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11-04-2024 | Research

Relationship between tumor thickness and GATA3 immunoexpression in lip and tongue squamous cell carcinomas

Authors: Arthur Geovanni Borges Vital, Maria Carolina Magalhães de Carvalho, Caio Rodrigues Maia, Hébel Cavalcanti Galvão, Lélia Batista de Souza, Pedro Paulo de Andrade Santos

Published in: Oral and Maxillofacial Surgery

Abstract

Purpose

Lower lip squamous cell carcinomas (LLSCCs) exhibit lower levels of aggressiveness, low relations with metastases and better prognosis when compared with intraoral squamous cell carcinomas. Differently from the oral tongue squamous cell carcinomas (OTSCCs) have a high tendency towards local invasion and lymph nodal dissemination. Our aim was to evaluate tumor thickness in cases of oral squamous cell carcinoma and correlate it with histological grade of malignancy and GATA3 immunoreactivity.

Methods

Sixty specimens (30 LLSCCs and 30 OTSCCs) were scanned and digitized for the subsequent measurement of tumor thickness, histopathological examination, and quantitative analysis of GATA3 in the parenchyma and stroma of the tumors.

Results

Tumor thickness was lower in LLSCC compared to OTSCCs. Immunohistochemical analysis of GATA3 in parenchyma, stroma and both compartments showed higher immunoreactivity in LLSCCs compared to OTSCCs. We observed a negative correlation between tumor thickness and GATA3 expression in parenchyma, stroma, and both compartments. Our results revealed the presence of GATA3 in all cases both in the parenchyma and in the stroma. Higher expression was more related to LLSCCs, which are known to be less aggressive tumors than OTSCCs.

Conclusions

A greater tumor thickness was found in OTSCCs, which was correlated with lower expression of GATA3, suggesting that this protein is involved in the inhibition of proliferative, migratory, and invasive capacity.

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Title: Relationship between tumor thickness and GATA3 immunoexpression in lip and tongue squamous cell carcinomas
Authors: Arthur Geovanni Borges Vital
Maria Carolina Magalhães de Carvalho
Caio Rodrigues Maia
Hébel Cavalcanti Galvão
Lélia Batista de Souza
Pedro Paulo de Andrade Santos
Publication date: 11-04-2024
Publisher: Springer Berlin Heidelberg
Published in: Oral and Maxillofacial Surgery
Print ISSN: 1865-1550
Electronic ISSN: 1865-1569
DOI: https://doi.org/10.1007/s10006-024-01251-0

2024 ASCO Annual Meeting

Springer Medicine

Relationship between tumor thickness and GATA3 immunoexpression in lip and tongue squamous cell carcinomas

Abstract

Purpose

Methods

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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