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01-01-2013 | Brief Communication

Predictive index for the onset of medication overuse headache in migraine patients

Authors: T. Onaya, M. Ishii, H. Katoh, S. Shimizu, H. Kasai, M. Kawamura, Y. Kiuchi

Published in: Neurological Sciences | Issue 1/2013

Abstract

Migraine patients are particularly prone to develop medication overuse headache (MOH). However, the risk factors for the transformation of migraine to MOH are still not clear. We investigated gene polymorphisms, personality traits, and characteristics of headache and lifestyle in 47 migraine patients (aged 36.4 ± 10.3) and 22 MOH patients (aged 39.6 ± 9.9) who progressed from migraine and made a scoring system for a predictive index (PI) of the onset of MOH in patients with migraine. By multivariate logistic stepwise regression analysis, type of migraine, regular and sufficient dietary intake, and methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133) and dopamine D2 receptor (DRD2) C939T (rs6275) polymorphisms were selected as significant factors that contribute independently to the development from migraine to MOH (P < 0.05). The regression coefficients (β) of these four selected factors were approximated and scored. The PI score in MOH patients (7.32 ± 1.60) was significantly higher than that in migraine patients (4.62 ± 1.83, P < 0.001). The proposed scoring system should in the future be the object of larger studies to confirm its validity.

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Title: Predictive index for the onset of medication overuse headache in migraine patients
Authors: T. Onaya
M. Ishii
H. Katoh
S. Shimizu
H. Kasai
M. Kawamura
Y. Kiuchi
Publication date: 01-01-2013
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 1/2013
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-012-0955-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Predictive index for the onset of medication overuse headache in migraine patients

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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