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Published in: Clinical Rheumatology 1/2016

Open Access 01-07-2016 | Original Article

Prevalence of musculoskeletal disorders and rheumatic diseases in the indigenous Qom population of Rosario, Argentina

Authors: Rosana Quintana, Adriana M. R. Silvestre, Mario Goñi, Vanina García, Nora Mathern, Marisa Jorfen, Julio Miljevic, Daniel Dhair, Matias Laithe, Silvana Conti, Fadua Midauar, Maria Celeste Martin, Maria Cecilia Barrios, Romina Nieto, Cristina Prigione, Alvaro Sanabria, Viviana Gervasoni, Emilio Grabbe, Romina Gontero, Ingris Peláez-Ballestas, Bernardo A. Pons-Estel

Published in: Clinical Rheumatology | Special Issue 1/2016

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Abstract

This study aimed to estimate the prevalence of musculoskeletal disorders and rheumatic diseases among the indigenous Qom (Toba) population in the city of Rosario, Santa Fe, Argentina. An analytical cross-sectional study using methodology of the Community Oriented Program for the Control of Rheumatic Diseases (COPCORD) was performed. Subjects ≥18 years of age were interviewed by advanced students of medicine and nursing, bilingual translator-facilitators, and coordinators. Individuals with musculoskeletal pain (positive cases) were evaluated sequentially for 7 days by internists and rheumatologists for diagnosis and treatment. The study included 1656 individuals (77 % of the census population). Of these, 1020 (61.5 %) were female, with mean age of 35.3 (SD 13.9) years, and 1028 (62.0 %) were bilingual. The public health care system covers 87.1 % of the population. Musculoskeletal pain in the previous 7 days and/or at some time during their life was present in 890 subjects (53.7 %). Of those with pain in the last 7 days, 302 (64.1 %) subjects had an Health Assessment Questionnaire Disability Index (HAQ-DI) score ≥0.8. The most frequent pain sites were lumbar spine (19.3 %), knees (13.0 %), and hands (12.0 %). The prevalence of rheumatic diseases was as follows: mechanical back pain (20.1 %), rheumatic regional pain syndrome (2.9 %), osteoarthritis (4.0 %) rheumatoid arthritis (2.4 %), inflammatory back pain (0.2 %), systemic sclerosis (0.1 %), Sjögren syndrome (0.1 %), fibromyalgia (0.1 %), mixed connective tissue disease (0.06 %), and systemic lupus erythematosus (0.06 %). The prevalence of musculoskeletal disorders was 53.7 % and rheumatic diseases 29.6 %. Rheumatoid arthritis prevalence was 2.4 % using COPCORD methodology, one of the highest reported at present.
Literature
1.
go back to reference Brooks PM (2006) The burden of musculoskeletal disease—a global perspective. Clin Rheumatol 25:778–781CrossRefPubMed Brooks PM (2006) The burden of musculoskeletal disease—a global perspective. Clin Rheumatol 25:778–781CrossRefPubMed
3.
go back to reference Darmawan J, Muirden KD (2003) WHO-ILAR COPCORD perspectives past, present, and future. J Rheumatol 30:2312–2314PubMed Darmawan J, Muirden KD (2003) WHO-ILAR COPCORD perspectives past, present, and future. J Rheumatol 30:2312–2314PubMed
4.
go back to reference Darmawan J (2007) Recommendations from the Community Oriented Program for Control of Rheumatic Disease for data collection for the measurement and monitoring of health in developing countries. Clin Rheumatol 26:853–857CrossRefPubMed Darmawan J (2007) Recommendations from the Community Oriented Program for Control of Rheumatic Disease for data collection for the measurement and monitoring of health in developing countries. Clin Rheumatol 26:853–857CrossRefPubMed
5.
go back to reference Muirden KD (2005) Community Oriented Program for the Control of Rheumatic Diseases: studies of rheumatic diseases in the developing world. Curr Opin Rheumatol 17:153–156CrossRefPubMed Muirden KD (2005) Community Oriented Program for the Control of Rheumatic Diseases: studies of rheumatic diseases in the developing world. Curr Opin Rheumatol 17:153–156CrossRefPubMed
6.
go back to reference Peláez-Ballestas I, Sanin LH, Moreno-Montoya J, Alvarez-Nemegyei J, Burgos-Vargas R, Garza-Elizondo M et al (2011) Epidemiology of the rheumatic diseases in Mexico. A study of 5 regions based on the COPCORD methodology. J Rheumatol Suppl 86:3–8. doi:10.3899/jrheum.100951 CrossRefPubMed Peláez-Ballestas I, Sanin LH, Moreno-Montoya J, Alvarez-Nemegyei J, Burgos-Vargas R, Garza-Elizondo M et al (2011) Epidemiology of the rheumatic diseases in Mexico. A study of 5 regions based on the COPCORD methodology. J Rheumatol Suppl 86:3–8. doi:10.​3899/​jrheum.​100951 CrossRefPubMed
7.
go back to reference Obregon-Ponce A, Iraheta I, Garcıa-Ferrer H, Mejia B, Garcıa-Kutzbach A (2012) Prevalence of musculoskeletal diseases in Guatemala, Central America: the COPCORD study of 2 population. J Clin Rheumatol 18(4):170–174. doi:10.1097/RHU.0b013e3182583803 PubMed Obregon-Ponce A, Iraheta I, Garcıa-Ferrer H, Mejia B, Garcıa-Kutzbach A (2012) Prevalence of musculoskeletal diseases in Guatemala, Central America: the COPCORD study of 2 population. J Clin Rheumatol 18(4):170–174. doi:10.​1097/​RHU.​0b013e3182583803​ PubMed
8.
go back to reference Reyes-Llerena GA, Guibert-Toledano M, Penedo-Coello A, Perez-Rodriguez A, Baez-Duenas RM, Charchinaro-Vidal R et al (2009) Community-based study to estimate prevalence and burden of illness of rheumatic diseases in Cuba: a COPCORD study. J Clin Rheumatol 15:51–55. doi:10.1097/RHU.0b013e31819b61cb CrossRefPubMed Reyes-Llerena GA, Guibert-Toledano M, Penedo-Coello A, Perez-Rodriguez A, Baez-Duenas RM, Charchinaro-Vidal R et al (2009) Community-based study to estimate prevalence and burden of illness of rheumatic diseases in Cuba: a COPCORD study. J Clin Rheumatol 15:51–55. doi:10.​1097/​RHU.​0b013e31819b61cb​ CrossRefPubMed
9.
go back to reference Gamboa R, Medina M, Acevedo E, Pastor C, Cucho M, Gutierrez C et al (2009) Prevalence of rheumatic diseases and disability in an urban marginal Latin American population. A community based study using the COPCORD model. Rev Peru Reumatol 15:40–46 Gamboa R, Medina M, Acevedo E, Pastor C, Cucho M, Gutierrez C et al (2009) Prevalence of rheumatic diseases and disability in an urban marginal Latin American population. A community based study using the COPCORD model. Rev Peru Reumatol 15:40–46
10.
go back to reference Granados Y, Cedeño L, Rosillo C, Berbin S, Azocar M, Molina ME et al. (2014) Prevalence of musculoskeletal disorders and rheumatic diseases in an urban community in Monagas State, Venezuela: a COPCORD study. Clin Rheumatol Granados Y, Cedeño L, Rosillo C, Berbin S, Azocar M, Molina ME et al. (2014) Prevalence of musculoskeletal disorders and rheumatic diseases in an urban community in Monagas State, Venezuela: a COPCORD study. Clin Rheumatol
11.
go back to reference Rodríguez-Senna E, De Barros LP, Silva EO, Costa IF, Pereira LV, Mesquita-Ciconelli R et al (2004) Prevalence of rheumatic diseases in Brazil: a study using the COPCORD approach. J Rheumatol 31:594–597 Rodríguez-Senna E, De Barros LP, Silva EO, Costa IF, Pereira LV, Mesquita-Ciconelli R et al (2004) Prevalence of rheumatic diseases in Brazil: a study using the COPCORD approach. J Rheumatol 31:594–597
12.
go back to reference Montenegro RA, Stephens C (2006) Indigenous health in Latin America and the Caribbean. Lancet 3(9525):1859–1869CrossRef Montenegro RA, Stephens C (2006) Indigenous health in Latin America and the Caribbean. Lancet 3(9525):1859–1869CrossRef
13.
go back to reference Pons-Estel BA, Catoggio LJ, Cardiel MH, Soriano ER, Gentiletti S, Villa AR et al (2004) The GLADEL multinational Latin American prospective inception cohort of 1,214 patients with systemic lupus erythematosus: ethnic and disease heterogeneity among “Hispanics”. Medicine 83:1–17CrossRefPubMed Pons-Estel BA, Catoggio LJ, Cardiel MH, Soriano ER, Gentiletti S, Villa AR et al (2004) The GLADEL multinational Latin American prospective inception cohort of 1,214 patients with systemic lupus erythematosus: ethnic and disease heterogeneity among “Hispanics”. Medicine 83:1–17CrossRefPubMed
14.
go back to reference Cardiel MH, Pons-Estel BA, Sacnun MP, Wojdyla D, Saurit V, Marcos JC et al (2012) Treatment of early rheumatoid arthritis in a multinational inception cohort of Latin American patients: the GLADAR experience. J Clin Rheumatol 18:327–335. doi:10.1097/RHU.0b013e31826d6610 CrossRefPubMed Cardiel MH, Pons-Estel BA, Sacnun MP, Wojdyla D, Saurit V, Marcos JC et al (2012) Treatment of early rheumatoid arthritis in a multinational inception cohort of Latin American patients: the GLADAR experience. J Clin Rheumatol 18:327–335. doi:10.​1097/​RHU.​0b013e31826d6610​ CrossRefPubMed
15.
go back to reference Massardo L, Pons-Estel BA, Wojdyla D, Cardiel MH, Galarza-Maldonado CM, Sacnun MP et al (2012) Early rheumatoid arthritis in Latin America: low socioeconomic status related to high disease activity at baseline. Arthritis Care Res (Hoboken) 64(8):1135–1143. doi:10.1002/acr.21680 Massardo L, Pons-Estel BA, Wojdyla D, Cardiel MH, Galarza-Maldonado CM, Sacnun MP et al (2012) Early rheumatoid arthritis in Latin America: low socioeconomic status related to high disease activity at baseline. Arthritis Care Res (Hoboken) 64(8):1135–1143. doi:10.​1002/​acr.​21680
16.
go back to reference Pons-Estel GJ, Alarcón GS, Hachuel L, Boggio G, Wojdyla D, Pascual-Ramos V et al (2012) Anti-malarials exert a protective effect while Mestizo patients are at increased risk of developing SLE renal disease: data from a Latin-American cohort. Rheumatology (Oxford) 51(7):1293–1298. doi:10.1093/rheumatology/ker514 CrossRef Pons-Estel GJ, Alarcón GS, Hachuel L, Boggio G, Wojdyla D, Pascual-Ramos V et al (2012) Anti-malarials exert a protective effect while Mestizo patients are at increased risk of developing SLE renal disease: data from a Latin-American cohort. Rheumatology (Oxford) 51(7):1293–1298. doi:10.​1093/​rheumatology/​ker514 CrossRef
19.
go back to reference Peláez-Ballestas I, Granados Y, Silvestre A, Alvarez-Nemegyei J, Valls E, Quintana R et al (2014) Culture-sensitive adaptation and validation of the Community-Oriented Program for the Control of Rheumatic Diseases methodology for rheumatic disease in Latin American indigenous populations. Rheumatol Int 34(9):1299–1309. doi:10.1007/s00296-014-2997-z CrossRefPubMed Peláez-Ballestas I, Granados Y, Silvestre A, Alvarez-Nemegyei J, Valls E, Quintana R et al (2014) Culture-sensitive adaptation and validation of the Community-Oriented Program for the Control of Rheumatic Diseases methodology for rheumatic disease in Latin American indigenous populations. Rheumatol Int 34(9):1299–1309. doi:10.​1007/​s00296-014-2997-z CrossRefPubMed
20.
go back to reference Goycochea-Robles MV, Sanin LH, Moreno-Montoya J, Alvarez-Nemegyei J, Burgos-Vargas R, Garza-Elizondo M et al (2011) Grupo de Estudio Epidemiológico de Enfermedades Músculo Articulares (GEEMA) (2011) Validity of the COPCORD core questionnaire as a classification tool for rheumatic diseases. J Rheumatol Suppl 86:31–35CrossRefPubMed Goycochea-Robles MV, Sanin LH, Moreno-Montoya J, Alvarez-Nemegyei J, Burgos-Vargas R, Garza-Elizondo M et al (2011) Grupo de Estudio Epidemiológico de Enfermedades Músculo Articulares (GEEMA) (2011) Validity of the COPCORD core questionnaire as a classification tool for rheumatic diseases. J Rheumatol Suppl 86:31–35CrossRefPubMed
21.
go back to reference Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS et al (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315–324CrossRefPubMed Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS et al (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315–324CrossRefPubMed
22.
go back to reference Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40:1725CrossRefPubMed Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40:1725CrossRefPubMed
23.
go back to reference van den Hoogen F, Khanna D, Fransen J, Johnson SR, Baron M, Tyndall A et al (2013) 2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis 72(11):1747–1755. doi:10.1136/annrheumdis-2013-204424 CrossRefPubMed van den Hoogen F, Khanna D, Fransen J, Johnson SR, Baron M, Tyndall A et al (2013) 2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis 72(11):1747–1755. doi:10.​1136/​annrheumdis-2013-204424 CrossRefPubMed
24.
go back to reference Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE et al (2002) Classification criteria for Sjogren’s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 61:554–558CrossRefPubMedPubMedCentral Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE et al (2002) Classification criteria for Sjogren’s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 61:554–558CrossRefPubMedPubMedCentral
25.
go back to reference Sharp GC, Irvin WS, Tan EM, Gould RG, Holman HR (1972) Mixed connective tissue disease—an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA). Am J Med 52(2):148–159CrossRefPubMed Sharp GC, Irvin WS, Tan EM, Gould RG, Holman HR (1972) Mixed connective tissue disease—an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA). Am J Med 52(2):148–159CrossRefPubMed
26.
go back to reference Rudwaleit M, Metter A, Listing J, Sieper J, Braun J (2006) Inflammatory back pain in ankylosing spondylitis: a reassessment of the clinical history for application as classification and diagnostic criteria. Arthritis Rheum 54:569–578CrossRefPubMed Rudwaleit M, Metter A, Listing J, Sieper J, Braun J (2006) Inflammatory back pain in ankylosing spondylitis: a reassessment of the clinical history for application as classification and diagnostic criteria. Arthritis Rheum 54:569–578CrossRefPubMed
27.
go back to reference Altman R, Alarcón G, Appelrouth D, Bloch D, Borenstein D, Brandt K et al (1990) The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hand. Arthritis Rheum 33:1601–1610CrossRefPubMed Altman R, Alarcón G, Appelrouth D, Bloch D, Borenstein D, Brandt K et al (1990) The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hand. Arthritis Rheum 33:1601–1610CrossRefPubMed
28.
go back to reference Dougados M, van der Linden S, Juhlin R, Huitfeldt B, Amor B, Calin A et al (1991) The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy. Arthritis Rheum 34:1218–1227CrossRefPubMed Dougados M, van der Linden S, Juhlin R, Huitfeldt B, Amor B, Calin A et al (1991) The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy. Arthritis Rheum 34:1218–1227CrossRefPubMed
29.
go back to reference Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL et al (1990) The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 33:160–172CrossRefPubMed Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL et al (1990) The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 33:160–172CrossRefPubMed
30.
go back to reference Alvarez-Nemegyei J, Peláez-Ballestas I, Rodríguez-Amado J, Sanin LH, Garcia-Garcia C, Garza-Elizondo MA et al (2011) Prevalence of rheumatic regional pain syndromes in adults from Mexico: a community survey using COPCORD for screening and syndrome-specific diagnostic criteria. J Rheumatol Suppl 86:15–20. doi:10.3899/jrheum.100953 CrossRefPubMed Alvarez-Nemegyei J, Peláez-Ballestas I, Rodríguez-Amado J, Sanin LH, Garcia-Garcia C, Garza-Elizondo MA et al (2011) Prevalence of rheumatic regional pain syndromes in adults from Mexico: a community survey using COPCORD for screening and syndrome-specific diagnostic criteria. J Rheumatol Suppl 86:15–20. doi:10.​3899/​jrheum.​100953 CrossRefPubMed
31.
go back to reference Peláez-Ballestas I, Flores-Camacho R, Rodriguez-Amado J, Sanin LE, Esquivel VJ, Navarro-Zarza E et al (2011) Prevalence of back pain in the community. A COPCORD based study in the Mexican population. J Rheumatol Suppl 86:26–30. doi:10.3899/jrheum.101035 CrossRefPubMed Peláez-Ballestas I, Flores-Camacho R, Rodriguez-Amado J, Sanin LE, Esquivel VJ, Navarro-Zarza E et al (2011) Prevalence of back pain in the community. A COPCORD based study in the Mexican population. J Rheumatol Suppl 86:26–30. doi:10.​3899/​jrheum.​101035 CrossRefPubMed
32.
go back to reference The ICD-10 international statistical classification of diseases and related health problems: 10th revision. 2nd ed. Geneva: World Health Organization; 2004 The ICD-10 international statistical classification of diseases and related health problems: 10th revision. 2nd ed. Geneva: World Health Organization; 2004
33.
go back to reference Minaur N, Sawyers S, Parker J, Darmawan J (2004) Rheumatic disease in an Australian Aboriginal community in North Queensland, Australia. A WHO-ILAR COPCORD survey. Survey J Rheumatol 31:965–972PubMed Minaur N, Sawyers S, Parker J, Darmawan J (2004) Rheumatic disease in an Australian Aboriginal community in North Queensland, Australia. A WHO-ILAR COPCORD survey. Survey J Rheumatol 31:965–972PubMed
35.
go back to reference Ferucci ED, Templin DW, Lanier AP (2005) Rheumatoid arthritis in American Indians and Alaska Natives: a review of the literature. Semin Arthritis Rheum 34:662–667CrossRefPubMed Ferucci ED, Templin DW, Lanier AP (2005) Rheumatoid arthritis in American Indians and Alaska Natives: a review of the literature. Semin Arthritis Rheum 34:662–667CrossRefPubMed
36.
go back to reference Barnabe C, Elias B, Bartlett J, Roos L, Barnabe Cherly PC (2008) Arthritis in aboriginal manitobans: evidence for a high burden of disease. J Rheumatol 35:1145–1150PubMed Barnabe C, Elias B, Bartlett J, Roos L, Barnabe Cherly PC (2008) Arthritis in aboriginal manitobans: evidence for a high burden of disease. J Rheumatol 35:1145–1150PubMed
37.
go back to reference Spindler A, Bellomio V, Berman A, Lucero E, Baigorria M, Paz S et al (2002) Prevalence of rheumatoid arthritis in Tucumán, Argentina. J Rheumatol 29(6):1166–1170PubMed Spindler A, Bellomio V, Berman A, Lucero E, Baigorria M, Paz S et al (2002) Prevalence of rheumatoid arthritis in Tucumán, Argentina. J Rheumatol 29(6):1166–1170PubMed
38.
go back to reference Scublinsky D, Venarotti H, Citera G, Messina OD, Scheines E, Rillo O et al (2010) The prevalence of rheumatoid arthritis in Argentina: a capture-recapture study in a city of Buenos Aires province. J Clin Rheumatol 16(7):317–321. doi:10.1097/RHU.0b013e3181f3bfdd PubMed Scublinsky D, Venarotti H, Citera G, Messina OD, Scheines E, Rillo O et al (2010) The prevalence of rheumatoid arthritis in Argentina: a capture-recapture study in a city of Buenos Aires province. J Clin Rheumatol 16(7):317–321. doi:10.​1097/​RHU.​0b013e3181f3bfdd​ PubMed
40.
41.
go back to reference Davatchi F, Tehrani Banihashemi A, Gholami J, Faezi ST, Forouzanfar MH, Salesi M et al (2009) The prevalence of musculoskeletal complaints in a rural area in Iran: a WHO-ILAR COPCORD study (stage 1, rural study) in Iran. Clin Rheumatol 28(11):1267–1274. doi:10.1007/s10067-009-1234-8 CrossRefPubMed Davatchi F, Tehrani Banihashemi A, Gholami J, Faezi ST, Forouzanfar MH, Salesi M et al (2009) The prevalence of musculoskeletal complaints in a rural area in Iran: a WHO-ILAR COPCORD study (stage 1, rural study) in Iran. Clin Rheumatol 28(11):1267–1274. doi:10.​1007/​s10067-009-1234-8 CrossRefPubMed
44.
go back to reference Toloza SM, Vega-Hinojosa O, Chandran V, Valle Onate R, Espinoza LR (2012) Psoriasis and psoriatic arthritis in Peruvian aborigines: a report from the GRAPPA 2011 annual meeting. J Rheumatol 39:2216–2219. doi:10.3899/jrheum.120828 CrossRefPubMed Toloza SM, Vega-Hinojosa O, Chandran V, Valle Onate R, Espinoza LR (2012) Psoriasis and psoriatic arthritis in Peruvian aborigines: a report from the GRAPPA 2011 annual meeting. J Rheumatol 39:2216–2219. doi:10.​3899/​jrheum.​120828 CrossRefPubMed
Metadata
Title
Prevalence of musculoskeletal disorders and rheumatic diseases in the indigenous Qom population of Rosario, Argentina
Authors
Rosana Quintana
Adriana M. R. Silvestre
Mario Goñi
Vanina García
Nora Mathern
Marisa Jorfen
Julio Miljevic
Daniel Dhair
Matias Laithe
Silvana Conti
Fadua Midauar
Maria Celeste Martin
Maria Cecilia Barrios
Romina Nieto
Cristina Prigione
Alvaro Sanabria
Viviana Gervasoni
Emilio Grabbe
Romina Gontero
Ingris Peláez-Ballestas
Bernardo A. Pons-Estel
Publication date
01-07-2016
Publisher
Springer London
Published in
Clinical Rheumatology / Issue Special Issue 1/2016
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-016-3192-2

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