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01-10-2017 | Guideline Article

Cerebrospinal fluid analysis and the determination of oligoclonal bands

Authors: Matteo Gastaldi, Elisabetta Zardini, Rosaria Leante, Maddalena Ruggieri, Gianna Costa, Eleonora Cocco, Giovanna De Luca, Ivana Cataldo, Tiziana Biagioli, Clara Ballerini, Massimiliano Castellazzi, Enrico Fainardi, Paola Pettini, Mauro Zaffaroni, Debora Giunti, Elisabetta Capello, Gaetano Bernardi, Emilio Ciusani, Claudia Giannotta, Eduardo Nobile-Orazio, Elena Bazzigaluppi, Gabriella Passerini, Roberta Bedin, Patrizia Sola, Rinaldo Brivio, Guido Cavaletti, Arianna Sala, Antonio Bertolotto, Gaetano Desina, Maurizio A. Leone, Sara Mariotto, Sergio Ferrari, Andreina Paternoster, Davide Giavarina, Francesco Lolli, Diego Franciotta

Published in: Neurological Sciences | Special Issue 2/2017

Abstract

This document presents the guidelines for the cerebrospinal fluid (CSF) analysis and the determination of oligoclonal bands (OCBs) as pivotal tests in neuroinflammatory pathologies of the central nervous system. The guidelines have been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian Association of Neuroimmunology (AINI) congresses. Essential clinical information on the pathologies in which the CSF analysis is indicated, and, particularly, on those characterized by the presence of OCBs in the intrathecal compartment, indications and limits of CSF analysis and OCB determination, instructions for result interpretation, and agreed laboratory protocols (Appendix) are reported for the communicative community of neurologists and clinical pathologists.

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Title: Cerebrospinal fluid analysis and the determination of oligoclonal bands
Authors: Matteo Gastaldi
Elisabetta Zardini
Rosaria Leante
Maddalena Ruggieri
Gianna Costa
Eleonora Cocco
Giovanna De Luca
Ivana Cataldo
Tiziana Biagioli
Clara Ballerini
Massimiliano Castellazzi
Enrico Fainardi
Paola Pettini
Mauro Zaffaroni
Debora Giunti
Elisabetta Capello
Gaetano Bernardi
Emilio Ciusani
Claudia Giannotta
Eduardo Nobile-Orazio
Elena Bazzigaluppi
Gabriella Passerini
Roberta Bedin
Patrizia Sola
Rinaldo Brivio
Guido Cavaletti
Arianna Sala
Antonio Bertolotto
Gaetano Desina
Maurizio A. Leone
Sara Mariotto
Sergio Ferrari
Andreina Paternoster
Davide Giavarina
Francesco Lolli
Diego Franciotta
Publication date: 01-10-2017
Publisher: Springer Milan
Published in: Neurological Sciences / Issue Special Issue 2/2017
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-017-3034-2

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Cerebrospinal fluid analysis and the determination of oligoclonal bands

Abstract

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