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Pediatric and Developmental Pathology
Published in: Pediatric and Developmental Pathology 1/2005

01-02-2005

Epstein-Barr Virus–Associated Lymphoproliferative Disorder Presenting as Apparently Isolated Gastrointestinal Lesions in Childhood

Authors: N.J. Sebire, M. Malone, R.A. Risdon, A.D. Ramsay

Published in: Pediatric and Developmental Pathology | Issue 1/2005

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Abstract

We present an unusual case of post-transplant lymphoproliferative disorder (PTLD) presenting as apparently isolated gastrointestinal lesions in a pediatric renal transplant recipient. The multiple bowel lesions were related to Epstein-Barr virus and demonstrated the appearance of a monomorphic PTLD that was morphologically indistinguishable from diffuse large B-cell lymphoma. The patient responded to therapy with targeted anti-CD20 immunotherapy. PTLD may manifest as apparently isolated gastrointestinal tract lesions in childhood.
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Caillard, S, Lachat, V, Moulin, B 2000Posttransplant lymphoproliferative disorders in renal allograft recipients: report of 53 cases of a French multicenter studyPTLD French Working Group. Transpl Int138893
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Dharnidharka, VR Sullivan, EK Stablein, DM Tejani, AH Harmon, WE for the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS). 2001Risk factors for posttransplant lymphoproliferative disorder (PTLD) in pediatric kidney transplantation: a report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS)Transplantation7110651068
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Metadata
Title
Epstein-Barr Virus–Associated Lymphoproliferative Disorder Presenting as Apparently Isolated Gastrointestinal Lesions in Childhood
Authors
N.J. Sebire
M. Malone
R.A. Risdon
A.D. Ramsay
Publication date
01-02-2005
Publisher
Springer-Verlag
Published in
Pediatric and Developmental Pathology / Issue 1/2005
Print ISSN: 1093-5266
Electronic ISSN: 1615-5742
DOI
https://doi.org/10.1007/s10024-004-3031-3

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