Top

Published in:

01-03-2012 | Minireview

Regeneration of extrahepatic bile ducts by tissue engineering with a bioabsorbable polymer

Authors: Mitsuo Miyazawa, Masayasu Aikawa, Katsuya Okada, Yasuko Toshimitsu, Kojun Okamoto, Isamu Koyama, Yoshito Ikada

Published in: Journal of Artificial Organs | Issue 1/2012

Abstract

With the widespread adoption of laparoscopic cholecystectomy and living-donor liver transplantation in recent years, complications involving the biliary system, stenosis in particular, are increasing. Various invasive and non-invasive techniques are now available for the treatment of biliary stenosis, but all are compromised by a high risk of recurrence and other problems. As a potential solution, our group has developed a bioabsorbable polymer (BAP) tube for implantation as a bypass graft. In the study reported here, we implanted this BAP tube and confirmed bile duct regeneration at the graft site after the tube had been degraded and absorbed into the body. We briefly describe our findings on extrahepatic biliary tissue regeneration, focusing on the possibility of its clinical application. This artificial bile duct may promote the development of novel treatments for biliary disease.

Ammori BJ, Joseph S, Attia M, Lodge JP. Biliary strictures complicating pancreaticoduodenectomy. Int J Pancreatol. 2000;28:15.PubMedCrossRef

Egawa H, Inomata Y, Uemoto S, Asonuma K, Kiuchi T, Fujita S, Hayashi M, Matamoros MA, Itou K, Tanaka K. Biliary anastomotic complications in 400 living related liver transplantations. World J Surg. 2001;25:1300.PubMedCrossRef

Wojcicki M, Milkiewicz P, Silva M. Biliary tract complications after liver transplantation: a review. Dig Surg. 2008;25:245–57.PubMedCrossRef

Maheshwari A, Maley W, Li Z, Thuluvath PJ. Biliary complications and outcomes of liver transplantation from donors after cardiac death. Liver Transpl. 2007;13:1645–53.PubMedCrossRef

Nishida S, Nakamura N, Kadono J, Komokata T, Sakata R, Madariaga JR, Tzakis AG. Intrahepatic biliary strictures after liver transplantation. J Hepatobiliary Pancreat Surg. 2006;13:511–6.PubMedCrossRef

Sugawara Y, Makuuchi M, Takayama T, Imamura H, Dowaki S, Mizuta K, Kawarasaki H, Hashizume K. Small-for-size grafts in living-related liver transplantation. J Am Coll Surg. 2001;192:510.PubMedCrossRef

Halme L, Hockerstedt K, Lautenschlager I. Cytomegalovirus infection and development of biliary complications after liver transplantation. Transplantation. 2003;75:1853.PubMedCrossRef

Miyazawa M, Torii T, Toshimitsu Y, Okada K, Koyama I, Ikada Y. A tissue-engineered artificial bile duct grown to resemble the native bile duct. Am J Transplant. 2005;5:1541–7.PubMedCrossRef

Shimono K, Nose Y. The need to develop artificial bile ducts. Artif Organs. 1995;19:115.PubMedCrossRef

10.

Xu J, Sun S, Zhang Q, Chen J, Wu L, Liu W, Guo G. Experiment for a polyurethane replacement of the common bile duct. Chin Med J (Engl). 1998;111:86.

11.

Rosen M, Ponsky J, Petras R, Fanning A, Brody F, Duperier F. Small intestinal submucosa as a bioscaffold for biliary tract regeneration. Surgery. 2002;132:480.PubMedCrossRef

12.

Teebken OE, Haverich A. Tissue engineering of small diameter vascular grafts. Eur J Vasc Endovasc Surg. 2002;23:475.PubMedCrossRef

13.

Shin’oka T, Imai Y, Ikada Y. Transplantation of a tissue-engineered pulmonary artery. N Engl J Med. 2001;344:532.PubMedCrossRef

14.

Kaihara S, Kim S, Benvenuto M, Kim BS, Mooney DJ, Tanaka K, Vacanti JP. End-to-end anastomosis between tissue-engineered intestine and native small bowel. Tissue Eng. 1999;5:339.PubMedCrossRef

15.

Perez A, Grikscheit TC, Blumberg RS, Ashley SW, Vacanti JP. Tissue-engineered small intestine: ontogeny of the immune system. Transplantation. 2002;74:619.PubMedCrossRef

16.

Ishizaki Y, Bandai Y, Shimomura K, Idezuki Y, Makuuchi M. Healing process of sutureless choledochojejunostomy in an experimental model. Br J Surg. 1995;82:1118–21.PubMedCrossRef

17.

Watanabe M, Shin’oka T, Tohyama S, Hibino N, Konuma T, Matsumura G, Kosaka Y, Ishida T, Imai Y, Yamakawa M, Ikada Y, Morita S. Tissue-engineered vascular autograft: inferior vena cava replacement in a dog model. Tissue Eng. 2001;7:429–39.PubMedCrossRef

18.

Noishiki Y, Tomizawa Y, Yamane Y, Matsumoto A. Autocrine angiogenic vascular prosthesis with bone marrow transplantation. Nat Med. 1996;2:90–3.PubMedCrossRef

19.

Bhattacharya V, McSweeney PA, Shi Q, Bruno B, Ishida A, Nash R, Storb RF, Sauvage LR, Hammond WP, Wu MH. Enhanced endothelialization and microvessel formation in polyester grafts seeded with CD34(+) bone marrow cells. Blood. 2000;95:581–5.PubMed

20.

Dalakas E, Newsome PN, Boyle S, Brown R, Pryde A, McCall S, Hayes PC, Bickmore WA, Harrison DJ, Plevris JN. Bone marrow stem cells contribute to alcohol liver fibrosis in humans. Stem Cells Dev. 2010;19:1417–25.PubMedCrossRef

21.

Jang YY, Collector MI, Baylin SB, Diehl AM, Sharkis SJ. Hematopoietic stem cells convert into liver cells within days without fusion. Nat Cell Biol. 2004;6:532–9.

22.

Oh SH, Witek RP, Bae SH, Zheng D, Jung Y, Piscaglia AC, Petersen BE. Bone marrow-derived hepatic oval cells differentiate into hepatocytes in 2-acetylaminofluorene/partial hepatectomy-induced liver regeneration. Gastroenterology. 2007;132:1077–87.PubMedCrossRef

23.

Tabibian JH, Asham EH, Han S, Saab S, Tong MJ, Goldstein L, Busuttil RW, Durazo FA. Endoscopic treatment of postorthotopic liver transplantation anastomotic biliary strictures with maximal stent therapy (with video). Gastrointest Endosc. 2010;71:505–12.PubMedCrossRef

24.

Pottakkat B, Vijayahari R, Prakash A, Singh RK, Behari A, Kumar A, Kapoor VK, Saxena R. Factors predicting failure following high bilio-enteric anastomosis for post-cholecystectomy benign biliary strictures. J Gastrointest Surg. 2010;14:1389–94.PubMedCrossRef

25.

Cantwell CP, Pena CS, Gervais DA, Hahn PF, Dawson SL, Mueller PR. Thirty years’ experience with balloon dilation of benign postoperative biliary strictures: long-term outcomes. Radiology. 2008;249:1050–7.PubMedCrossRef

26.

Sikora SS, Srikanth G, Agrawal V, Gupta RK, Kumar A, Saxena R, Kapoor VK. Liver histology in benign biliary stricture: fibrosis to cirrhosis… and reversal? J Gastroenterol Hepatol. 2008;23:1879–84.PubMedCrossRef

27.

Corvera CU, Blumgart LH, Darvishian F, Klimstra DS, DeMatteo R, Fong Y, D’Angelica M, Jarnagin WR. Clinical and pathologic features of proximal biliary strictures masquerading as hilar cholangiocarcinoma. J Am Coll Surg. 2005;201:862–9.PubMedCrossRef

28.

Lillemoe KD, Melton GB, Cameron JL, Pitt HA, Campbell KA, Talamini MA, Sauter PA, Coleman J, Yeo CJ. Postoperative bile duct strictures: management and outcome in the 1990 s. Ann Surg. 2000;232:430–41.PubMedCrossRef

29.

Shah SA, Grant DR, McGilvray ID, Greig PD, Selzner M, Lilly LB, Girgrah N, Levy GA, Cattral MS. Biliary strictures in 130 consecutive right lobe living donor liver transplant recipients: results of a Western center. Am J Transplant. 2007;7:161–7.PubMedCrossRef

30.

Judah JR, Draganov PV. Endoscopic therapy of benign biliary strictures. World J Gastroenterol. 2007;13:3531–9.PubMed

31.

Lillemoe KD, Pitt HA, Cameron JL. Current management of benign bile duct strictures. Adv Surg. 1992;25:119–74.PubMed

32.

Aikawa M, Miyazawa M, Okamoto K, Toshimitsu Y, Torii T, Okada K, Akimoto N, Ohtani Y, Koyama I, Yoshito I. A novel treatment for bile duct injury with a tissue-engineered bioabsorbable polymer patch. Surgery. 2010;147:575–80.PubMedCrossRef

33.

Tocchi A, Mazzoni G, Liotta G, Lepre L, Cassini D, Miccini M. Late development of bile duct cancer in patients who had biliary-enteric drainage for benign disease: a follow-up study of more than 1, 000 patients. Ann Surg. 2001;234:210–4.PubMedCrossRef

34.

Bettschart V, Clayton RA, Parks RW, Garden OJ, Bellamy CO. Cholangiocarcinoma arising after biliary-enteric drainage procedures for benign disease. Gut. 2002;51:128–9.PubMedCrossRef

35.

Herba MJ, Casola G, Bret PM, Lough J, Hampson LG. Cholangiocarcinoma as a late complication of choledochoenteric anastomoses. AJR Am J Roentgenol. 1986;147:513–5.PubMed

36.

Gouma DJ, Konsten J, Soeters PB, Von Meyenfeldt M, Obertop H. Long-term follow-up after choledochojejunostomy for bile duct stones with complex clearance of the bile duct. Br J Surg. 1989;76:451–3.PubMedCrossRef

37.

Maeda A, Yokoi S, Kunou T, Saeki S, Niinomi N, Uesaka K. Bile duct cancer developing 21 years after choledochoduodenostomy. Dig Surg. 2003;20:331–4.PubMedCrossRef

38.

Aikawa M, Miyazawa M, Okada K, Toshimitsu Y, Okamoto K, Akimoto N, Koyama I, Ikada Y. Development of a novel reflux-free bilioenteric anastomosis procedure by using a bioabsorbable polymer tube. J Hepatobiliary Pancreat Sci. 2010;17:284–90.PubMedCrossRef

39.

Sakai Y, Tsuyuguchi T, Ishihara T, Yukisawa S, Sugiyama H, Miyakawa K, Kuroda Y, Yamaguchi T, Ozawa S, Yokosuka O. Long-term prognosis of patients with endoscopically treated postoperative bile duct stricture and bile duct stricture due to chronic pancreatitis. J Gastroenterol Hepatol. 2009;24:1191–7.PubMedCrossRef

40.

Roumilhac D, Poyet G, Sergent G, Declerck N, Karoui M, Mathurin P, Ernst O, Paris JC, Gambiez L, Pruvot FR. Long-term results of percutaneous management for anastomotic biliary stricture after orthotopic liver transplantation. Liver Transpl. 2003;9:394–400.PubMedCrossRef

41.

Miyazawa M, Aikawa M, Okada K, Torii T, Otani Y, Koyama I. Development of bioabsorbable biliary tract stens for treatment of benign biliary stenosis. Jpn J Gastroenterol Surg. 2007;40:1548.

42.

Kasuya K, Shimazu M, Abe Y, Kikuchi S, Itoi T, Ikada Y, Aoki T, Tsuchida A. A newly developed degradable stent for pancreaticojejunostomy after pancreatoduodenectomy. Int Surg. 2010;95:247–56.PubMed

43.

Bandura WP, Arbulu A. Experimental replacement of the common bile duct with teflon graft. Am Surg. 1961;27:518–24.PubMed

44.

Gomez NA, Alvarez LR, Mite A, Andrade JP, Alvarez JR, Vargas PE, Tomala NE, Vivas AF, Zapatier JA. Repair of bile duct injuries with Gore-Tex vascular grafts: experimental study in dogs. J Gastrointest Surg. 2002;6:116–20.PubMedCrossRef

45.

Christensen M, Laursen HB, Rokkjaer M, Jensen PF, Yasuda Y, Mortensen FV. Reconstruction of the common bile duct by a vascular prosthetic graft: an experimental study in pigs. J Hepatobiliary Pancreat Surg. 2005;12:231–4.PubMedCrossRef

46.

Mendelowitz DS, Beal JM. Expanded polytetrafluoroethylene in reconstruction of the canine biliary system. Am J Surg. 1982;143:221–4.PubMedCrossRef

47.

Bottger T, Mann B, Pickel B, Weber W, Sorger K, Junginger T. Animal experiment studies of pedicled small intestine transplantation as partial extrahepatic bile duct replacement. Langenbecks Arch Chir. 1991;376:77–84.PubMedCrossRef

48.

Belzer FO, Watts JM, Ross HB, Dunphy JE. Auto-reconstruction of the common bile duct after venous patch graft. Ann Surg. 1965;162:346–55.PubMedCrossRef

49.

Aydin M, Bakir B, Kosem M, Kisli E, Genccelep M. Biliary tract reconstruction with autologous rectus sheath graft—an experimental study. Hepatogastroenterology. 2005;52:1019–22.PubMed

50.

Sedgwick CE. Reconstruction of the common bile duct with a free ureteral graft; an experimental study. Surg Gynecol Obstet. 1951;92:571–3.PubMed

51.

Gomez NA, Zapatier JA, Vargas PE. Re: “Small intestinal submucosa as a bioscaffold for biliary tract regeneration”. Surgery. 2004;135:460.PubMedCrossRef

52.

El-Assmy A, Hafez AT, El-Sherbiny MT, El-Hamid MA, Mohsen T, Nour EM, Bazeed M. Use of single layer small intestinal submucosa for long segment ureteral replacement: a pilot study. J Urol. 2004;171:1939–42.PubMedCrossRef

53.

Paradis K, Langford G, Long Z, Heneine W, Sandstrom P, Switzer WM, Chapman LE, Lockey C, Onions D, Otto E. Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue. The XEN 111 Study Group. Science. 1999;285:1236–41.PubMedCrossRef

54.

Fishman JA, Patience C. Xenotransplantation: infectious risk revisited. Am J Transplant. 2004;4:1383–90.PubMedCrossRef

Title: Regeneration of extrahepatic bile ducts by tissue engineering with a bioabsorbable polymer
Authors: Mitsuo Miyazawa
Masayasu Aikawa
Katsuya Okada
Yasuko Toshimitsu
Kojun Okamoto
Isamu Koyama
Yoshito Ikada
Publication date: 01-03-2012
Publisher: Springer Japan
Published in: Journal of Artificial Organs / Issue 1/2012
Print ISSN: 1434-7229
Electronic ISSN: 1619-0904
DOI: https://doi.org/10.1007/s10047-011-0590-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Regeneration of extrahepatic bile ducts by tissue engineering with a bioabsorbable polymer

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2012

Exchange of DuraHeart left ventricular assist device via a subcostal approach

Development trends of custom-made orthopedic implants

Interface of data transmission for a transcutaneous communication system using the human body as transmission medium

Successful treatment of cerebral hemorrhage using computed tomography angiography in a patient with left-ventricular-assist device

The effect of atmospheric pressure on ventricular assist device output

In memoriam: Dr. Yukihiko Nosé