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01-09-2013 | Original Article

Effects of 15 consecutive cryotherapy sessions on the clinical output of fibromyalgic patients

Authors: Lorenzo Bettoni, Felice Giulio Bonomi, Viviana Zani, Luigia Manisco, Annamaria Indelicato, Patrizia Lanteri, Giuseppe Banfi, Giovanni Lombardi

Published in: Clinical Rheumatology | Issue 9/2013

Abstract

Fibromyalgia is a chronic widespread pain disorder in which, the neurogenic origin of the pain, featured by allodynia and hyperalgesia, results from an imbalance in the levels of neurotransmitters and consequently of the peripheral pro- and anti-inflammatory mediators. Whole body cryotherapy is a peculiar physical therapy known to relieve pain and inflammatory symptoms characteristics of rheumatic diseases, through the regulation of the cytokine expression. The aim of this study was to qualitatively evaluate the effects of cryotherapy on the clinical output of fibromyalgic patients. A total of 100 fibromyalgic patients (age range 17–70 years) were observed; 50 subjects were addressed to cryotherapy, while the second group (n = 50) did not underwent to the cryotherapic treatment. All subjects kept the prescribed pharmacological therapy during the study (analgesic and antioxidants). The referred health status pre- and post-observation was evaluated with the following scales: Visual Analogue Scale, Short Form-36, Global Health Status and Fatigue Severity Scale. Fibromyalgic patients treated with cryotherapy reported a more pronounced improvement of the quality of life, in comparison with the non-cryo treated fibromyalgic subjects, as indicated by the scores of the qualitative indexes and sub-indexes, that are widely recognized tools to assess the overall health status and the effect of the treatments. We speculate that this improvement is due to the known direct effect of cryotherapy on the balance between pro- and anti-inflammatory mediators having a recognized role in the modulation of pain.

Arnold LM, Clauw DJ, Dunegan LJ, Turk DC (2012) A framework for fibromyalgia management for primary care providers. Mayo Clin Proc 87(5):488–496. doi:1016/j.mayocp.2012.02.010 PubMedCrossRef

Clauw DJ, Arnold LM, McCarberg BH (2011) The science of fibromyalgia. Mayo Clin Proc 86(9):907–911. doi:10.4065/mcp.2011.0206 PubMedCrossRef

Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Katz RS, Mease P, Russell AS, Russell IJ, Winfield JB, Yunus MB (2010) The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res (Hoboken) 62(5):600–610. doi:10.1002/acr.20140 CrossRef

McBeth J, Mulvey MR (2012) Fibromyalgia: mechanisms and potential impact of the ACR 2010 classification criteria. Nat Rev Rheumatol 8(2):108–116. doi:10.1038/nrrheum.2011.216 PubMed

Gracely RH, Petzke F, Wolf JM, Clauw DJ (2002) Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia. Arthritis Rheum 46(5):1333–1343. doi:10.1002/art.10225 PubMedCrossRef

Ablin K, Clauw DJ (2009) From fibrositis to functional somatic syndromes to a bell-shaped curve of pain and sensory sensitivity: evolution of a clinical construct. Rheum Dis Clin North Am 35(2):233–251. doi:10.1016/j.rdc.2009.06.006 PubMedCrossRef

Seidel MF, Herguijuela M, Forkert R, Otten U (2010) Nerve growth factor in rheumatic diseases. Semin Arthritis Rheum 40(2):109–126. doi:10.1016/j.semarthrit.2009.03.002 PubMedCrossRef

Bazzichi L, Rossi A, Massimetti G, Giannaccini G, Giuliano T, De Feo F, Ciapparelli A, Dell'Osso L, Bombardieri S (2007) Cytokine patterns in fibromyalgia and their correlation with clinical manifestations. Clin Exp Rheumatol 25(2):225–230PubMed

Sarzi-Puttini P, Atzeni F, Mease PJ (2011) Chronic widespread pain: from peripheral to central evolution. Best Pract Res Clin Rheumatol 25(2):133–139. doi:10.1016/j.berh.2011.04.001 PubMedCrossRef

10.

Marques AP, Ferreira EA, Matsutani LA, Pereira CA, Assumpcao A (2005) Quantifying pain threshold and quality of life of fibromyalgia patients. Clin Rheumatol 24(3):266–271. doi:10.1007/s10067-004-1003-7 PubMedCrossRef

11.

Banfi G, Lombardi G, Colombini A, Melegati G (2010) Whole-body cryotherapy in athletes. Sports Med 40(6):509–517. doi:10.2165/11531940-000000000-000005 PubMedCrossRef

12.

Fricke R (1989) Ganzokorpekaltetherapie in einer Kaltekammer mit Temperaturen um −110 °C. Z PhysMed Baln Med Klim 18:1–10

13.

Smolander J, Westerlund T, Uusitalo A, Dugue B, Oksa J, Mikkelsson M (2006) Lung function after acute and repeated exposures to extremely cold air (−110 degrees C) during whole-body cryotherapy. Clin Physiol Funct Imaging 26(4):232–234. doi:10.1111/j.1475-097X.2006.00675.x PubMedCrossRef

14.

Bonomi FG, De Nardi M, Fappani A, Zani V, Banfi G (2012) Impact of different treatment of whole-body cryotherapy on circulatory parameters. Arch Immunol Ther Exp (Warsz) 60(2):145–150. doi:10.1007/s00005-012-0163-4 CrossRef

15.

Mease PJ, Dundon K, Sarzi-Puttini P (2011) Pharmacotherapy of fibromyalgia. Best Pract Res Clin Rheumatol 25(2):285–297. doi:10.1016/j.berh.2011.01.015 PubMedCrossRef

16.

Hassett AL, Williams DA (2011) Non-pharmacological treatment of chronic widespread musculoskeletal pain. Best Pract Res Clin Rheumatol 25(2):299–309. doi:10.1016/j.berh.2011.01.005 PubMedCrossRef

17.

Walsh NP, Whitham M (2006) Exercising in environmental extremes : a greater threat to immune function? Sports Med 36(11):941–976PubMedCrossRef

18.

Jansky L, Pospisilova D, Honzova S, Ulicny B, Sramek P, Zeman V, Kaminkova J (1996) Immune system of cold-exposed and cold-adapted humans. Eur J Appl Physiol Occup Physiol 72(5–6):445–450PubMedCrossRef

19.

Lubkowska A, Szyguła Z, Klimek A, Torii M (2010) Do sessions of cryostimulation have influence on white blood cells count, level of IL6 and the total oxidative and antioxidative status in healthy men. Eur J Appl Physiol 109(1):67–72PubMedCrossRef

20.

Lubkowska A, Szyguła Z, Chlubek D, Banfi G (2011) The effect of prolonged whole-body cryostimulation treatment with different amounts of sessions on chosen pro- and anti-inflammatory cytokines in healthy men. Scand J Clin Lab Invest 71(5):419–425PubMedCrossRef

21.

Offenbacher M, Stucki G (2000) Physical therapy in the treatment of fibromyalgia. Scand J Rheumatol Suppl 113:78–85PubMed

22.

Samborski W, Stratz T, Sobieska M, Mennet P, Muller W, Schulte-Monting J (1992) Intraindividual comparison of whole body cold therapy and warm treatment with hot packs in generalized tendomyopathy. Z Rheumatol 51(1):25–30PubMed

23.

Gutenbrunner C, Englert G, Neues-Lahusen M, Gehrke A (1999) Analgetic effects of natural sulphur baths and coldchamber expositions in Fibromyalgia. Phys Rehab Kur Med 9:56–62CrossRef

24.

Bijur PE, Silver W, Gallagher EJ (2001) Reliability of the visual analog scale for measurement of acute pain. Acad Emerg Med 8(12):1153–1157PubMedCrossRef

25.

Ware JE Jr (2000) SF-36 health survey update. Spine (Phila Pa 1976) 25(24):3130–3139CrossRef

26.

Villaverde V, Balsa A, Cantalejo M, Fernandez-Prada M, Madero MR, Munoz-Fernandez S, Gijon-Banos J, Martin-Mola E (2000) Activity indices in rheumatoid arthritis. J Rheumatol 27(11):2576–2581PubMed

27.

Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD (1989) The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus Arch Neurol 46(10):1121–1123

28.

Russell IJ, Larson AA (2009) Neurophysiopathogenesis of fibromyalgia syndrome: a unified hypothesis. Rheum Dis Clin North Am 35(2):421–435. doi:10.1016/j.rdc.2009.06.005 PubMedCrossRef

29.

Williams DA, Clauw DJ (2009) Understanding fibromyalgia: lessons from the broader pain research community. J Pain 10(8):777–791. doi:10.1016/j.jpain.2009.06.001 PubMedCrossRef

30.

Cazzola M, Sarzi-Puttini P, Stisi S, Di Franco M, Bazzichi L, Carignola R, Gracely RH, Salaffi F, Marinangeli F, Torta R, Giamberardino MA, Buskila D, Spath M, Biasi G, Cassisi G, Casale R, Altomonte L, Arioli G, Alciati A, Marsico A, Ceccherelli F, Leardini G, Gorla R, Atzeni F (2008) Italian fibromyalgia network. Fibromyalgia syndrome: definition and diagnostic aspects. Reumatismo 60(suppl 1):3–14PubMed

31.

Stisi S, Cazzola M, Buskila D, Spath M, Giamberardino MA, Sarzi-Puttini P, Arioli G, Alciati A, Leardini G, Gorla R, Marsico M, Ceccherelli F, Bazzichi L, Carignola R, Gracely RH, Salaffi F, Altomonte L, Atzeni F (2008) Italian fibromyalgia network. Etiopathogenetic mechanisms of fibromyalgia syndrome. Reumatismo 60(suppl 1):25–35PubMed

32.

Staud R (2009) Abnormal pain modulation in patients with spatially distributed chronic pain: fibromyalgia. Rheum Dis Clin North Am 35(2):263–274. doi:10.1016/j.rdc.2009.05.006 PubMedCrossRef

33.

Uceyler N, Sommer C (2008) Cytokine regulation in animal models of neuropathic pain and in human diseases. Neurosci Lett 437(3):194–198. doi:10.1016/j.neulet.2008.03.050 PubMedCrossRef

34.

Wallace DJ, Linker-Israeli M, Hallegua D, Silverman S, Silver D, Weisman MH (2001) Cytokines play an aetiopathogenetic role in fibromyalgia: a hypothesis and pilot study. Rheumatology (Oxford) 40(7):743–749CrossRef

35.

Uceyler N, Hauser W, Sommer C (2011) Systematic review with meta-analysis: cytokines in fibromyalgia syndrome. BMC Musculoskelet Disord 12:245. doi:10.1186/1471-2474-12-245 PubMedCrossRef

36.

Algafly AA, George KP (2007) The effect of cryotherapy on nerve conduction velocity, pain threshold and pain tolerance. Br J Sports Med 41(6):365–369. doi:10.1136/bjsm.2006.031237 PubMedCrossRef

37.

Cohen H, Alferiev IS, Mönkkönen J, Seibel MJ, Pinto T, Ezra A, Solomon V, Stepensky D, Sagi H, Ornoy A, Patlas N, Hägele G, Hoffman A, Breuer E, Golomb G (1999) Synthesis and preclinical pharmacology of 2-(2-aminopyrimidinio) ethylidene-1,1-bisphosphonic acid betaine (ISA-13-1)-a novel bisphosphonate. Pharm Res 16(9):1399–1406PubMedCrossRef

38.

Oude Voshaar MA, ten Klooster PM, Taal E, van de Laar MA (2011) Measurement properties of physical function scales validated for use in patients with rheumatoid arthritis: a systematic review of the literature. Health Qual Life Outcomes 9:99. doi:10.1186/1477-7525-9-99 PubMedCrossRef

39.

Hoffman DL, Dukes EM (2008) The health status burden of people with fibromyalgia: a review of studies that assessed health status with the SF-36 or the SF-12. Int J Clin Pract 62(1):115–126. doi:10.1111/j.1742-1241.2007.01638.x PubMedCrossRef

40.

Casale R, Rainoldi A (2011) Fatigue and fibromyalgia syndrome: clinical and neurophysiologic pattern. Best Pract Res Clin Rheumatol 25(2):241–247. doi:10.1016/j.berh.2011.01.016 PubMedCrossRef

Title: Effects of 15 consecutive cryotherapy sessions on the clinical output of fibromyalgic patients
Authors: Lorenzo Bettoni
Felice Giulio Bonomi
Viviana Zani
Luigia Manisco
Annamaria Indelicato
Patrizia Lanteri
Giuseppe Banfi
Giovanni Lombardi
Publication date: 01-09-2013
Publisher: Springer London
Published in: Clinical Rheumatology / Issue 9/2013
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-013-2280-9

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