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01-12-2018 | Original Article

An updated analysis with 45,078 subjects confirms the association between SNCA rs11931074 and Parkinson’s disease

Authors: Xu Liu, Ruixia Zhu, Tongling Xiao, Qu Li, Ying Zhu, Zhiyi He

Published in: Neurological Sciences | Issue 12/2018

Abstract

Large-scale genome-wide association study (GWAS) has identified that the alpha-synuclein (SNCA) rs11931074 polymorphism is associated with Parkinson’s disease (PD) susceptibility in individuals of Japanese descent. Subsequently, a number of replication studies have been performed in Asian and Caucasian populations. However, the results remain controversial due to the relatively small sample sizes and genetic heterogeneity. Here, to overcome the limitations of individual studies, we reevaluated this association with data from 33 independent studies involving 15,368 patients and 29,710 control samples identified by searching PubMed and EMBase databases. Odds ratios (OR) with 95% confidence interval (CI) were applied to assess the association between SNCA rs11931074 polymorphism and PD. Heterogeneity, sensitivity analysis, and publication bias were conducted to measure the robustness of our findings. Using allele, recessive, dominant, and additive models, we did not reveal significant heterogeneity among 33 studies. Significant association of the SNCA rs11931074 polymorphism with PD was observed (T vs. G: OR = 1.36, 95% CI = 1.31–1.42; TT vs. TG + GG: OR = 1.58, 95% CI = 1.46–1.72; TT + TG vs. GG: OR = 1.44, 95% CI = 1.35–1.55; TT vs. GG: OR = 1.87, 95% CI = 1.68–2.09) in the pooled populations. Furthermore, subgroup analyses accounting for ethnicity found similar significant results in both Asian and Caucasian populations. In conclusion, our meta-analysis further indicates that the SNCA rs11931074 polymorphism contributes to PD susceptibility. We believe that our findings will be very useful for future genetic studies on PD.

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Title: An updated analysis with 45,078 subjects confirms the association between SNCA rs11931074 and Parkinson’s disease
Authors: Xu Liu
Ruixia Zhu
Tongling Xiao
Qu Li
Ying Zhu
Zhiyi He
Publication date: 01-12-2018
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 12/2018
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-018-3538-4

Keynote webinar | Spotlight on medication adherence

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An updated analysis with 45,078 subjects confirms the association between SNCA rs11931074 and Parkinson’s disease

Abstract

Keynote webinar | Spotlight on medication adherence

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Abstract

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