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01-12-2012 | Original Article

Targeting the brain: considerations in 332 consecutive patients treated by deep brain stimulation (DBS) for severe neurological diseases

Authors: Angelo Franzini, Roberto Cordella, Giuseppe Messina, Carlo Efisio Marras, Luigi Michele Romito, Alberto Albanese, Michele Rizzi, Nardo Nardocci, Giovanna Zorzi, Edvin Zekaj, Flavio Villani, Massimo Leone, Orsola Gambini, Giovanni Broggi

Published in: Neurological Sciences | Issue 6/2012

Abstract

Deep brain stimulation (DBS) extends the treatment of some severe neurological diseases beyond pharmacological and conservative therapy. Our experience extends the field of DBS beyond the treatment of Parkinson disease and dystonia, including several other diseases such as cluster headache and disruptive behavior. Since 1993, at the Istituto Nazionale Neurologico “Carlo Besta” in Milan, 580 deep brain electrodes were implanted in 332 patients. The DBS targets include Stn, GPi, Voa, Vop, Vim, CM–pf, pHyp, cZi, Nacc, IC, PPN, and Brodmann areas 24 and 25. Three hundred patients are still available for follow-up and therapeutic considerations. DBS gave a new therapeutic chance to these patients affected by severe neurological diseases and in some cases controlled life-threatening pathological conditions, which would otherwise result in the death of the patient such as in status dystonicus, status epilepticus and post-stroke hemiballismus. The balance of DBS in severe neurological disease is strongly positive even if further investigations and studies are needed to search for new applications and refine the selection criteria for the actual indications.

Bechtereva NP, Bondartchuk AN, Smirnov VM, Meliutcheva LA, Shandurina AN (1975) Method of electrostimulation of the deep brain structures in treatment of some chronic diseases. Confin Neurol 37:136–140PubMedCrossRef

Kringelbach ML, Jenkinson N, Owen SL, Aziz TZ (2007) Translational principles of deep brain stimulation. Nat Rev Neurosci 8:623–635PubMedCrossRef

Benabid AL, Pollak P, Louveau A, Henry S, de Rougemont J (1987) Combined (thalamotomy and stimulation) stereotactic surgery of the VIM thalamic nucleus for bilateral Parkinson disease. Appl Neurophysiol 50:344–346PubMed

Siegfried J, Lippitz B (1994) Bilateral chronic electrostimulation of ventroposterolateral pallidum: a new therapeutic approach for alleviating all parkinsonian symptoms. Neurosurgery 35:1126–1129 (discussion 1129–1130)PubMedCrossRef

Benabid AL, Pollak P, Gross C, Hoffmann D, Benazzouz A, Gao DM et al (1994) Acute and long-term effects of subthalamic nucleus stimulation in Parkinson’s disease. Stereotact Funct Neurosurg 62:76–84PubMedCrossRef

Benabid AL, Chabardes S, Mitrofanis J, Pollak P (2009) Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson’s disease. Lancet Neurol 8:67–81PubMedCrossRef

Limousin P (2008) Martinez-Torres, I. Deep brain stimulation for Parkinson’s disease. Neurotherapeutics 5:309–319PubMedCrossRef

Kleiner-Fisman G, Fisman DN, Sime E, Saint-Cyr JA, Lozano AM, Lang AE (2003) Long-term follow up of bilateral deep brain stimulation of the subthalamic nucleus in patients with advanced Parkinson disease. J Neurosurg 99:489–495PubMedCrossRef

Pahwa R, Wilkinson SB, Overman J, Lyons KE (2005) Preoperative clinical predictors of response to bilateral subthalamic stimulation in patients with Parkinson’s disease. Stereotact Funct Neurosurg 83:80–83PubMedCrossRef

10.

Rodriguez-Oroz MC, Obeso JA, Lang AE, Houeto JL, Pollak P, Rehncrona S et al (2005) Bilateral deep brain stimulation in Parkinson’s disease: a multicentre study with 4 years follow-up. Brain 128:2240–2249PubMedCrossRef

11.

Romito LM, Scerrati M, Contarino MF, Bentivoglio AR, Tonali P, Albanese A (2002) Long-term follow up of subthalamic nucleus stimulation in Parkinson’s disease. Neurology 58:1546–1550PubMedCrossRef

12.

Visser-Vandewalle V, van der Linden C, Temel Y, Celik H, Ackermans L, Spincemaille G, Caemaert J (2005) Long-term effects of bilateral subthalamic nucleus stimulation in advanced Parkinson disease: a four year follow-up study. Parkinsonism Relat Disord 11:157–165

13.

Zibetti M, Pesare M, Cinquepalmi A, Rosso M, Bergamasco B, Ducati A, Lanotte M, Lopiano L (2008) Antiparkinsonian therapy modifications in PD patients after STN DBS: a retrospective observational analysis. Parkinsonism Relat Disord 14:608–612PubMedCrossRef

14.

Krack P, Batir A, Van Blercom N, Chabardes S, Fraix V, Ardouin C, Koudsie A, Limousin PD, Benazzouz A, LeBas JF, Benabid AL, Pollak P (2003) Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson’s disease. N Engl J Med 349:1925–1934PubMedCrossRef

15.

Romito LM, Contarino MF, Vanacore N, Bentivoglio AR, Scerrati M, Albanese A (2009) Replacement of dopaminergic medication with subthalamic nucleus stimulation in Parkinson’s disease: long-term observation. Mov Disord 24:557–563PubMedCrossRef

16.

Schupbach WM, Chastan N, Welter ML, Houeto JL, Mesnage V, Bonnet AM et al (2005) Stimulation of the subthalamic nucleus in Parkinson’s disease: a 5 year follow up. J Neurol Neurosurg Psychiatry 76:1640–1644PubMedCrossRef

17.

Simonin C, Tir M, Devos D, Kreisler A, Dujardin K, Salleron J et al (2009) Reduced levodopa-induced complications after 5 years of subthalamic stimulation in Parkinson’s disease: a second honeymoon. J Neurol 256:1736–1741PubMedCrossRef

18.

Wider C, Pollo C, Bloch J, Burkhard PR, Vingerhoets FJ (2008) Long-term outcome of 50 consecutive Parkinson’s disease patients treated with subthalamic deep brain stimulation. Parkinsonism Relat Disord 14:114–119 (Epub 2007 Sep 5)

19.

Fasano A, Romito LM, Daniele A, Piano C, Zinno M, Bentivoglio AR, Albanese A (2010) Motor and cognitive outcome in patients with Parkinson’s disease 8 years after subthalamic implants. Brain 133:2664–2676PubMedCrossRef

20.

Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55:181–184PubMedCrossRef

21.

Defer GL, Widner H, Marie RM, Remy P, Levivier M (1999) Core assessment program for surgical interventional therapies in Parkinson’s disease (CAPSIT-PD). Mov Disord 14:572–584PubMedCrossRef

22.

Bakay R (2008) Movement disorder surgery: the essentials. Thieme, New York

23.

Wycis HT, Spiegel EA (1950) The effect of thalamotomy and pallidotomy upon involuntary movements in chorea and athetosis. Surg Forum, pp 329–332

24.

Svennilson E, Torvik A, Lowe R, Leksell L (1960) Treatment of Parkinsonism by stereotactic thermolesions in the pallidal region. A clinical evaluation of 81 cases. Acta Psychiatr Scand 35:358–377PubMedCrossRef

25.

Laitinen LV, Bergenheim AT, Hariz MI (1992) Leksell’s posteroventral pallidotomy in the treatment of Parkinson’s disease. J Neurosurg 76:53–61PubMedCrossRef

26.

Pollak P, Benabid AL, Gross C, Gao DM, Laurent A, Benazzouz A et al (1993) Effects of the stimulation of the subthalamic nucleus in Parkinson disease. Rev Neurol (Paris) 149:175–176

27.

Siegfried J, Wellis G (1997) Chronic electrostimulation of ventroposterolateral pallidum: follow-up. Acta Neurochir Suppl 68:11–13PubMed

28.

Coubes P, Echenne B, Roubertie A, Vayssière N, Tuffery S, Humbertclaude V, Cambonie G, Claustres M, Frerebeau P (1999) Treatment of early-onset generalized dystonia by chronic bilateral stimulation of the internal globus pallidus. Apropos of a case. Neurochirurgie 45:139–144PubMed

29.

Krauss JK, Pohle T, Weber S, Ozdoba C, Burgunder JM (1999) Bilateral stimulation of globus pallidus internus for treatment of cervical dystonia. Lancet 354:837–838PubMed

30.

Coubes P, Roubertie A, Vayssiere N et al (2000) Treatment of DYT1-generalised dystonia by stimulation of the internal globus pallidus. Lancet 355:2220e1CrossRef

31.

Angelini L, Nardocci N, Estienne M, Conti C, Dones I (2000) Broggi G Life-threatening dystonia-dyskinesias in a child: successful treatment with bilateral pallidal stimulation. Mov Disord 15:1010–1012PubMedCrossRef

32.

Mueller J et al (2008) Deep-brain stimulation for Dystonia Study Group Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: results from a prospective, randomized sham-controlled trial. Mov Disord 23:131–134PubMedCrossRef

33.

Zorzi G, Marras C, Nardocci N, Franzini A, Chiapparini L, Maccagnano E et al (2005) Stimulation of the globus pallidus internus for childhood-onset dystonia. Mov Disord 20:1194–1200PubMedCrossRef

34.

Fahn S, Bressman SB, Marsden CD (1998) Classification of dystonia. Adv Neurol 78:1–9PubMed

35.

Franzini A, Marras C, Ferroli P, Zorzi G, Bugiani O, Romito L, Broggi G (2005) Long-term high-frequency bilateral pallidal stimulation for neuroleptic-induced tardive dystonia. Report of two cases. J Neurosurg 102:721–725PubMedCrossRef

36.

Marras C, Zorzi G, Lenardi C, Rizzi M, Messina G, Alimehmeti R et al (2009) A Deep brain stimulation electrode used for radiofrequency lesion of the globus pallidus internus in dystonia. Stereotact Funct Neurosurg 87:348–352 (Epub 2009 Sep 10)

37.

Piacentini S, Romito L, Franzini A, Granato A, Broggi G, Albanese A (2008) Mood disorder following DBS of the left amygdaloid region in a dystonia patient with a dislodged electrode. Mov Disord 23:147–150PubMedCrossRef

38.

Parrent AG (1998) Overview of the surgical treatment of movement disorders. In: Tasker RR, Gildenberg PL (eds) Textbook of Stereotactic and Functional Neurosurgery. McGraw-Hill, New York, pp 995–1003

39.

Hassler R, Riechart T, Munginer F, Umbach W, Ganglberger JA (1960) Physiological observations in stereotaxic operations in extrapyramidal motor disturbances. Brain 83:337–350PubMedCrossRef

40.

Benabid AL, Pollak P, Hommel M, Gaio JM, de Rougemont J, Perret J (1989) Treatment of Parkinson tremor by chronic stimulation of the ventral intermediate nucleus of the thalamus. Rev. Neurol. (Paris) 145:320–323

41.

Broggi G, Brock S, Franzini A, Geminiani G (1993) A case of posttraumatic tremor treated by chronic stimulation of the thalamus. Mov Disord 8:206–208PubMedCrossRef

42.

Koller W, Pahwa R, Busenbark K, Hubble J, Wilkinson S, Lang A et al (1997) High-frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor. Ann Neurol 42:292–299PubMedCrossRef

43.

Koller WC, Lyons KE, Wilkinson SB, Troster AI, Pahwa R (2001) Long-term safety and efficacy of unilateral deep brain stimulation of the thalamus in essential tremor. Mov Disord 16:464–468PubMedCrossRef

44.

Limousin P, Speelman JD, Gielen F, Janssens M (1999) Multicentre European study of thalamic stimulation in parkinsonian and essential tremor. J Neurol Neurosurg Psychiatry 66:289–296PubMedCrossRef

45.

Geny C, Nguyen JP, Pollin B, Feve A, Ricolfi F, Cesaro P et al (1996) Improvement of severe postural cerebellar tremor in multiple sclerosis by chronic thalamic stimulation. Mov Disord 11:489–494PubMedCrossRef

46.

Kudo M, Goto S, Nishikawa S, Hamasaki T, Soyama N, Ushio Y et al (2001) Bilateral thalamic stimulation for Holmes’ tremor caused by unilateral brainstem lesion. Mov Disord 16:170–174PubMedCrossRef

47.

Nikkhah G, Prokop T, Hellwig B, Lucking CH, Ostertag CB (2004) Deep brain stimulation of the nucleus ventralis intermedius for Holmes (rubral) tremor and associated dystonia caused by upper brainstem lesions. Report of two cases. J Neurosurg 100:1079–1083PubMedCrossRef

48.

Payne MS, Brown BL, Rao J, Payne BR (2005) Treatment of phenylketonuria-associated tremor with deep brain stimulation: case report. Neurosurgery 56:E868PubMedCrossRef

49.

Schramm P, Scheihing M, Rasche D, Tronnier VM (2005) Behr syndrome variant with tremor treated by VIM stimulation. Acta Neurochir (Wien) 147:679–683 (discussion 83)

50.

Benabid AL, Pollak P, Gervason C, Hoffmann D, Gao DM, Hommel M et al (1991) Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus. Lancet 337:403–406PubMedCrossRef

51.

Taha JM, Janszen MA, Favre J (1999) Thalamic deep brain stimulation for the treatment of head, voice, and bilateral limb tremor. J Neurosurg 91:68–72PubMedCrossRef

52.

Pahwa R, Lyons KE, Wilkinson SB, Simpson RK Jr, Ondo WG, Tarsy D et al (2006) Long-term evaluation of deep brain stimulation of the thalamus. J Neurosurg 104:506–512PubMedCrossRef

53.

Critchley GR, Richardson PL (1998) Vim thalamotomy for the relief of the intention tremor of multiple sclerosis. Br J Neurosurg 12:559–562PubMedCrossRef

54.

Bittar RG, Hyam J, Nandi D, Wang S, Liu X, Joint C et al (2005) Thalamotomy versus thalamic stimulation for multiple sclerosis tremor. J Clin Neurosci 12:638–642PubMedCrossRef

55.

Deuschl G, Raethjen J, Lindemann M, Krack P (2001) The pathophysiology of tremor. Muscle Nerve 24:716–735PubMedCrossRef

56.

Foote KD, Okun MS (2005) Ventralis intermedius plus ventralis oralis anterior and posterior deep brain stimulation for posttraumatic Holmes tremor: two leads may be better than one: technical note. Neurosurgery 56:E445PubMedCrossRef

57.

Broggi G, Franzini A, Tringali G, Ferrali P, Marras C, Romito L et al (2006) Deep brain stimulation as a functional scalpel. Acta Neurochir Suppl 99:13–19PubMedCrossRef

58.

Ondo W, Jankovic J, Schwartz K, Almaguer M, Simpson RK (1998) Unilateral thalamic deep brain stimulation for refractory essential tremor and Parkinson’s disease tremor. Neurology 51:1063–1069PubMedCrossRef

59.

Lyons KE, Pahwa R, Comella CL, Eisa MS, Elble RJ, Fahn S et al (2003) Benefits and risks of pharmacological treatments for essential tremor. Drug Saf 26:461–481PubMedCrossRef

60.

Forel A (1877) Untersuchungen über die Haubenregion und ihre oberen Verknüpfungen im Gehirne des Menschen und einiger Säugethiere, mit Beiträgen zu den Methoden der Gehirnuntersuchung. Archiv für Psychiatrie und Nervenkrankheiten 7:393–495CrossRef

61.

Jones EG (1985) The thalamus. Plenum Press, New York

62.

Mitrofanis J (2005) Some certainty for the “zone of uncertainty”? Exploring the function of the zona incerta. Neuroscience 130:1–15PubMedCrossRef

63.

Nicolelis MA, Chapin JK, Lin RC (1995) Development of direct GABAergic projections from the zona incerta to the somatosensory cortex of the rat. Neuroscience 65:609–631PubMedCrossRef

64.

Roger M, Cadusseau J (1985) Afferents to the zona incerta in the rat: a combined retrograde and anterograde study. J Comp Neurol 241:480–492PubMedCrossRef

65.

Romanowski CA, Mitchell IJ, Crossman AR (1985) The organisation of the efferent projections of the zona incerta. J Anat 143:75–95PubMed

66.

Mok D, Mogenson G (1986) Contribution of zona incerta to osmotically induced drinking in rats. J Am J Physiol 251:R823–R832

67.

Shammah-Lagnado SJ, Negrão N, Ricardo JA (1985) Afferent connections of the zona incerta: a horseradish peroxidase study in the rat. Neuroscience 15:109–134PubMedCrossRef

68.

Ficalora AS, Mize RR (1989) The neurons of the substantia nigra and zona incerta which project to the cat superior colliculus are GABA immunoreactive: a double-label study using GABA immunocytochemistry and lectin retrograde transport. Neuroscience 29:567–581PubMedCrossRef

69.

Vives F, Mogenson GJ (1985) Electrophysiological evidence that the mediodorsal nucleus of the thalamus is a relay between the ventral pallidum and the medial prefrontal cortex in the rat. Brain Res 344:329–337PubMedCrossRef

70.

Houdart R, Mamo H, Dondey M, Cophignon J (1965) Results of subthalamic coagulations in Parkinson’s disease (apropos of 50 cases). Rev Neurol (Paris) 112:521–529

71.

Mundinger F (1965) Stereotaxic interventions on the zona incerta area for treatment of extrapyramidal motor disturbances and their results. Confin Neurol 26:222–230PubMed

72.

Patel NK, Heywood P, O’Sullivan K, McCarter R, Love S, Gill SS (2003) Unilateral subthalamotomy in the treatment of Parkinson’s disease. Brain 126:1136–1145PubMedCrossRef

73.

Kitagawa M, Murata J, Uesugi H, Kikuchi S, Saito H, Tashiro K, Sawamura Y (2005) Two-year follow-up of chronic stimulation of the posterior subthalamic white matter for tremor-dominant Parkinson’s disease. Neurosurgery 56:281–289PubMedCrossRef

74.

Plaha P, Ben-Shlomo Y, Patel NK, Gill SS (2006) Stimulation of the caudal zona incerta is superior to stimulation of the subthalamic nucleus in improving contralateral parkinsonism. Brain 129:1732–1747 (epub 2006 May 23)

75.

Plaha P, Khan S, Gill SS (2008) Bilateral stimulation of the caudal zona incerta nucleus for tremor control. J Neurol Neurosurg Psychiatry 79:504–513 (epub 2007 Nov 23)

76.

Velasco F, Jiménez F, Pérez ML, Carrillo-Ruiz JD, Velasco AL, Ceballos J et al (2001) Electrical stimulation of the prelemniscal radiation in the treatment of Parkinson’s disease: an old target revised with new techniques. Neurosurgery 49:293–306 (discussion 306–308)

77.

Piasecki SD, Jefferson JW (2004) Psychiatric complications of deep brain stimulation for Parkinson’s disease. J Clin Psychiatry 65:845–849PubMedCrossRef

78.

Saint-Cyr JA, Trépanier LL, Kumar R, Lozano AM, Lang AE (2000) Neuropsychological consequences of chronic bilateral stimulation of the subthalamic nucleus in Parkinson’s disease. Brain 123:2091–2108PubMedCrossRef

79.

Franzini A, Messina G, Marras G, Villani F, Cordella R, Broggi G (2008) Deep Brain Stimulation of two unconventional targets in refractory non-resectable epilepsy. Stereotact Funct Neurosurg 86:373–381PubMedCrossRef

80.

Adams JE, Hosobuchi Y, Fields HL (1974) Stimulation of internal capsule for relief of chronic pain. J Neurosurg 41:740–744PubMedCrossRef

81.

Fields HL, Adams JE (1974) Pain after cortical injury relieved by electrical stimulation of the internal capsule. Brain 97:169–178PubMedCrossRef

82.

Hosobuchi Y, Adams JE, Rutkin B (1975) Chronic thalamic and internal capsule stimulation for the control of central pain. Surg Neurol 4:91–92PubMed

83.

Kumar K, Toth C, Nath RK (1997) Deep brain stimulation for intractable pain. A 15-years experience. Neurosurgery 40:736–747PubMedCrossRef

84.

Levy RM, Lamb S, Adams JE (1987) Treatment of chronic pain by deep brain stimulation: long term follow-up and review of the literature. Neurosurgery 21:885–893PubMedCrossRef

85.

Namba S, Nakao Y, Matsumoto Y, Ohmoto T, Nishimoto A (1984) Electrical stimulation of the posterior limb of the internal capsule for treatment of thalamic pain. Appl Neurophysiol 47:137–148PubMed

86.

Namba S, Wani T, Shimizu Y, Fujiwara N, Namba Y, Nakamua S, Nishimoto A (1985) Sensory and motor responses to beep brain stimulation. Correlation with anatomical structures. J Neurosurg 63:224–234PubMedCrossRef

87.

Turnbull IM, Shulman R, Woodhurst WB (1980) Thalamic stimulation for neuropathic pain. J Neurosurg 52:486–493PubMedCrossRef

88.

Young RF, Kroening R, Fulton W, Feldman RA, Chambi I (1985) Electrical stimulation of the brain in the treatment of chronic pain. Experience over 5 years. J Neurosurg 62:389–396PubMedCrossRef

89.

Cooper IS, Upton AR, Amin I (1980) Reversibility of chronic neurological deficits. Some effects of electrical stimulation of the thalamus and internal capsule in man. Appl Neurophysiol 43:244–258PubMed

90.

Cooper IS, Upton AR, Amin I (1982) Reversibility of chronic cerebral stimulation (CCS) and deep brain stimulation (DBS) in involuntary movement disorders. Appl Neurophysiol 45:209–217PubMed

91.

Akil H, Richardson DE, Hughes J, Barchas JD (1978) Enkephalin-like material elevated in ventricular cerebrospinal fluid of pain patients after analgesic focal stimulation. Science 201:463–465PubMedCrossRef

92.

Nishimoto A, Namba S, Nakao Y, Matsumoto Y, Ohmoto T (1984) Inhibition of nociceptive neurons by internal capsule stimulation. Appl Neurophysiol 47:117–127PubMed

93.

Franzini A, Ferroli P, Servello D, Broggi G (2000) Reversal of thalamic hand syndrome by long-term motor cortex stimulation. J Neurosurg 93:873–875PubMedCrossRef

94.

Franzini A, Ferroli P, Dones I, Marras C, Broggi G (2003) Chronic motor cortex stimulation for movement disorders: a promising perspective. Neurol Res 25:123–126PubMedCrossRef

95.

Franzini A, Cordella R, Nazzi V, Broggi G (2008) Long Term Chronic Stimulation of Internal Capsule in Post-Stroke Pain and Spasticity—Case Report of Long Term Results and Review of the Literature. Stereotact Funct Neurosurg 86:179–183PubMedCrossRef

96.

Franzini A, Messina G, Marras C, Molteni F, Cordella R, Soliveri P, Broggi G (2009) Poststroke fixed dystonia of the foot relieved by chronic stimulation of the internal capsule’s posterior limb. J Neurosurg 111:1216–1219PubMedCrossRef

97.

Hécaen H, Talairach J, David M, Dell MB (1949) Coagulations limitées du thalamus dans les algies du syndrome thalamique. Rev Neurol 81:917–931

98.

Leksell L, Meyerson BA, Forster DM (1972) Radiosurgical thalamotomy for intractable pain. Confin Neurol 34:264CrossRef

99.

Weigel R, Krauss JK (2004) Center median–parafascicular complex and pain control. Review from a neurosurgical perspective. Stereotact Funct Neurosurg 82:115–126PubMedCrossRef

100.

Velasco F, Velasco M, Velasco AL, Jiménez F, Marquez I, Rise M (1995) Electrical stimulation of centromedian thalamic nucleus in control of seizures: long term studies. Epilepsia 36:63–71PubMedCrossRef

101.

Velasco AL, Velasco F, Velasco M, Jiménez F, Carrillo-Ruiz JD, Castro G (2007) The role of neuromodulation of the hippocampus in the treatment of intractable complex partial seizures of the temporal lobe. Acta Neurochir (Suppl) 97:329–332CrossRef

102.

Velasco F, Velasco AL, Velasco M, Jiménez F, Carrillo-Ruiz JD, Castro G (2007) Deep brain stimulation for treatment of the epilepsies: the centromedian thalamic target. Acta Neurochir (Suppl) 97:337–342CrossRef

103.

Velasco AL, Velasco F, Velasco M, Trejo D, Castro G, Carrillo-Ruiz JD (2007) Electrical stimulation of the hippocampal epileptic foci for seizure control: a double-blind, long-term follow-up study. Epilepsia 48:1895–1903PubMedCrossRef

104.

Albe-Fessard D, Besson JM (1973) Convergent thalamic and cortical projection—the non-specific system. In: Iggo A (ed) Handbook of Sensory Physiology. Somatosensory System, vol 2. Springer, Berlin, pp 490–560

105.

Caparros-Lefebvre D, Blond S, Feltin MP, Pollak P, Benabid AL (1999) Improvement of levodopa induced dyskinesias by thalamic deep brain stimulation is related to slight variation in electrode placement: possible involvement of the centre median and parafascicularis complex. J Neurol Neurosurg Psychiatry 67:308–314PubMedCrossRef

106.

Mazzone P, Stocchi F, Galati S, Insola A, Altibrandi MG, Modugno N et al (2006) Bilateral implantation of centromedian–parafascicularis complex and GPi: A new combination of unconventional targets for deep brain stimulation in severe Parkinson disease. Neuromodulation 9:221–228PubMedCrossRef

107.

Visser-Vandewalle V, Temel Y, Boon P, Vreeling F, Colle H, Hoogland G et al (2003) Chronic bilateral thalamic stimulation: a new therapeutic approach in intractable Tourette syndrome. Report of three cases. J Neurosurg 99:1094–1100PubMedCrossRef

108.

Servello D, Porta M, Sassi M, Brambilla A, Robertson MM (2008) Deep brain stimulation in 18 patients with severe Gilles de la Tourette syndrome refractory to treatment: the surgery and stimulation. J Neurol Neurosurg Psychiatry 79:136–142PubMedCrossRef

109.

Cukiert A, Burattini JA, Cukiert CM, Argentoni-Baldochi M, Baise-Zung C, Forster CR et al (2009) Centro-median stimulation yields additional seizure frequency and attention improvement in patients previously submitted to callosotomy. Seizure 18:588–592PubMedCrossRef

110.

Lin JS, Sakay K, Vanni-Mercier G, Jouvet M (1989) A critical role of the posterior hypothalamus in the mechanisms of wakefulness determined by microinjection of muscimol in freely moving cats. Brain Res 479:225–240PubMedCrossRef

111.

Sallanon M, Denoyer M, Kitahama K, Aubert C, Gay N, Jouvet M (1989) Longlasting insomnia induced by preoptic neuron lesions and its transient reversal by muscimol injection into the posterior hypothalamus in the cat. Neuroscience 32:669–683PubMedCrossRef

112.

Sano K (1962) Sedative neurosurgery with special reference to posteromedial hypothalamotomy. Neurol Med Chir (Tokyo) 4:112–142CrossRef

113.

Sano K, Yoshioka M, Ogashiwa M, Ishijima B, Ohye C (1966) Postero-medial hypothalamotomy in the treatment of aggressive behaviours. Confinia neurol 27:164–167CrossRef

114.

Sano K, Mayanagi Y, Sekino H, Ogashiwa M, Ishijima B (1970) Results of stimulation and destruction of the posterior hypothalamus in man. J Neurosurg 33:689–707PubMedCrossRef

115.

Abrahamson EE, Moore RY (2001) The posterior hypothalmic area: chemoarchitecture and afferent connections. Brain Res 889:1–22PubMedCrossRef

116.

Cavdar S, Onat F, Aker R, Sehirli U, San T, Yananli HR (2001) The afferent connections of the posterior hypothalamic nucleus in the rat using horseradish peroxidase. J Anat 198:463–472PubMedCrossRef

117.

Franzini A, Ferroli P, Leone M, Broggi G (2003) Stimulation of the posterior hypothalamus for treatment of chronic intractable cluster headaches: first reported series. Neurosurgery 52:1095–1101PubMedCrossRef

118.

Leone M, Franzini A (2001) Bussone G: Stereotactic stimulation of posterior hypothalamic gray matter in a patient with intractable cluster headache. N Engl J Med 345:1428–1429PubMedCrossRef

119.

Schoenen J, Di Clemente L, Vandenheede M, Fumal A, De Pasqua V, Mouchamps M et al (2005) Hypothalamic stimulation in chronic cluster headache: a pilot study of efficacy and mode of action. Brain 128:940–947PubMedCrossRef

120.

May A, Bahra A, Buchel C, Frackowiak KJ, Goadsby P (1998) Hypothalamic activation in cluster headache attacks. Lancet 352:275–278PubMedCrossRef

121.

Sprenger T, Boecker H, Toelle TR, Bussone G, May A, Leone M (2004) Specific hypothalamic activation during a spontaneous cluster headache attack. Neurology 3:516–517CrossRef

122.

Franzini A, Messina G, Cordella R, Marras C, Broggi G (2010) DBS of the posteromedial hypothalamus: indications, long-term results and neurophysiological considerations. Neurosurg Focus 29:E13PubMedCrossRef

123.

Cordella R, Franzini A, La Mantia L, Marras C, Erbetta A, Broggi G (2009) Hypothalamic stimulation for trigeminal neuralgia in multiple sclerosis patients: efficacy on the paroxysmal ophthalmic pain. Mult Scler 15:1322–1328PubMedCrossRef

124.

Franzini A, Leone M, Messina G, Cordella R, Marras C, Bussone G et al (2008) Neuromodulation in treatment of refractory headaches. Neurol Sci 29(Suppl 1):S65–S68PubMedCrossRef

125.

Franzini A, Marras C, Ferroli P, Bugiani O, Broggi G (2005) Stimulation of the posterior hypothalamus for medically intractable impulsive and violent behavior. Stereotact Funct Neurosurg 83:63–66PubMedCrossRef

126.

Franzini A, Broggi G (2009) Treatment of aggressive behaviour. In: Lozano AM, Gildenberg P, Tasker R (eds) Textbook of Stereotactic and Functional Neurosurgery, 2nd edn, vol 2. Springer Verlag, Berlin, pp 2971–2977

127.

Heath RG (1963) Electrical self-stimulation of the brain in man. Am J Psychiatry 120:571–577PubMed

128.

Laitinen LV (1979) Emotional responses to subcortical electrical stimulation in psychiatric patients. Clin Neurol Neurosurg 81:148–157PubMedCrossRef

129.

Hariz MI, Blomstedt P, Zrinzo L (2010) Deep brain stimulation between 1947 and 1987: the untold story. Neurosurg Focus 29:E1PubMedCrossRef

130.

Guridi J, Manrique M (2009) History of stereotactic surgery in Spain. In: Lozano AM, Gildenberg PL, Tasker RR (eds) Textbook of stereotactic and functional neurosurgery. Springer-Verlag, Berlin, pp 179–191CrossRef

131.

Nuttin B, Cosyns P, Demeulemeester H, Gybels J, Meyerson B (1999) Electrical stimulation in anterior limbs of internal capsules in patients with obsessive–compulsive disorder. Lancet 354:1526PubMedCrossRef

132.

Sturm V, Lenartz D, Koulousakis A, Treuer H, Herholz K, Klein JC, Klosterkötter J (2003) The nucleus accumbens: a target for deep brain stimulation in obsessive–compulsive- and anxiety-disorders. J Chem Neuroanat 26:293–299PubMedCrossRef

133.

Alheid GF, Beltramino CA, De Olmos JS, Forbes MS, Swanson DJ, Heimer L (1998) The neuronal organization of the supracapsular part of the stria terminalis in the rat: the dorsal component of the extended amygdala. Neuroscience 84:967–996PubMedCrossRef

134.

de Olmos JS, Heimer L (1999) The concepts of the ventral striatopallidal system and extended amygdala. Ann N Y Acad Sci 877:1–32PubMedCrossRef

135.

Grace AA (1993) Cortical regulation of subcortical dopamine systems and its possible relevance to schizophrenia. J Neural Transm Gen Sect 91:111–134PubMedCrossRef

136.

Mulder AB, Hodenpijl MG, Lopes da Silva FH (1998) Electrophysiology of the hippocampal and amygdaloid projections to the nucleus accumbens of the rat: convergence, segregation, and interaction of inputs. J Neurosci 18:5095–5102PubMed

137.

Rosenkranz JA, Grace AA (1999) Modulation of basolateral amygdala neuronal firing and afferent drive by dopamine receptor activation in vivo. J Neurosci 19:11027–11039PubMed

138.

Huff W, Lenartz D, Schormann M, Lee SH, Kuhn J, Koulousakis A et al (2010) Unilateral deep brain stimulation of the nucleus accumbens in patients with treatment-resistant obsessive–compulsive disorder: Outcomes after one year. Clin Neurol Neurosurg 112:137–143 (epub 2009 Dec 16)

139.

Mian MK, Campos M, Sheth SA, Eskandar EN (2010) Deep brain stimulation for obsessive–compulsive disorder: past, present, and future. Neurosurg Focus 29:E10PubMedCrossRef

140.

Franzini A, Messina G, Gambini O, Muffatti R, Scarone S, Cordella R, Broggi G (2010) Deep-brain stimulation of the nucleus accumbens in obsessive compulsive disorder: clinical, surgical and electrophysiological considerations in two consecutive patients. Neurol Sci 31:353–359 (epub 2010 Feb 3)

141.

Drevets WC (2000) Neuroimaging studies of mood disorders. Biol Psychiatry 48:813–829PubMedCrossRef

142.

Mayberg HS, Liotti M, Brannan SK, McGinnis S, Mahurin RK, Jerabek PA et al (1999) Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. Am J Psychiatry 156:675–682PubMed

143.

Seminowicz DA, Mayberg HS, McIntosh AR, Goldapple K, Kennedy S, Segal Z, Rafi-Tari S (2004) Limbic-frontal circuitry in major depression: a path modelling metanalysis. Neuroimage 22:409–418PubMedCrossRef

144.

Dougherty DD, Weiss AP, Cosgrove GR, Alpert NM, Cassem EH, Nierenberg AA et al (2003) Cerebral metabolic correlates as potential predictors of response to anterior cingulotomy for treatment of major depression. J Neurosurg 99:1010–1017PubMedCrossRef

145.

Mayberg HS, Brannan SK, Tekell JL, Silva JA, Mahurin RK, McGinnis S, Jerabek PA (2000) Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response. Biol Psychiatry 48:830–843PubMedCrossRef

146.

Mottaghy FM, Keller CE, Gangitano M, Ly J, Thall M, Parker JA, Pascual-Leone A (2002) Correlation of cerebral blood flow and treatment effects of repetitive transcranial magnetic stimulation in depressed patients. Psychiatry Res 115:1–14PubMedCrossRef

147.

Mayberg HS, Lozano AM, Voon V, McNeely HE, Seminowicz D, Hamani C et al (2005) Deep brain stimulation for treatment-resistant depression. Neuron 45:651–660PubMedCrossRef

148.

Pillay PK, Hassenbusch SJ (1992) Bilateral MRI-guided stereotactic cingulotomy for intractable pain. Stereotact Funct Neurosurg 59:33–38PubMedCrossRef

149.

Spooner J, Yu H, Kao C, Sillay K, Konrad P (2007) Neuromodulation of the cingulum for neuropathic pain after spinal cord injury. Case report. J Neurosurg 107:169–172PubMedCrossRef

150.

Hutchison WD, Davis KD, Lozano AM, Tasker RR, Dostrovsky JO (1999) Pain-related neurons in the human cingulate cortex. Nat Neurosci 2:403–405PubMedCrossRef

151.

Aziz TZ, Davies L, Stein J, France S (1998) The role of descending basal ganglia connections to the brain stem in parkinsonian akinesia. Br J Neurosurg 12:245–249PubMedCrossRef

152.

Mazzone P, Lozano A, Stanzione P, Galati S, Scarnati E, Peppe A, Stefani A (2005) Implantation of human pedunculopontine nucleus: a safe and clinically relevant target in Parkinson’s disease. Neuroreport 16:1877–1881PubMedCrossRef

153.

Plaha P, Gill SS (2005) Bilateral deep brain stimulation of the pedunculopontine nucleus for Parkinson’s disease. Neuroreport 16:1883–1887PubMedCrossRef

154.

Ferraye MU, Debû B, Fraix V, Goetz L, Ardouin C, Yelnik J et al (2010) Effects of pedunculopontine nucleus area stimulation on gait disorders in Parkinson’s disease. Brain 133:205–214PubMedCrossRef

155.

Peppe A, Pierantozzi M, Chiavalon C, Marchetti F, Caltagirone C, Musicco M, Stanzione P, Stefani A (2010) Deep brain stimulation of the pedunculopontine tegmentum and subthalamic nucleus: effects on gait in Parkinson’s disease. Gait Posture 32(4):512–518

156.

Moro E, Hamani C, Poon YY, Al-Khairallah T, Dostrovsky JO, Hutchison WD, Lozano AM (2010) Unilateral pedunculopontine stimulation improves falls in Parkinson’s disease. Brain 133:215–224PubMedCrossRef

157.

Stefani A, Lozano AM, Peppe A, Stanzione P, Galati S, Tropepi D, Pierantozzi M, Brusa L, Scarnati E, Mazzone P (2007) Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson’s disease. Brain 130:1596–1607PubMedCrossRef

158.

Zrinzo L, Zrinzo LV, Tisch S, Limousin PD, Yousry TA, Afshar F, Hariz MI (2008) Stereotactic localization of the human pedunculopontine nucleus: atlas-based coordinates and validation of a magnetic resonance imaging protocol for direct localization. Brain 131:1588–1598 (epub 2008 May 8)

Title: Targeting the brain: considerations in 332 consecutive patients treated by deep brain stimulation (DBS) for severe neurological diseases
Authors: Angelo Franzini
Roberto Cordella
Giuseppe Messina
Carlo Efisio Marras
Luigi Michele Romito
Alberto Albanese
Michele Rizzi
Nardo Nardocci
Giovanna Zorzi
Edvin Zekaj
Flavio Villani
Massimo Leone
Orsola Gambini
Giovanni Broggi
Publication date: 01-12-2012
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 6/2012
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-012-0937-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Targeting the brain: considerations in 332 consecutive patients treated by deep brain stimulation (DBS) for severe neurological diseases

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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