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01-04-2009 | Short Communication

LRRK2 G2019S and R1441G mutations associated with Parkinson’s disease are common in the Basque Country, but relative prevalence is determined by ethnicity

Authors: A. Gorostidi, J. Ruiz-Martínez, A. Lopez de Munain, A. Alzualde, J. F. Martí Massó

Published in: Neurogenetics | Issue 2/2009

Abstract

Mutations in LRRK2 gene are the most frequent cause of Parkinson’s disease (PD) described, but their prevalence varies between populations. Patients, 418, with PD and 138 unrelated controls from the Basque Country were screened for LRRK2 G2019S and R1441G mutations. Of the patients, 3.82% were heterozygous carriers of G2019S and 13.15% of R1441G. G2019S frequency was higher in non-Basque population (6.0%), while R1441G was more common in Basque origin population (22.4%). Our conclusion is that both G2019S and R1441G mutations’ frequency varies markedly between Basque and non-Basque origin population reinforcing the importance of ethnicity consideration when establishing mutation prevalence.

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Title: LRRK2 G2019S and R1441G mutations associated with Parkinson’s disease are common in the Basque Country, but relative prevalence is determined by ethnicity
Authors: A. Gorostidi
J. Ruiz-Martínez
A. Lopez de Munain
A. Alzualde
J. F. Martí Massó
Publication date: 01-04-2009
Publisher: Springer-Verlag
Published in: Neurogenetics / Issue 2/2009
Print ISSN: 1364-6745
Electronic ISSN: 1364-6753
DOI: https://doi.org/10.1007/s10048-008-0162-0

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LRRK2 G2019S and R1441G mutations associated with Parkinson’s disease are common in the Basque Country, but relative prevalence is determined by ethnicity

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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