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01-02-2019 | Original Article

Lack of association between dopamine transporter loss and non-motor symptoms in patients with Parkinson’s disease: a detailed PET analysis of 12 striatal subregions

Authors: Soo Bin Park, Kyum-Yil Kwon, Jeong-Yoon Lee, Kayeong Im, Jun-Sang Sunwoo, Kyung Bok Lee, Hakjae Roh, Moo-Young Ahn, Suyeon Park, Soo-Jong Kim, Jungsu S. Oh, Jae Seung Kim

Published in: Neurological Sciences | Issue 2/2019

Abstract

Introduction

Patients with Parkinson’s disease (PD) present a variety of non-motor symptoms. However, it remains unclear whether dopamine depletion is related to non-motor symptoms, and which non-motor symptoms are significantly dependent on dopaminergic deficit.

Methods

Forty-one patients with PD who underwent positron emission tomography imaging of dopamine transporters (DATs) were recruited for this study. The striatum was divided into 12 subregions, and DAT activity, as striatal dopaminergic concentration, was calculated in each subregion. In addition to measuring motor symptoms using the Unified Parkinson’s Disease Rating Scale-part III (UPDRS-III), various non-motor symptoms were assessed using the Montreal cognitive assessment, frontal assessment battery, Beck depression inventory (BDI), Beck anxiety inventory, PD sleep scale (PDSS), PD fatigue scale, and non-motor symptoms scale (NMSS) for PD.

Results

For simple linear regression analyses, dopaminergic depletion in all striatal subregions was negatively correlated with the UPDRS-III score. The most relevant non-motor symptom assessment related to dopaminergic loss in the 12 subregions was NMSS, followed by BDI and PDSS. However, following multiple linear regression analyses, dopaminergic depletion in the 12 striatal subregions was not related with any of the non-motor symptoms. Conversely, dopaminergic deficit in the right anterior and posterior putamen was associated with the UPDRS-III score.

Conclusions

Striatal dopaminergic depletion was not significantly correlated with any of the various non-motor symptoms in PD. Our findings suggest that non-dopaminergic systems are significantly implicated in the pathogenesis of non-motor symptoms in patients with PD.

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Title: Lack of association between dopamine transporter loss and non-motor symptoms in patients with Parkinson’s disease: a detailed PET analysis of 12 striatal subregions
Authors: Soo Bin Park
Kyum-Yil Kwon
Jeong-Yoon Lee
Kayeong Im
Jun-Sang Sunwoo
Kyung Bok Lee
Hakjae Roh
Moo-Young Ahn
Suyeon Park
Soo-Jong Kim
Jungsu S. Oh
Jae Seung Kim
Publication date: 01-02-2019
Publisher: Springer International Publishing
Published in: Neurological Sciences / Issue 2/2019
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-018-3632-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Lack of association between dopamine transporter loss and non-motor symptoms in patients with Parkinson’s disease: a detailed PET analysis of 12 striatal subregions

Abstract

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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