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01-02-2015 | Original Article

Increased interictal serum levels of CXCL8/IL-8 and CCL3/MIP-1α in migraine

Authors: Halina Duarte, Antonio L. Teixeira, Natália P. Rocha, Renan B. Domingues

Published in: Neurological Sciences | Issue 2/2015

Abstract

Inflammatory mediators have been studied in migraine pathophysiology; however, their role is not yet well established. The aim of the present study was to investigate interictal chemokine levels and its association with clinical parameters and psychiatric comorbidities in migraine patients compared with controls. This was a cross-sectional study including age and gender matched migraine patients and controls. Beck Depression and Anxiety Inventories, Headache Impact Test, and Allodynia Symptom Checklist were recorded. Chemokines were measured by ELISA. Forty-nine migraine patients and forty-nine controls without headache were included. CXCL8/IL-8 and CCL3/MIP-1α levels were significantly higher among patients with migraine (P = 0.039 and 0.02, respectively) even after controlling for anxiety and depression scores. Chemokine levels were not correlated with migraine impact as well as allodynia scores. CXCL8/IL-8 and CCL3/MIP-1 α levels were raised in migraine, independently of psychiatric comorbidities, migraine impact, and allodynia.

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Title: Increased interictal serum levels of CXCL8/IL-8 and CCL3/MIP-1α in migraine
Authors: Halina Duarte
Antonio L. Teixeira
Natália P. Rocha
Renan B. Domingues
Publication date: 01-02-2015
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 2/2015
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-014-1931-1

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Increased interictal serum levels of CXCL8/IL-8 and CCL3/MIP-1α in migraine

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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