Published in:
01-10-2007 | Brief Report
Expression of CD22 on peripheral B cells in patients with rheumatoid arthritis: relation to CD5-positive B cells
Authors:
Yutaka Nakiri, Kentarou Minowa, Jun Suzuki, Akiko Mitsuo, Hirofumi Amano, Shinji Morimoto, Yoshiaki Tokano, Yoshinari Takasaki
Published in:
Clinical Rheumatology
|
Issue 10/2007
Login to get access
Abstract
B cells in patients with rheumatoid arthritis (RA) are hyperactivated. Although B cell receptor signal transduction may be affected by various response regulators, CD22 plays an important role as a response regulator of B cells. Therefore, we investigated and examined CD22 expression on peripheral blood B cells of patients with RA. Thirty-two RA patients and 16 controls were enrolled in this study, and CD22 expressions on B cells were analyzed by flow cytometry. In patients with RA, CD22+ B cells significantly decreased in comparison to the controls (ratio: P < 0.05). However, there was no correlation between this decrease and the clinical data. Interestingly, CD5+ CD22− B cells significantly increased in RA patients. The decrease in CD22+ B cells and increased in CD5+CD22− B cells play critical roles in the pathogenesis of RA mediated by the activation of B cells.