(3):223–229PubMed
20.
go back to reference Oron A, Oron U, Streeter J, de Taboada L, Alexandrovich A, Trembovler V, Shohami E (2007) Low-level laser therapy applied transcranially to mice following traumatic brain injury significantly reduces long-term neurological deficits. J Neurotrauma 24(4):651–656. doi:10.1089/neu.2006.0198 PubMedCrossRef Oron A, Oron U, Streeter J, de Taboada L, Alexandrovich A, Trembovler V, Shohami E (2007) Low-level laser therapy applied transcranially to mice following traumatic brain injury significantly reduces long-term neurological deficits. J Neurotrauma 24(4):651–656. doi:10.​1089/​neu.​2006.​0198 PubMedCrossRef
22.
go back to reference Perić Z, Cvetković B (2006) Electrophysiological evaluation of low-intensity laser therapy in patients with diabetic polyneuropathy. FACTA UNIVERSITATIS Series: Medicine and Biology 13(1):11–14 Perić Z, Cvetković B (2006) Electrophysiological evaluation of low-intensity laser therapy in patients with diabetic polyneuropathy. FACTA UNIVERSITATIS Series: Medicine and Biology 13(1):11–14
24.
go back to reference Kreisler MB, Haj HA, Noroozi N, Willershausen B (2004) Efficacy of low-level laser therapy in reducing postoperative pain after endodontic surgery—a randomized double blind clinical study. Int J Oral Maxillofac Surg 33(1):38–41PubMedCrossRef Kreisler MB, Haj HA, Noroozi N, Willershausen B (2004) Efficacy of low-level laser therapy in reducing postoperative pain after endodontic surgery—a randomized double blind clinical study. Int J Oral Maxillofac Surg 33(1):38–41PubMedCrossRef
25.
go back to reference Gur A, Karakoc M, Cevik R, Nas K, Sarac AJ (2003) Efficacy of low-power laser therapy and exercise on pain and functions in chronic low back pain. Lasers Surg Med 32(3):233–238. doi:10.1002/lsm.10134 PubMedCrossRef Gur A, Karakoc M, Cevik R, Nas K, Sarac AJ (2003) Efficacy of low-power laser therapy and exercise on pain and functions in chronic low back pain. Lasers Surg Med 32(3):233–238. doi:10.​1002/​lsm.​10134 PubMedCrossRef
26.
go back to reference Enwemeka CSPJ, Dowdy DS, Harkness EE, Sanford LE, Woodruff LD (2004) The efficacy of low-power lasers in tissue repair and pain control: a meta-analysis study. Photomed Laser Surg 22(4):323–329PubMedCrossRef Enwemeka CSPJ, Dowdy DS, Harkness EE, Sanford LE, Woodruff LD (2004) The efficacy of low-power lasers in tissue repair and pain control: a meta-analysis study. Photomed Laser Surg 22(4):323–329PubMedCrossRef
27.
go back to reference Simunovic Z (1996) Low-level laser therapy with trigger points technique: a clinical study on 243 patients. J Clin Laser Med Surg 14(4):163–167PubMed Simunovic Z (1996) Low-level laser therapy with trigger points technique: a clinical study on 243 patients. J Clin Laser Med Surg 14(4):163–167PubMed
28.
go back to reference Morshedi H (2009) Low-level laser therapy (LLLT) for chronic low back pain (LBP). Eur J Sci Res 29(1):76–81 Morshedi H (2009) Low-level laser therapy (LLLT) for chronic low back pain (LBP). Eur J Sci Res 29(1):76–81
Metadata
Title
Diabetic distal symmetric polyneuropathy: Effect of low-intensity laser therapy
Authors
Mohammad Ebrahim Khamseh
Nooshafarin Kazemikho
Rokhsareh Aghili
Bijan Forough
Marjan Lajevardi
Fataneh Hashem Dabaghian
Ashrafeddin Goushegir
Mojtaba Malek
Publication date
01-11-2011
Publisher
Springer-Verlag
Published in
Lasers in Medical Science / Issue 6/2011
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-011-0977-z

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