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Neurological Sciences

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Open Access 01-12-2019 | Stroke | Review Article

Influences of genetic variants on stroke recovery: a meta-analysis of the 31,895 cases

Authors: Nikhil Math, Thang S. Han, Irina Lubomirova, Robert Hill, Paul Bentley, Pankaj Sharma

Published in: Neurological Sciences | Issue 12/2019

Abstract

Background

The influences of genetic variants on functional clinical outcomes following stroke are unclear. In order to reliably quantify these influences, we undertook a comprehensive meta-analysis of outcomes after acute intracerebral haemorrhage (ICH) or ischaemic stroke (AIS) in relation to different genetic variants.

Methods

PubMed, PsycInfo, Embase and Medline electronic databases were searched up to January 2019. Outcomes, defined as favourable or poor, were assessed by validated scales (Barthel index, modified Rankin scale, Glasgow outcome scale and National Institutes of Health stroke scale).

Results

Ninety-two publications comprising 31,895 cases met our inclusion criteria. Poor outcome was observed in patients with ICH who possessed the APOE4 allele: OR =2.60 (95% CI = 1.25–5.41, p = 0.01) and in AIS patients with the GA or AA variant at the BDNF-196 locus: OR = 2.60 (95% CI = 1.25–5.41, p = 0.01) or a loss of function allele of CYP2C19: OR = 2.36 (95% CI = 1.56–3.55, p < 0.0001). Poor outcome was not associated with APOE4: OR = 1.02 (95% CI = 0.81–1.27, p = 0.90) or IL6-174 G/C: OR = 2.21 (95% CI = 0.55–8.86, p = 0.26) in patients with AIS.

Conclusions

We demonstrate that recovery of AIS was unfavourably associated with variants of BDNF and CYP2C19 genes whilst recovery of ICH was unfavourably associated with APOE4 gene.

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Title: Influences of genetic variants on stroke recovery: a meta-analysis of the 31,895 cases
Authors: Nikhil Math
Thang S. Han
Irina Lubomirova
Robert Hill
Paul Bentley
Pankaj Sharma
Publication date: 01-12-2019
Publisher: Springer International Publishing
Keyword: Stroke
Published in: Neurological Sciences / Issue 12/2019
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-019-04024-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Influences of genetic variants on stroke recovery: a meta-analysis of the 31,895 cases

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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