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Published in: Neurological Sciences 10/2015

01-10-2015 | Original Article

TREM2 variants and risk of Alzheimer’s disease: a meta-analysis

Authors: Yanjun Lu, Wei Liu, Xiong Wang

Published in: Neurological Sciences | Issue 10/2015

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Abstract

Recent studies show that heterozygous variant of triggering receptor expressed on myeloid cells 2 (TREM2) increase the risk of Alzheimer’s disease (AD) but with inconclusive results. Here, we conducted a meta-analysis to summarize and clarify the association between TREM2 variants and AD, and examined the relationship between TREM2 genetic variant and the etiology of AD. Relevant case–control studies were retrieved and collected according to established inclusion criteria. Odds ratio (OR) and 95 % confidence interval (95 % CI) were used to estimate the associations between three TREM2 variants (rs75932628, rs104894002, and rs143332484) and AD. In overall meta-analysis, the summary ORs for rs75932628, rs104894002, and rs143332484 were 2.70 [95 % CI: 2.24, 3.24; P < 0.001], 7.21 (95 % CI: 1.28, 40.78; P = 0.025), and 1.65 (95 % CI: 1.24, 2.21; P = 0.001), respectively, indicating that the TREM2 rs75932628, rs104894002, and rs143332484 may contribute to AD risk. However, sensitivity analysis showed that the results of rs104894002 and rs143332484 should be interpreted with caution, and larger sample size, particularly in different ethnicities, are needed to validate the two variants. The current meta-analysis demonstrates that TREM2 is a candidate gene for AD susceptibility, and TREM2 variant rs75932628 may be a risk factor for AD.
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Metadata
Title
TREM2 variants and risk of Alzheimer’s disease: a meta-analysis
Authors
Yanjun Lu
Wei Liu
Xiong Wang
Publication date
01-10-2015
Publisher
Springer Milan
Published in
Neurological Sciences / Issue 10/2015
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-015-2274-2

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