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Clinical Rheumatology
Published in: Clinical Rheumatology 6/2003

01-12-2003 | Case Report

Alkaptonuric ochronosis: a case with multiple joint replacement arthroplasties

Author: Serap Demir

Published in: Clinical Rheumatology | Issue 6/2003

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Abstract

Alkaptonuria is an extremely rare hereditary disorder of metabolism which may affect various systems. Degeneration of the articular surfaces in major joints leads to complications, which may further necessitate joint replacements. In this report, a case of advanced alkaptonuria with multiple joint replacements is presented and musculoskeletal system involvement in this disorder is reviewed.
Literature
1.
Paul R, Ylinen SL (1991) The “whisker sign” as an indicator of ochronosis in skeletal scintigraphy. Eur J Nucl Med 18:222–224PubMed
2.
Touart DM, Sau P (1998) Cutaneous deposition diseases. Part II. J Am Acad Dermatol 39:527–544PubMed
3.
Fernandez-Canon JM, Granadino B, Beltran-Valero de Bernabe D et al. (1996) The molecular basis of alkaptonuria. Nature Genet 14:19–24PubMed
4.
Gutzmer R, Herbst RA, Kiehl P, Kapp A, Weiss J (1997) Alcaptonuric ochronosis: Report of two affected brothers. J Am Acad Dermatol 37:305–307PubMed
5.
Hamdi N, Cooke TDV, Hassan B (1999) Ochronotic arthropathy: case report and review of the literature. Int Orthop 23:122–125PubMed
6.
Cheskes J, Buettner H (2000) Ocular manifestations of alkaptonuric ochronosis. Arch Ophthalmol 118:724–725PubMed
7.
Garcia SF, Egbert B, Swetter SM (1999) Hereditary ochronosis: hyperpigmented skin overlying cartilaginous structures. Cutis 63:337–338PubMed
8.
Emel E, Karagöz F, Aydın H, Hacısalihoğlu S, Seyithanoğlu H (2000) Alkaptonuria with lumbar disc herniation. A report of two cases. Spine 25:2141–2144CrossRefPubMed
9.
Gaines JJ Jr (1989) The pathology of alkaptonuric ochronosis. Hum Pathol 20:40–46PubMed
10.
Di Franco M, Coari G, Bonucci E (2000) A morphological study of bone and articular cartilage in ochronosis. Virchows Arch 436:74–81PubMed
11.
Selvi E, Manganelli S, Benucci M, Marcolongo R (2000) Chronic ochronotic arthritis: clinical, arthroscopic, and pathologic findings. J Rheumatol 27:2272–2274PubMed
12.
Lagier R, Sit’aj S (1974) Vertebral changes in ochronosis. Anatomical and radiological study of one case. Ann Rheum Dis 33:86–92PubMed
13.
Orzincolo C, Castaldi G, Scutellari PN, Cicognani P, Bariani L, Feggi L (1988) Ochronotic arthropathy in alkaptonuria. Radiological manifestations and physiopathological signs. Radiol Med 75:476–481
14.
Carrier DA, Harris CM (1990) Bilateral hip and bilateral knee joint artroplasties in a patient with ochronotic arthropathy. Orthop Rev 19:1005–1009PubMed
Metadata
Title
Alkaptonuric ochronosis: a case with multiple joint replacement arthroplasties
Author
Serap Demir
Publication date
01-12-2003
Publisher
Springer-Verlag
Published in
Clinical Rheumatology / Issue 6/2003
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-003-0760-z

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