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01-05-2017 | NEUROBIOLOGY OF HEADACHE

The role of anti-CGRP antibodies in the pathophysiology of primary headaches

Authors: Piero Barbanti, Cinzia Aurilia, Luisa Fofi, Gabriella Egeo, Patrizia Ferroni

Published in: Neurological Sciences | Special Issue 1/2017

Abstract

Calcitonin gene-related peptide (CGRP), a potent vasodilator and pain-signaling neuropeptide, is a validated therapeutic target for migraine and cluster headache. Four anti-CGRP monoclonal antibodies (mAbs) have been developed, representing the first specific, mechanism-based, migraine prophylactic treatment. CGRP mAbs demonstrated good efficacy coupled to excellent tolerability and safety in 5 phase II clinical trials. Notably, CGRP mAbs induced complete migraine remission in a patients’ subset. To date, more than 20 phase III trials using CGRP mAbs for of episodic and chronic migraine and cluster headache prevention are ongoing. Future investigations will shed light on migraine endophenotypes predictive of good CGRP mAbs responsiveness and provide answers on their long-term cardiovascular safety.

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Title: The role of anti-CGRP antibodies in the pathophysiology of primary headaches
Authors: Piero Barbanti
Cinzia Aurilia
Luisa Fofi
Gabriella Egeo
Patrizia Ferroni
Publication date: 01-05-2017
Publisher: Springer Milan
Published in: Neurological Sciences / Issue Special Issue 1/2017
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-017-2907-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The role of anti-CGRP antibodies in the pathophysiology of primary headaches

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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