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Neurological Sciences

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01-09-2019 | Stroke | Original Article

Temporal dynamics of peripheral neutrophil and lymphocytes following acute ischemic stroke

Authors: Ashley B. Petrone, Rhae D. Eisenman, Kelsey N. Steele, Lindsey T. Mosmiller, Ogaga Urhie, Matthew J. Zdilla

Published in: Neurological Sciences | Issue 9/2019

Abstract

Background

The immune response to acute ischemic stroke (AIS) is implicated in diagnosis, prognosis, and intervention; however, the temporal dynamics of leukocytes following AIS are poorly understood. The purpose of this study was to characterize peripheral leukocyte dynamics following AIS among individuals with poor and favorable outcomes.

Methods

A retrospective chart review was conducted among patients with a diagnosis of AIS who were treated at a comprehensive stroke center across a 3-year timeframe. Groups were defined according to stroke outcomes. Patients with poor outcomes were distinguished from those with favorable outcomes by discharge National Institute of Health Stroke Score, infarct size, and Modified Rankin Scale. Leukocyte counts were compared among controls and AIS outcome groups.

Results

The neutrophil-lymphocyte ratio (NLR) calculated at 48–72 h post-AIS was identified as the strongest predictor of outcome. NLR was significantly higher in the poor outcome group (8.68 ± 0.93) compared with both the favorable outcome (4.5 ± 0.51, p = 0.009) and control group (4.33 ± 0.66, p < 0.001). Patients with a 48–72 h NLR ≥ 4.58 were 5.58 times more likely to have a poor outcome than AIS patients with an NLR < 4.58.

Conclusions

The results of this study improve the understanding of the immune response in AIS. Low neutrophil count relative to high lymphocyte count at 48–72 h post-AIS should be considered a predictor of a favorable stroke outcome. Conversely, high neutrophil count relative to low lymphocyte count at 48–72 h post-AIS should be considered a predictor of a poor stroke outcome.

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Title: Temporal dynamics of peripheral neutrophil and lymphocytes following acute ischemic stroke
Authors: Ashley B. Petrone
Rhae D. Eisenman
Kelsey N. Steele
Lindsey T. Mosmiller
Ogaga Urhie
Matthew J. Zdilla
Publication date: 01-09-2019
Publisher: Springer International Publishing
Keyword: Stroke
Published in: Neurological Sciences / Issue 9/2019
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-019-03919-y

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Temporal dynamics of peripheral neutrophil and lymphocytes following acute ischemic stroke

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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