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01-06-2010 | Original Article

Migraine and cerebral infarction in young people

Authors: Massimo Camerlingo, A. Romorini, C. Ferrante, L. Valente, L. Moschini

Published in: Neurological Sciences | Issue 3/2010

Abstract

The objective of this study is to investigate relationship between migraine and cerebral infarction in young people. Patients aging 16–44 years, referred for stroke and age- and gender-matched controls were investigated for migraine following the International Headache Society criteria. Included people were 314 strokes and 314 controls. Each group consisted of 150 men and 164 women. Of the 105 persons with migraine (16.7%), 57 had migraine with aura (9.1%). In women, migraine with aura was related to stroke [35 women among strokes (21.3%) vs. 9 among controls (5.5%), P < 0.0001], whereas migraine without aura was not. After multivariate analysis, migraine with aura remained independently associated with stroke together with hypertension, and the estro-progestinic utilization. In men, migraine was not associated with stroke. In conclusion, migraine with aura appears to be associated with ischemic stroke in young women, independently from other common risk factors.

Henrich JB, Horwitz RI (1989) A controlled study of ischemic stroke risk in migraine patients. J Clin Epidemiol 49:773–780CrossRef

Tzourio C, Iglesias S, Hubert JB, Visy JM, Alperovich A, Tehindrazanarivelo A, Biousse V, Woimant F, Bousser MG (1993) Migraine and risk of ischaemic stroke: a case-control study. BMJ 307:289–292CrossRefPubMed

Lidegaard O (1995) Oral contraceptives, pregnancy, and the risk of cerebral thromboembolism: the influence of diabetes, hypertension, migraine, and previous thrombotic disease. Br J Obstet Gynaecol 102:153–159PubMed

Buring J, Herbert P, Romero J, Kittross A, Cook N, Manson J, Peto R, Hennekens C (1995) Migraine and subsequent risk of stroke in the Physicians’ health study. Arch Neurol 52:129–134PubMed

Carolei A, Marini C, DeMatteis G (1996) and the Italian National Research Council Study Group on Stroke in the Young. Lancet 347:1503–1506PubMed

Haapaniemi H, Hillbom M, Juvela S (1997) Lifestyle-associated risk factors for acute brain infarction among persons of working age. Stroke 28:3–26

Merikangas KR, Fenton BT, Cheng SH, Stolar MJ, Risch N (1997) Association between migraine and stroke in a large-scale epidemiological study on the United States. Arch Neurol 54:362–368PubMed

Chang CL, Donaghy M, Boulter N (1999) Migraine and stroke in young women: case-control study. BMJ 318:13–18PubMed

Jousilathi P, Toumilehto J, Rastenyte D, Vartianen E (2003) Headache and the risk of stroke. Arch Neurol 163:1058–1062

10.

Schwaag S, Nabavi DG, Frese A, Husstedt IW, Evers S (2003) The association between migraine and juvenile stroke: a case-control study. Headache 43:90–95CrossRefPubMed

11.

Nightingale AL, Farmer RDT (2004) Ischemic stroke in young women a nested case-control study using the UK General Practice research database. Stroke 35:1574–1578CrossRefPubMed

12.

Velentgas P, Cole JA, Mo J (2004) Severe vascular events in migraine patients. Headache 44:642–651CrossRefPubMed

13.

Hall GC, Brown MM, Mo J, MacRae KD (2004) Triptans in migraine: the risks of stroke, cardiovascular disease, and death in practice. Neurology 62:563–568PubMed

14.

Stang FE, Carson AP, Rose KM, Mo J, Ephross SA, Shahar E, Szklo M (2005) Headache, cerebrovascular symptoms, and stroke. The atherosclerosis risk in communities study. Neurology 64:1573–1577CrossRefPubMed

15.

Kurth T, Slomke MA, Kase CS, Cook NR, Lee IM, Gaziano JM, Diener HC, Buring JE (2005) Migraine, headache, and the risk of stroke in women: a prospective study. Neurology 64:1020–1026PubMed

16.

Kurth T, Gaziano MJ, Cook NR, Logroscino GC, Diener HC, Buring JE (2006) Migraine and risk of cardiovascular disease in women. JAMA 296:283–291CrossRefPubMed

17.

MacClellan LR, Giles W, Cole J, Wozniak M, Stern B, Mitchell BD, Kittner SJ (2007) Probable migraine with visual aura and risk of ischemic stroke. The Stroke Prevention in Young Women Study. Stroke 38:2438–2445CrossRefPubMed

18.

Etminan M, Takkouke B, Isorna FC, Samii A (2005) Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies. BMJ 330:63–67CrossRefPubMed

19.

Bousser MG (2004) Estrogen, migraine and stroke. Stroke 35(suppl 1):2652–2656CrossRefPubMed

20.

Diener HC, Kurth T (2005) Editorial: is migraine a risk factor for stroke? Neurology 64:1496–1497CrossRefPubMed

21.

Kurth T (2007) Migraine and ischaemic vascular events. Cephalalgia 27:967–975CrossRef

22.

Silberstein SD (2004) Migraine. Lancet 363:381–391CrossRefPubMed

23.

Camerlingo M, Casto L, Ferraro B, Partziguian T, Gazzaniga GC, Galavotti B, Mamoli A (2000) Recurrence after first cerebral infarction in young adults. Acta Neurol Scand 102:87–93CrossRefPubMed

24.

Bamford J, Sandercock P, Dennis M, Burn J, Warlow C (1991) Classification and natural history of identifiable subtypes of cerebral infarction. Lancet 337:1521–1526CrossRefPubMed

25.

Kappelle LJ, Adams HP Jr, Heffner ML, Torner JC, Gomez F, Biller J (1994) Prognosis of young adults with ischemic stroke. A long-term follow-up study assessing recurrent vascular events and functional outcome in the Iowa registry of stroke in young adults. Stroke 25:1360–1365PubMed

26.

Headache Classification Committee of the International Headache Society (1988) Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia 8 (suppl 7):1–96

27.

Headache Classification SubCommittee of the International Headache Society (2004) The international classification and of headache disorders. Cephalalgia 24 (suppl 1):1–15

28.

Kurth T, Gaziano MJ, Cook NR, Bubes V, Logroscino GC, Diener HC, Buring JE (2007) Migraine and the risk of cardiovascular diseases in men. Arch Intern Med 167:795–801CrossRefPubMed

29.

Lipton RB, Bigal ME, Diamond M, Freitag F, Reed ML, Stewart WF (2007) on behalf of the AMPP Advisory Group. Migraine prevalence, disease burden, and the need for preventive therapy. Neurology 68:343–349CrossRefPubMed

30.

Kruit MC, van Buchem MA, Hofman PAM, Bakkers JTN, Terwindt GM, Ferrari MD, Launer LJ (2004) Migraine as a risk factor for subclinical brain lesions. JAMA 291:427–434CrossRefPubMed

31.

Donaghy M, Chang CL, Poulter N (2002) Duration, frequency, recency, and type of migraine and the risk of ischaemic stroke in women of childbearing age. J Neurol Neurosurg Psychiatry 73:747–750CrossRefPubMed

32.

Tietjen GE (2007) Migraine and ischaemic heart disease and stroke: potential mechanisms and treatment implications. Cephalalgia 27:981–987CrossRefPubMed

33.

Hart RG, Miller VT (1983) Cerebral infarction in young adult: a practical approach. Stroke 14:110–114PubMed

Title: Migraine and cerebral infarction in young people
Authors: Massimo Camerlingo
A. Romorini
C. Ferrante
L. Valente
L. Moschini
Publication date: 01-06-2010
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 3/2010
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-009-0195-7

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Migraine and cerebral infarction in young people

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