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Clinical Rheumatology
Published in: Clinical Rheumatology 6/2004

01-12-2004 | Letter

Pulmonary coinfection by Pneumocystis carinii and Aspergillus fumigatus in a seronegative arthritis patient treated with low-dose methotrexate

Authors: M. Mariñosa, A. Soler, X. Nogués, J. Pedro-Botet

Published in: Clinical Rheumatology | Issue 6/2004

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Excerpt

Low-dose methotrexate is widely used in the treatment of rheumatologic and cutaneous diseases such as rheumatoid arthritis and psoriasis. Opportunistic infections associated with this immunosuppressive therapy are increasingly recognized. In this respect, Pneumocystis carinii pneumonia has been the most prevalently reported infection [1] and a case of Aspergillus fumigatus pulmonary infection has been described [2]. The first case of pulmonary coinfection by Pneumocystis carinii and Aspergillus fumigatus, both community acquired, in a patient with low-dose methotrexate-treated seronegative arthritis is presented. …
Literature
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Lemense GP, Sahn SA (1994) Opportunistic infection during treatment with low dose methotrexate. Am J Respir Crit Care Med 150:258–260
2.
O’Reilly S, Hartley P, Jeffers M, Casey E, Clancy L (1994) Invasive pulmonary aspergillosis associated with low dose methotrexate therapy for rheumatoid arthritis: a case report of treatment with itraconazole. Tuber Lung Dis 75:153–155CrossRefPubMed
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Godeau B, Coutant-Perronne V, Le Thi Huong D et al. (1994) Pneumocystis carinii pneumonia in the course of connective tissue disease: report of 34 cases. J Rheumatol 21:246–251PubMed
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Krebs S, Gibbons RB (1996) Low-dose methotrexate as a risk factor for Pneumocystis carinii pneumonia. Mil Med 161:58–60PubMed
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Roux N, Flipo RM, Cortet B et al (1996) Pneumocystis carinii pneumonia in rheumatoid arthritis patients treated with methotrexate. A report of two cases. Rev Rhum Engl Ed 63:453–456PubMed
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Mansharamani NG, Garland R, Delaney D, Koziel H (2000) Management and outcome patterns for adult Pneumocystis carinii pneumonia, 1985 to 1995. Comparison of HIV-associated cases to other immunocompromised states. Chest 118:704–711CrossRefPubMed
Metadata
Title
Pulmonary coinfection by Pneumocystis carinii and Aspergillus fumigatus in a seronegative arthritis patient treated with low-dose methotrexate
Authors
M. Mariñosa
A. Soler
X. Nogués
J. Pedro-Botet
Publication date
01-12-2004
Publisher
Springer-Verlag
Published in
Clinical Rheumatology / Issue 6/2004
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-004-0900-0

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