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01-12-2005 | Original Article

Dynamic modeling of photothermal interactions for laser-induced interstitial thermotherapy: parameter sensitivity analysis

Authors: S. C. Jiang, X. X. Zhang

Published in: Lasers in Medical Science | Issue 3-4/2005

Abstract

A two-dimensional model was developed to model the effects of dynamic changes in the physical properties on tissue temperature and damage to simulate laser-induced interstitial thermotherapy (LITT) treatment procedures with temperature monitoring. A modified Monte Carlo method was used to simulate photon transport in the tissue in the non-uniform optical property field with the finite volume method used to solve the Pennes bioheat equation to calculate the temperature distribution and the Arrhenius equation used to predict the thermal damage extent. The laser light transport and the heat transfer as well as the damage accumulation were calculated iteratively at each time step. The influences of different laser sources, different applicator sizes, and different irradiation modes on the final damage volume were analyzed to optimize the LITT treatment. The numerical results showed that damage volume was the smallest for the 1,064-nm laser, with much larger, similar damage volumes for the 980- and 850-nm lasers at normal blood perfusion rates. The damage volume was the largest for the 1,064-nm laser with significantly smaller, similar damage volumes for the 980- and 850-nm lasers with temporally interrupted blood perfusion. The numerical results also showed that the variations in applicator sizes, laser powers, heating durations and temperature monitoring ranges significantly affected the shapes and sizes of the thermal damage zones. The shapes and sizes of the thermal damage zones can be optimized by selecting different applicator sizes, laser powers, heating duration times, temperature monitoring ranges, etc.

Bown SG (1983) Phototherapy of tumors. World J Surg 7:700–709CrossRefPubMed

Niemz MH (1999) Translated by Zhang ZX. Laser–tissue interaction. Xi’an Jiaotong University Press, Xi’an, pp 45–67

Roggan A, Müller G (1995) Dosimetry and computer based irradiation planning for laser-induced interstitial thermotherapy (LITT). In: Müller G, Roggan A (eds) Laser-induced interstitial thermotherapy. SPIE Optical Engineering Press, Bellingham, pp. 114–157

Thomson S (1991) Pathologic analysis of photothermal and photomechanical effects of laser–tissue interactions. Photochem Photobiol 53:825–835PubMed

Johnson DE, Price RE, Cromeens DM (1992) Pathologic changes occurring in the prostate following transurethral laser prostatectomy. Lasers Surg Med 12:254–263PubMed

Guiot C, Madon E, Allegro D, Pianta PG, Baiotto B, Gabriele P (1998) Perfusion and thermal field during hyperthermia. Experimental measurements and modeling in recurrent breast cancer. Phys Med Biol 43:2831–2843CrossRefPubMed

Ivarsson K, Olstrud J, Sturesson C, Moller PH, Persson BR, Tranberg KG (1998) Feedback interstitial diode laser (805 nm) thermotherapy system: ex vivo evaluation and mathematical modeling with one and four-fibers. Lasers Surg Med 22:86–96CrossRefPubMed

Lippert BM, Teymoortash A, Folz BJ, Werner JA (2003) Coagulation and temperature distribution in Nd:YAG interstitial laser thermotherapy: an in vitro animal study. Lasers Med Sci 18:19–24CrossRefPubMed

Ismail MS, Philipp C, Torsten U, Weitzel H, Berlien HP (1999) Laser-induced thermotherapy (LITT) for retreatment of locally advanced recurrences of breast cancer. Lasers Med Sci 14:136–142CrossRef

10.

Amin Z, Donald JJ, Masters A, Kant R, Steger A, Bown SG, Lees WR (1993) Hepatic metastasis: interstitial laser photocoagulation with real-time US monitoring and dynamic CT evaluation of the treatment. Radiology 187:339–347PubMed

11.

Minhaj AM, Manns F, Milne PJ, Denham DB, Salas N Jr, Nose I, Damgaard-Iversen K, Parel J-M, Robinson DS (2002) Laser interstitial thermotherapy (LITT) monitoring using high-resolution digital mammography: theory and experimental studies. Phys Med Biol 47:2987–2999CrossRefPubMed

12.

Eyrich GKH, Bruder E, Hilfiker P, Dubno B, Quick HH, Patak MA, Grätz KW, Sailer HF (2000) Temperature mapping of magnetic resonance-guided laser interstitial thermal therapy (LITT) in lymphangiomas of the head and neck. Lasers Surg Med 26:467–476CrossRefPubMed

13.

Atsumi H, Matsumae M, Kaneda M, Muro I, Mamata Y, Komiya T, Tsugu A, Tsugane R (2001) Novel laser system and laser irradiation method reduced the risk of carbonization during laser interstitial thermotherapy: assessed by MR temperature measurement. Lasers Surg Med 29:108–117CrossRefPubMed

14.

McNichols RJ, Gowda A, Kangasniemi M, Bankson JA, Price RE, Hazle JD (2004) MR thermometry-based feedback control of laser interstitial thermal therapy at 980 nm. Lasers Surg Med 34:48–55CrossRefPubMed

15.

Kangasniemi M, McNichols RJ, Bankson JA, Gowda A, Price RE, Hazle JD (2004) Thermal therapy of canine cerebral tumors using a 980 nm diode laser with MR temperature-sensitive imaging feedback. Lasers Surg Med 235:41–50CrossRef

16.

Peters RD, Chan E, Trachtenberg J, Jothy S, Kapusta L, Kucharczyk W, Henkelman RM (2000) Magnetic resonance thermometry for predicting thermal damage: an application of interstitial laser coagulation in an in vivo canine prostate model. Magn Reson Med 44:873–883CrossRefPubMed

17.

Welch AJ (1984) The thermal response of laser irradiated tissue. IEEE J Quantum Electron 20:1471–1481CrossRef

18.

Jacques SL, Prahl SA (1987) Modeling optical and thermal distributions in tissue during laser irradiation. Lasers Surg Med 6:494–503PubMed

19.

Whiting P, Dowden J, Kapadia P (1989) A mathematical analysis of the results of experiments on rats’ livers by local laser hyperthermia. Lasers Med Sci 4:55–64CrossRef

20.

Davis M, Dowden J, Steger A, Kapadia P, Whiting P (1989) A mathematical model for interstitial laser treatment of tumors using four fibers. Lasers Med Sci 4:41–53CrossRef

21.

McKenzie AL (1990) Physics of thermal processes in laser–tissue interaction. Phys Med Biol 35:1175–1209CrossRefPubMed

22.

Sagi A, Shitzer A, Katzir A, Akselrod S (1992) Heating of biological tissue by laser irradiation: theoretical model. Opt Eng 31:1417–1424

23.

Torres JH, Motamedi M, Pearce JA, Welch AJ (1993) Experimental evaluation of mathematical models for predicting the thermal response of tissue to laser irradiation. Appl Opt 32:597–606

24.

Wyman DR, Whelan WM (1994) Basic optothermal diffusion theory for interstitial laser photocoagulation. Med Phys 21:1651–1656CrossRefPubMed

25.

Beacco CM, Mordon SR, Brunetaud JM (1994) Development and experimental in vivo validation of mathematical modeling of laser coagulation. Lasers Surg Med 14:362–373PubMed

26.

Sturesson C, Andersson-Engels S (1995) A mathematical model for predicting the temperature distribution in laser-induced hyperthermia. Experimental evaluation and applications. Phys Med Biol 40:2037–2052

27.

Anvari B, Rastegar S, Motamedi M (1994) Modeling of intraluminal heating of biological tissue: implications for treatment of benign prostatic hyperplasia. IEEE Trans Biomed Eng 41:854–864CrossRefPubMed

28.

Roggan A, Müller G (1994) 2D-computer simulations for real-time irradiation planning of laser induced interstitial thermotherapy (LITT). Proc SPIE 2327:242–251CrossRef

29.

Prapavat V, Roggan A, Walter J, Beuthan J, Klingbeil U, Müller G (1996) In vitro studies and computer simulations to assess the use of a diode laser (850 nm) for laser-induced thermotherapy (LITT). Lasers Surg Med 18:22–33CrossRefPubMed

30.

London RA, Glinsky ME, Zimmerman GB, Bailey DS, Eder DC, Jacques SL (1997) Laser–tissue interaction modeling with LATIS. Appl Opt 36:9068–9074

31.

London RA (1999) Numerical simulation of a diode laser BPH treatment system. Proc SPIE 3601:141–155CrossRef

32.

Ma N, Gao X, Zhang XX (2004) Two-layer simulation model of laser-induced interstitial thermo-therapy. Lasers Med Sci 18:184–189CrossRefPubMed

33.

Ma N, Li HJ, Jiang SC, Zhang XX (2003) A two-layer biological model for laser-induced interstitial thermotherapy (in Chinese). Chin J Lasers 30:380–384

34.

Kim B-M, Jacques SL, Rastegar S, Thomsen S, Motamedi M (1996) Nonlinear finite-element analysis of the role of dynamic changes in blood perfusion and optical properties in laser coagulation of tissue. IEEE J Sel Top Quantum Electron 2:922–933CrossRef

35.

Iizuka MN, Vitkin IA, Kolios MC, Sherar MD (2000) The effects of dynamic optical properties during interstitial laser photocoagulation. Phys Med Biol 45:1335–1357CrossRefPubMed

36.

Wheian WM, Wyman DR (1999) Dynamic modeling of interstitial laser photocoagulation: implications for lesion formation in liver in vivo. Lasers Surg Med 24:202–208CrossRefPubMed

37.

Zhu D, Luo QM, Zhu GM, Liu W (2002) Kinetic thermal response and damage in laser coagulation of tissue. Lasers Surg Med 31:313–321CrossRefPubMed

38.

Jiang SC, Zhang XX (2005) Effects of dynamic changes of tissue properties during laser-induced interstitial thermotherapy (LITT). Lasers Med Sci 19:197–202CrossRefPubMed

39.

Spears JR, James LM, Leonard BM, Sinclair IN, Jenkins RD, Motamedi M, Sinofsky E (1988) Plaque-media rewelding with reversible optical property changes during receptive CW Nd:YAG laser exposure. Lasers Surg Med 8:477–485PubMed

40.

Splinter R, Svenson RH, Littmann L, Tuntelder JR, Chuang CH, Tatsis GP, Thompson M (1991) Optical properties of normal, diseased, and laser photocoagulated myocardium at the Nd:YAG wavelength. Lasers Surg Med 11:117–124PubMed

41.

Jaywant S, Wilson B, Patterson M, Lilge L, Flotte T, Woolsey J, McCulloch C (1993) Temperature dependent changes in the optical absorption and scattering spectra of tissues: correlation with ultrastructure. Proc SPIE 1882:218–229CrossRef

42.

Pickering JW, Posthumus P, van Gemert MJC (1994) Continuous measurement of the heat-induced changes in the optical properties (at 1064 nm) of rat liver. Lasers Surg Med 15:200–205PubMed

43.

Germer CT, Roggan A, Ritz JP, Isbert C, Albrecht D, Müller G, Buhr HJ (1998) Optical properties of native and coagulated human liver tissue and liver metastases in the near infrared range. Lasers Surg Med 23:194–203CrossRefPubMed

44.

Nau WH, Roselli RJ, Milam DF (1999) Measurement of thermal effects on the optical properties of prostate tissue at wavelengths of 1064 and 633 nm. Lasers Surg Med 24:38–47CrossRefPubMed

45.

Ritz JP, Roggan A, Isbert C, Müller G, Buhr HJ, Germer CT (2001) Optical properties of native and coagulated porcine liver tissue between 400 and 2400 nm. Lasers Surg Med 29:205–212CrossRefPubMed

46.

Basu R, Diaz S, Wong BJF, Madsen SJ (2002) Temperature and wavelength dependent scattering of light during slow heating of porcine septal cartilage. Proc SPIE 4617:67–75CrossRef

47.

Duck F (1990) Physical properties of tissue. Academic, London

48.

Welch AJ, van Gemert MJC (1995) Optical–thermal response of laser-irradiated tissue. Plenum Press, New York

49.

Song CW (1984) Effect of local hyperthermia on blood flow and microenvironment: a review. Cancer Res 44:4721s–4730sPubMed

50.

Reinhold H, Endrich B (1986) Tumor microcirculation as a target for hyperthermia. Int J Hyperthermia 2:111–137PubMed

51.

Brown SL, Hunt JW, Hill R (1988) A comparison of the rate of clearance of xenon and pertechnetate ion in murine tumors and normal leg muscles. Nucl Med Biol 15:381–390

52.

Salcman M, Moriyama E, Elsner HJ, Rossman H, Gettleman RA, Neuberth G, Corradino G (1989) Cerebral blood flow and the thermal properties of the brain: a preliminary analysis. J Neurosurg 70:592–598PubMed

53.

Aggarwal SJ, Da Costa R, Diller KR, Hinich MJ (1990) The effects of burn injury on vasoactivity in hamster peripheral microcirculation. Microvasc Res 40:73–87CrossRefPubMed

54.

Lynn B, Cotsell B (1991) The delay in onset of vasodilator flare in human skin at increasing distances from a localized noxious stimulus. Microvasc Res 41:197–202CrossRefPubMed

55.

Fahim MA, El-Sabban F (1995) Hyperthermia induces ultrastructural changes in mouse pial microvessels. Anat Rec 242:77–82CrossRefPubMed

56.

Mordon S, Desmettre T, Devoisselle JM, Soulie S (1997) Thermal damage assessment of blood vessels in a hamster skin flap model by fluorescence measurement of a liposome-dye system. Lasers Surg Med 20:131–141CrossRefPubMed

57.

Barton JK, Popok DP, Black JF (2001) Thermal analysis of blood undergoing laser photocoagulation. IEEE J Sel Top Quantum Electron 7:936–943CrossRef

58.

Flock ST, Patterson MS, Wilson BC, Wyman DR (1989) Monte Carlo Modeling of light propagation in highly scattering tissues-I: model predictions and comparison with diffusion theory. IEEE Trans Biomed Eng 36:1162–1168CrossRefPubMed

59.

Henyey LG, Greenstein JL (1941) Diffuse radiation in the galaxy. Astrophys J 93:70–83CrossRef

60.

Wang LH, Jacques SL, Zheng LQ (1995) MCML—Monte Carlo modeling of light transport in multi-layered tissue. Comput Methods Programs Biomed 47:131–146CrossRefPubMed

61.

Jode ML (2000) Monte Carlo simulations of light distributions in an embedded tumor model: studies of selectivity in photodynamic therapy. Lasers Med Sci 15:49–56CrossRef

62.

Pfefer TJ, Barton JK, Chan EK, Ducros MG, Sorg BS, Milner TE, Nelson JS, Welch AJ A three-dimensional modular adaptable grid numerical model for light propagation during laser irradiation of skin tissue. IEEE J Sel Top Quantum Electron 2:934–942

63.

Charny CK (1992) Mathematical models of bioheat transfer. In: Hartnett JP, Irvine TF, Cho YI (eds) Advances in heat transfer. Academic, New York, pp 19–155

64.

Arkin H, Xu LX, Holmes KR (1994) Recent developments in modeling heat transfer in blood perfused tissues. IEEE Trans Biomed Eng 41:97–107CrossRefPubMed

65.

Pennes HH (1948) Analysis of tissue and arterial blood temperatures in resting human forearm. J Appl Physiol 1:93–122

66.

Tao WQ (2001) Numerical heat transfer (in Chinese). Xi’an Jiaotong University Press, Xi’an

67.

Henriques FC Jr (1947) Studies of thermal injuries. V. The predictability and the significance of thermally induced rate processes leading to irreversible epidermal injury. Arch Pathol 43:489–502

68.

Sapareto SA, Dewey WC (1984) Thermal dose determination in cancer therapy. Int J Radiat Oncol Biol Phys 10:787–800PubMed

69.

Albrecht D, Germer CT, Isbert C, Ritz JP, Roggan A, Müller G, Buhr HJ (1998) Interstitial laser coagulation: evaluation of the effect of normal liver blood perfusion and the application mode on lesion size. Lasers Surg Med 23:40–47CrossRefPubMed

70.

Heisterkamp J, van Hillegersberg R, Sinofsky EL, IJzermans JNM (1999) Interstitial laser photocoagulation with four cylindrical diffusing fiber tips: importance of mutual fiber distance. Lasers Med Sci 14:216–220CrossRef

Title: Dynamic modeling of photothermal interactions for laser-induced interstitial thermotherapy: parameter sensitivity analysis
Authors: S. C. Jiang
X. X. Zhang
Publication date: 01-12-2005
Publisher: Springer-Verlag
Published in: Lasers in Medical Science / Issue 3-4/2005
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-005-0359-5

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Dynamic modeling of photothermal interactions for laser-induced interstitial thermotherapy: parameter sensitivity analysis

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