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01-04-2022 | Mood Disorders | Brief Communication

Plasma neurofilament light chain levels are associated with depressive and anxiety symptoms in Parkinson’s disease

Authors: Weifang Yin, Yongyun Zhu, Baiyuan Yang, Fang Wang, Kangfu Yin, Chuanbin Zhou, Hui Ren, Xinglong Yang

Published in: Neurological Sciences | Issue 4/2022

Abstract

The present study aimed to explore the association of plasma neurofilament light chain (NfL) levels with depression and anxiety in Parkinson’s disease (PD). This prospective study enrolled 116 patients with PD and 38 healthy controls, and found plasma NfL levels were higher in patients with depression or anxiety than in those without these symptoms. Binary logistic regression identified NfL concentration as an independent predictor of depression and anxiety in PD. In conclusion, elevated plasma NfL may be associated with severity of depression and anxiety in PD patients and may serve as a diagnostic biomarker of PD with moderate to severe depression or anxiety.

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Title: Plasma neurofilament light chain levels are associated with depressive and anxiety symptoms in Parkinson’s disease
Authors: Weifang Yin
Yongyun Zhu
Baiyuan Yang
Fang Wang
Kangfu Yin
Chuanbin Zhou
Hui Ren
Xinglong Yang
Publication date: 01-04-2022
Publisher: Springer International Publishing
Keywords: Mood Disorders
Affective Disorder
Parkinson's Disease
Anxiety
Published in: Neurological Sciences / Issue 4/2022
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-022-05914-2

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Plasma neurofilament light chain levels are associated with depressive and anxiety symptoms in Parkinson’s disease

Abstract

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Abstract

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