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01-10-2014 | Original Article

Primary central nervous system Epstein–Barr virus-positive diffuse large B-cell lymphoma of the elderly: a clinicopathologic study of five cases

Authors: Siraj El Jamal, Shiyong Li, Renu Bajaj, Zixuan Wang, Lawrence Kenyon, Jon Glass, Changlee S. Pang, Sharathkumar Bhagavathi, Stephen C. Peiper, Jerald Z. Gong

Published in: Brain Tumor Pathology | Issue 4/2014

Abstract

We report five cases of primary central nervous system (CNS) Epstein–Barr virus (EBV)-positive lymphoma of the elderly. This represented an incidence of 4 % of primary CNS diffuse large B-cell lymphoma (DLBCL) after EBV screening in 134 cases. All five patients were 65 years or older with no previous history of congenital or iatrogenic immune deficiencies. The histologic morphology of all the cases was DLBCL, with variable amounts of necrosis. The cell of origin (COO) as determined by the Hans algorithm disclosed germinal center type in 2 cases and non-germinal center type in 3 cases. MYC translocation was not detected, and MYC overexpression was detected in only one case. Three patients died shortly after diagnosis, and the remaining 2 patients were in complete remission for 2 and 10 years, respectively. We conclude that EBV+ DLBCL among the elderly is uncommon in primary CNS lymphoma in the Eastern United States. The patients usually present with a single mass lesion with headache and sensorimotor symptoms. The histologic morphology is DLBCL, but clonal T-cell gene rearrangement may be detected. The outcome varies from case to case and appears to be unrelated to the COO or MYC status.

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Title: Primary central nervous system Epstein–Barr virus-positive diffuse large B-cell lymphoma of the elderly: a clinicopathologic study of five cases
Authors: Siraj El Jamal
Shiyong Li
Renu Bajaj
Zixuan Wang
Lawrence Kenyon
Jon Glass
Changlee S. Pang
Sharathkumar Bhagavathi
Stephen C. Peiper
Jerald Z. Gong
Publication date: 01-10-2014
Publisher: Springer Japan
Published in: Brain Tumor Pathology / Issue 4/2014
Print ISSN: 1433-7398
Electronic ISSN: 1861-387X
DOI: https://doi.org/10.1007/s10014-013-0173-x

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Primary central nervous system Epstein–Barr virus-positive diffuse large B-cell lymphoma of the elderly: a clinicopathologic study of five cases

Abstract

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Abstract

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