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Published in: Neurological Sciences 1/2018

01-06-2018 | Review Article

Pain in optic neuropathies

Authors: Stefania Bianchi Marzoli, Alessandra Criscuoli

Published in: Neurological Sciences | Special Issue 1/2018

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Abstract

Pain occurs with optic neuropathies associated with inflammatory central nervous system diseases (MS and NMO), idiopathic intracranial hypertension and spontaneous hypotension, giant cell arteritis, immunomediated systemic diseases, compressive lesions, or infective disorders. Pain can precede the onset of visual loss in acute optic neuritis, it can be irradiated to the orbital region in giant cell arteritis and parasellar compressive optic neuropathies, or it may be located to the back of the eye with posterior scleritis. History of symptoms together with complete neuro-ophthalmological examination must guide the differential diagnosis and neuroimaging. Painful visual loss due to different pathophysiological mechanisms requires specific treatment and prognosis.
Literature
1.
go back to reference Bianchi Marzoli S, Criscuoli A (2015) Headaches attributed to visual disturbances. Neurol Sci 36(Suppl 1):85–88PubMedCrossRef Bianchi Marzoli S, Criscuoli A (2015) Headaches attributed to visual disturbances. Neurol Sci 36(Suppl 1):85–88PubMedCrossRef
4.
go back to reference Agostoni E, Frigerio R, Protti A (2005) Controversies in optic neuritis pain diagnosis. Neurol Sci 26(Suppl 2):75–78CrossRef Agostoni E, Frigerio R, Protti A (2005) Controversies in optic neuritis pain diagnosis. Neurol Sci 26(Suppl 2):75–78CrossRef
5.
go back to reference Fazzone HE, Lefton DR, Kupersmith MJ (2003) Optic neuritis: correlation of pain and magnetic resonance imaging. Ophthalmology 110(8):1646–1649PubMedCrossRef Fazzone HE, Lefton DR, Kupersmith MJ (2003) Optic neuritis: correlation of pain and magnetic resonance imaging. Ophthalmology 110(8):1646–1649PubMedCrossRef
6.
go back to reference Biousse V, Newman NJ (2017) Diagnosis and classification of optic neuropathies. Lancet Neurol 16(5):343–344PubMedCrossRef Biousse V, Newman NJ (2017) Diagnosis and classification of optic neuropathies. Lancet Neurol 16(5):343–344PubMedCrossRef
7.
go back to reference Truini A, Barbanti P, Pozzilli C, Cruccu G (2013) A mechanism-based classification of pain in multiple sclerosis. J Neurol 260:351–367PubMedCrossRef Truini A, Barbanti P, Pozzilli C, Cruccu G (2013) A mechanism-based classification of pain in multiple sclerosis. J Neurol 260:351–367PubMedCrossRef
9.
go back to reference Guy J, Mao J, Bidgood WD Jr, Mancuso A, Quisling RG (1992) Enhancement and demyelination of the intraorbital optic nerve. Fat suppression magnetic resonance imaging. Ophthalmology 99(5):713–719PubMedCrossRef Guy J, Mao J, Bidgood WD Jr, Mancuso A, Quisling RG (1992) Enhancement and demyelination of the intraorbital optic nerve. Fat suppression magnetic resonance imaging. Ophthalmology 99(5):713–719PubMedCrossRef
10.
go back to reference Kupersmith MJ, Alban T, Zeiffer B, Lefton D (2002) Contrast-enhanced MRI in acute optic neuritis: relationship to visual performance. Brain 125(4):812–822PubMedCrossRef Kupersmith MJ, Alban T, Zeiffer B, Lefton D (2002) Contrast-enhanced MRI in acute optic neuritis: relationship to visual performance. Brain 125(4):812–822PubMedCrossRef
11.
go back to reference Bradl M, Kanamori Y, Nakashima I, Misu T, Fujihara K, Lassmann H, Sandkühler J (2014) Pain in neuromyelitis optica—prevalence, pathogenesis and therapy. Nat Rev Neurol 10(9):529–536PubMedCrossRef Bradl M, Kanamori Y, Nakashima I, Misu T, Fujihara K, Lassmann H, Sandkühler J (2014) Pain in neuromyelitis optica—prevalence, pathogenesis and therapy. Nat Rev Neurol 10(9):529–536PubMedCrossRef
12.
13.
go back to reference Sammut SJ, Kandasamy J, Newman W, Sinha A, Ross J, Blair JC, May P (2008) Relief of severe retro-orbital pain and vision improvement after optic-nerve decompression in polyostotic fibrous dysplasia: case report and review of the literature. Childs Nerv Syst 24(4):515–520PubMedCrossRef Sammut SJ, Kandasamy J, Newman W, Sinha A, Ross J, Blair JC, May P (2008) Relief of severe retro-orbital pain and vision improvement after optic-nerve decompression in polyostotic fibrous dysplasia: case report and review of the literature. Childs Nerv Syst 24(4):515–520PubMedCrossRef
14.
go back to reference Qian P, Lancia S, Alvarez E, Klawiter E, Cross A, Naismith R (2012) Association of neuromyelitis optica with severe and intractable pain. Arch Neurol 69(11):1482–1487PubMedPubMedCentralCrossRef Qian P, Lancia S, Alvarez E, Klawiter E, Cross A, Naismith R (2012) Association of neuromyelitis optica with severe and intractable pain. Arch Neurol 69(11):1482–1487PubMedPubMedCentralCrossRef
15.
17.
go back to reference Lin YC, Wang AG, Yen MY (2009) Systemic lupus erythematosus-associated optic neuritis: clinical experience and literature review. Acta Ophthalmol 87(2):204–210PubMedCrossRef Lin YC, Wang AG, Yen MY (2009) Systemic lupus erythematosus-associated optic neuritis: clinical experience and literature review. Acta Ophthalmol 87(2):204–210PubMedCrossRef
18.
go back to reference Chaudhry I, Al-Obaisi S, Al-Sheikh O, Galvez A (2012) Unilateral optic neuritis, scleritis and exudative retinal detachment due to recurrent orbital pseudotumor. Saudi J Ophthalmol 26:449–451PubMedPubMedCentralCrossRef Chaudhry I, Al-Obaisi S, Al-Sheikh O, Galvez A (2012) Unilateral optic neuritis, scleritis and exudative retinal detachment due to recurrent orbital pseudotumor. Saudi J Ophthalmol 26:449–451PubMedPubMedCentralCrossRef
19.
go back to reference Ohtsuka K, Hashimoto M, Miura M, Nakamura Y (1997) Posterior scleritis with optic perineuritis and internal ophthalmoplegia. Br J Ophthalmol 81:513–517PubMedCentralCrossRef Ohtsuka K, Hashimoto M, Miura M, Nakamura Y (1997) Posterior scleritis with optic perineuritis and internal ophthalmoplegia. Br J Ophthalmol 81:513–517PubMedCentralCrossRef
20.
go back to reference Randhawa S, Van Stavern GP (2008) Idiopathic intracranial hypertension (pseudotumor cerebri). Curr Opin Ophthalmol 19(6):445–453PubMedCrossRef Randhawa S, Van Stavern GP (2008) Idiopathic intracranial hypertension (pseudotumor cerebri). Curr Opin Ophthalmol 19(6):445–453PubMedCrossRef
22.
go back to reference D’Amico D, Curone M, Ciasca P, Cammarata G, Melzi L, Bussone G, Bianchi Marzoli S (2013) Headache prevalence and clinical features in patients with idiopathic intracranial hypertension (IIH). Neurol Sci 34(Suppl 1):147–149CrossRef D’Amico D, Curone M, Ciasca P, Cammarata G, Melzi L, Bussone G, Bianchi Marzoli S (2013) Headache prevalence and clinical features in patients with idiopathic intracranial hypertension (IIH). Neurol Sci 34(Suppl 1):147–149CrossRef
23.
24.
go back to reference Goksel BK, Yildirim T, Sizmaz S, Reyhan M, Karatas M (2012) Optic neuropathy associated with spontaneous intracranial hypotension. Acta Neurol Belg 112(4):361–365PubMedCrossRef Goksel BK, Yildirim T, Sizmaz S, Reyhan M, Karatas M (2012) Optic neuropathy associated with spontaneous intracranial hypotension. Acta Neurol Belg 112(4):361–365PubMedCrossRef
25.
go back to reference Adesina O, McNally SK, Katz B, Warner J, McFadden M, Digre K (2017) Diffusion-weighted imaging and post-contrast enhancement in differentiating optic neuritis and non-arteritic anterior optic neuropathy. Neuro-Ophthalmology 13:1–9 Adesina O, McNally SK, Katz B, Warner J, McFadden M, Digre K (2017) Diffusion-weighted imaging and post-contrast enhancement in differentiating optic neuritis and non-arteritic anterior optic neuropathy. Neuro-Ophthalmology 13:1–9
26.
go back to reference Blandford A, Zhang D, Chundury R, Perry J (2017) Dysthyroid optic neuropathy: update on pathogenesis, diagnosis, and management. Expert Rev Ophthalmol 12(2):111–121PubMedPubMedCentralCrossRef Blandford A, Zhang D, Chundury R, Perry J (2017) Dysthyroid optic neuropathy: update on pathogenesis, diagnosis, and management. Expert Rev Ophthalmol 12(2):111–121PubMedPubMedCentralCrossRef
27.
go back to reference Kan E, Kan EK, Ecemis G, Colak R (2014) Presence of thyroid-associated ophthalmopathy in Hashimoto’s thyroiditis. Int J Ophth 18 7(4):644–647 Kan E, Kan EK, Ecemis G, Colak R (2014) Presence of thyroid-associated ophthalmopathy in Hashimoto’s thyroiditis. Int J Ophth 18 7(4):644–647
28.
go back to reference Bartalena L (2015) Sight-threatening Graves’ orbitopathy. In: de Groot LJ, Chrousos G, Dungan K, Feingold KR, Grossman A, Hershman JM, Koch C, Korbonits M, McLachlan R, New M, Purnell J, Rebar R, Singer F, Vinik A (eds). South Dartmouth (MA), MDText.com, Inc; Apr 12 Bartalena L (2015) Sight-threatening Graves’ orbitopathy. In: de Groot LJ, Chrousos G, Dungan K, Feingold KR, Grossman A, Hershman JM, Koch C, Korbonits M, McLachlan R, New M, Purnell J, Rebar R, Singer F, Vinik A (eds). South Dartmouth (MA), MDText.com, Inc; Apr 12
29.
go back to reference Politi LS, Godi C, Cammarata G, Ambrosi A, Iadanza A, Lanzi R, Falini A, Bianchi Marzoli S (2014) Magnetic resonance imaging with diffusion-weighted imaging in the evaluation of thyroid-associated orbitopathy: getting below the tip of the iceberg. Eur Radiol 24 (5):1118–1126PubMedCrossRef Politi LS, Godi C, Cammarata G, Ambrosi A, Iadanza A, Lanzi R, Falini A, Bianchi Marzoli S (2014) Magnetic resonance imaging with diffusion-weighted imaging in the evaluation of thyroid-associated orbitopathy: getting below the tip of the iceberg. Eur Radiol 24 (5):1118–1126PubMedCrossRef
30.
go back to reference Yilmaz SG, Ture G, Zengin MÖ, Talay E, Men S (2015) Optic nerve and dura mater involvement as the first sign of multiple myeloma. Eur J Ophthalmol 25(1):77–79PubMedCrossRef Yilmaz SG, Ture G, Zengin MÖ, Talay E, Men S (2015) Optic nerve and dura mater involvement as the first sign of multiple myeloma. Eur J Ophthalmol 25(1):77–79PubMedCrossRef
32.
go back to reference Siddiqui S, Kinshuck AJ, Srinivasan VR (2013) Orbital apex syndrome secondary to granulomatosis with polyangiitis. BMJ Case Rep Siddiqui S, Kinshuck AJ, Srinivasan VR (2013) Orbital apex syndrome secondary to granulomatosis with polyangiitis. BMJ Case Rep
34.
go back to reference Alroughani R, Behbehani (2016) Optic nerve sheath meningioma masquerading as optic neuritis. Case Rep Neurol Med 2016 Alroughani R, Behbehani (2016) Optic nerve sheath meningioma masquerading as optic neuritis. Case Rep Neurol Med 2016
Metadata
Title
Pain in optic neuropathies
Authors
Stefania Bianchi Marzoli
Alessandra Criscuoli
Publication date
01-06-2018
Publisher
Springer International Publishing
Published in
Neurological Sciences / Issue Special Issue 1/2018
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-018-3334-1

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